Protein Alignment Klp61F and klp-12

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_001023349.1
• Gene: klp-12 / 178057
• WormBaseID: WBGene00002223
• Length: 1605
• Species: Caenorhabditis elegans
• Alignment Length: 1345
• Identity: 306/1345 - (22%)
• Similarity: 543/1345 - (40%)
• Gaps: 398/1345 - (29%)

  Fly    20 IQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLT----KKFTFDRSFGPESKQCDVY 80
            :||.:|:||..:||: :..:.|...|.|.        |.::|    :.||:|..|...:.|..||
 Worm     6 VQVALRIRPQGNREK-LEGSRVCTSVLPN--------DPQVTIGGDRSFTYDHVFDMPTLQYVVY 61

  Fly    81 SVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFDEL 145
            ...|..|::.:.:|||.||.||||||:||||||   .||...:..:.:.|:|:||||:.|.|.::
 Worm    62 ESCVEKLVDGLFDGYNATVLAYGQTGSGKTHTM---GTAFDAAVTQKEEDLGVIPRAIQHTFRKI 123

  Fly   146 R----------MMEVEYTMRISYLELYNEELCDLLSTDD--TTKIRIFDDSTKKGSVIIQGLEEI 198
            .          ::|..:.:.:.::||||:::.||||.|.  ::.|||.:||  :|.:::.|:|:.
 Worm   124 AECKAQAIEQGLLEPAFEVSVQFVELYNDDVLDLLSDDRSMSSSIRIHEDS--RGEIVLHGVEQR 186

  Fly   199 PVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRE-----NGIEGEDMLKIGKLN 258
            .|........:|:.|...|..|.|.||.||||||.:|::  |:::     |.::.....|.|:|.
 Worm   187 SVFDMHGTMDILKNGALNRTVAATNMNEQSSRSHAIFTL--HLKQQRVAANPLDESGEQKTGELE 249

  Fly   259 L---------VDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITAL---VDRAPHVPYRES 311
            :         |||||||.:.:.| ..|.|.:|.::||..||.||.||.||   ..:..|||||:|
 Worm   250 MEMLCAKFHFVDLAGSERMKRTG-ATGDRAKEGISINVGLLALGNVIAALGGANGKVSHVPYRDS 313

  Fly   312 KLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYT 376
            |||||||:||||.::|.:||..||...|..|||:|::||:|||.|:||...||..:.| ::.|..
 Worm   314 KLTRLLQDSLGGNSRTLMIACCSPSDSDFVETLNTMKYANRAKEIKNKVVANQDKSSK-MIGELR 377

  Fly   377 EEIDKLKRDLMAAR------DKNGIYLAEETYGEITLKLESQN------RELNEKMLLLKALKDE 429
            ..|..|:.:|:..:      |.:|..:..:.|.|........|      :.|||.:.:|:....:
 Worm   378 SRIAALEAELLEFKQGRRTVDVDGHEVVNDQYHENVYLTSEVNHLRFRVKALNETLDILRTENID 442

  Fly   430 LQNKEKIFS------------EVSMSLVEKT-----QELKKTEENLLNTKGTL------------ 465
            |:.|::..|            |..:..::.|     :||::|:..|..::.|.
 Worm   443 LKAKQEFNSIASLPTAGSGGAEGEVDAIQSTFRKYLEELERTKSLLYESQSTCDQLRKDNARWKA 507

  Fly   466 -------------LLTKKVLTKTKRRYKEKKELV--------------ASHMKTEQVLTTQAQEI 503
                         ..::|::...|:..:::::|:              :|..:.|...:.:|:|:
 Worm   508 LGASRGSGGGNAEFNSQKLIEMAKQEVEKQRKLMESVNIGGENVSSEYSSMAQDEDGTSNEAEEL 572

  Fly   504 LAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLS 568
            |...||..|:..    |.|.::|.:|         .:.:|.:|..:...|:        :||:|.
 Worm   573 LDEEDLDEDEDE----TAEEKQEQEE---------SEALQIDLSEVMIELD--------IKEKLI 616

  Fly   569 QEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQM 633
            .::..:...:|::.....|.:..|.|    .::|.....::::.|..|....:.|      |:.:
 Worm   617 DQLERAERQNQQIRETYEKKLRELME----RIKDTETERDRVLNEGGKRGGNNEQ------MKAI 671

  Fly   634 QQQQLLMSKEIQTNLQVIEENNQRH-KAMLDS---MQEKFATIIDSSLQSVEEHAKQMHKKLEQL 694
            :|:..|...:::..|:.||..::.| |.:..|   :|||  |.:.|.:..:::...::.||:.:
 Worm   672 KQEYELKITDLRKELKKIEALDKEHLKVIAKSQRELQEK--TRLKSEVVDLKKAKVELIKKMNE- 733

  Fly   695 GAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKN--------SISMSVHL 751
                    ::.:...::|||.||.|.:|    :...:|..:|:.|..|:        ..:..|:.
 Worm   734 --------DKKKQKTQQLANARAFATKE----KQTRLQANKIRTLEMKDKQREQFLKKTTQEVNA 786

  Fly   752 NKMEE------------------SRLTRN--HRIDDIKSGIQDYQKLGIEASQS----------- 785
            .:.|:                  :.:|.:  .|:..:..|:|..::|...|..|
 Worm   787 LRKEKAVAAATARQANRGTPRGGAAVTNSPARRVRGVVGGVQAIKELAFSAKASKVKWDVIVRKI 851

  Fly   786 ----AQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQE 846
                .:.::..:|||                        :.|:..||.      |...|||:..|
 Worm   852 EESARRRQIVQKMEA------------------------ELERYLNER------HAVMVEIVENE 886

  Fly   847 ---------------------SKQQLEAVQEKTEVNLEQMVDARQQLITED-------------- 876
                                 :||:|:.||::.....:.:.|..:.:...:
 Worm   887 KQFTQSQDVIYRDGLLEAIDSAKQKLQYVQDQITYQQKLICDVDEDITASNAENEPILDVGLKKQ 951

  Fly   877 --RQRFIGHATVAT---------DL----------VQESNRQFSEHAEHQRQQLQICEQELVRFQ 920
              :|.|.|..|::.         ||          |:...::.:...|...||..:.||.|....
 Worm   952 TIKQLFDGCDTLSEARYLLQHLFDLCIDKAALAAKVESEFKECAARIEQLEQQSSLKEQLLTSII 1016

  Fly   921 Q-----SELKTYAPTGTTPSKRDFVYPRTLVATSP---------HQEIVRRY---RQELDW---- 964
            :     .|::.:.|:....| |.......|.:.||         ....|||:   ::||.:
 Worm  1017 EDKNLVDEIEGFVPSDLRKS-RTSSQSSLLRSGSPSVVEDAHTLQNYKVRRHTATQEELLFANSE 1080

  Fly   965 -----SDLDTTATIDECSE-GEHDVSMHSVQELSETET------IMNSTPIEP-----------V 1006
                 ||.:...|:|..:: |:.|......:.::...|      ..|||...|           |
 Worm  1081 ENSMVSDANANPTVDVGADVGDSDERKEKKKRIAFVSTSPASTSFANSTSQSPSFSRNTRFRSTV 1145

  Fly  1007 DGV---------------------TVKRGCG---------------------------------- 1016
            .||                     |.::|..
 Worm  1146 GGVSNNNNIRKSVQPLINGKGVSSTARKGISRLPSVTEDPEIGIFAKSFPGRSRSNLMSSSSSTT 1210

  Fly  1017 TTRNSNSNALKPPVATGGKRSSSLSRSLTPSKTSPRGSPAFVRHN 1061
            ||..|:||.|.|...|....|.|:...::||..|...:...:|:|
 Worm  1211 TTTLSSSNLLNPRGTTSSSSSKSVFARISPSWLSDTCAELIMRNN 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	143/377 (38%)
		SMC_prok_B	<408..728	CDD:274008	67/385 (17%)
		SMC_prok_B	<651..>921	CDD:274008	62/372 (17%)
		Microtub_bind	923..>1004	CDD:464048	22/108 (20%)
klp-12	NP_001023349.1	KISc_KIF4	4..359	CDD:276823	139/369 (38%)
		CCDC158	<367..>791	CDD:464943	81/470 (17%)
		PRK03918	<602..>791	CDD:235175	41/221 (19%)
		Rcc_KIF21	857..931	CDD:410202	17/103 (17%)
		WD40	1277..1601	CDD:238121
		WD40 repeat	1288..1322	CDD:293791
		WD40 repeat	1327..1364	CDD:293791
		WD40 repeat	1373..1429	CDD:293791
		WD40 repeat	1439..1482	CDD:293791
		WD40 repeat	1489..1524	CDD:293791
		WD40 repeat	1531..1556	CDD:293791