Protein Alignment Klp61F and klp-18

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_501093.1
• Gene: klp-18 / 177474
• WormBaseID: WBGene00002228
• Length: 932
• Species: Caenorhabditis elegans
• Alignment Length: 964
• Identity: 255/964 - (26%)
• Similarity: 441/964 - (45%)
• Gaps: 208/964 - (21%)

  Fly    17 NQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYS 81
            :|.|:.|.||||   ..|....:|.:.|.|  .|||..|.:.  :|::.....|...|.|.||:.
 Worm     2 SQYIKCYGRVRP---SARLGAPSESLFVGG--RVVTIETDNG--SKRYELHHIFDSSSSQEDVFG 59

  Fly    82 VVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFDEL- 145
            .|...::|:.:.|||.|||||||||:||||||:|.     ..||.|...:|:|||::.|:|..|
 Worm    60 TVAKKIVEDCVEGYNGTVFAYGQTGSGKTHTMLGP-----CDSWTDQELMGLIPRSVEHVFQHLD 119

  Fly   146 ----RMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDV 206
                ...::.:::.:.::|||||.:.|||:..:..::|   ||.|  .:.:.|.....|.:..|:
 Worm   120 TKAKECQKLTFSVSVEFVELYNEVIYDLLNAKNKVQLR---DSGK--DIQLVGALSKNVDNPLDL 179

  Fly   207 YKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGK-LNLVDLAGSENVSK 270
            ..|::||.:.|.|.:|.|||:|||||.:  :::.|:.....||.:.:... ||||||||||..:.
 Worm   180 MHLVQKGWQERSTGSTAMNAESSRSHAL--LIIRIKTQERTGELVKERSSILNLVDLAGSERQTH 242

  Fly   271 AGNEKGIRVRETVNINQSLLTLGRVITALVDRAP---HVPYRESKLTRLLQESLGGRTKTSIIAT 332
            . ...|.|::|..|||.||..|||.|..|.|.:.   |||||:|.||.:|:.||||.:||::|..
 Worm   243 T-KSSGDRLKEATNINSSLTVLGRCIRLLADPSKAKGHVPYRDSHLTHILKNSLGGNSKTAVIVN 306

  Fly   333 ISPGHKDIEETLSTLEYAHRA---KNIQNKPEV---NQKLTKKTVLKEYTEEIDKLKRDLMAARD 391
            :.|.....:|:.|||.:|...   .||..:.||   :|:.:.|..::|..:|:|:.:..:   |.
 Worm   307 MHPDRDFAQESNSTLMFAQSCTMIMNIATRNEVMTGDQESSYKKAIQELRQEVDETREKV---RT 368

  Fly   392 KNGIYLAEETYGEITLKLES-----QNRELNEK--MLLLK----ALKDELQNK-EKIFSEVS--- 441
            :....|.|....::.||.|:     :|.:|..|  ..|||    :..:::.|: :||.||.|
 Worm   369 EFASQLDEAEVEQLRLKTENNSLRLENVDLRAKYDFALLKYTIGSENEQIVNEFKKIISEFSAAN 433

  Fly   442 -------MSLVEKT------------QELKKT--------EENLLNTKGTLLL------TKKVLT 473
                   ::|..:|            |||:|.        :|||   ..|:|:      .::..:
 Worm   434 SSSPFECIALKNQTLQLEIEASEKRYQELQKETSALRNRYQENL---DATILMQTPSAKERRSSS 495

  Fly   474 KTKRR----------------------------------------YKEK-KELVASHMKTEQVL- 496
            :.|||                                        .|:| :|..:..::||::|
 Worm   496 RPKRRETQYRPSPARMALFAEVETSEDAVLDLQCQNEKLSCELSSLKDKHEEATSKSIETERLLQ 560

  Fly   497 ---------------TTQAQEILA-------AADLATDDTHQLHGTIERRR--ELD----EKIRR 533
                           :.:..|.:|       .|:..|.|...||....|:|  ||:    |...|
 Worm   561 GEIVALQKEVSIVSESLRKSEAVAEGYKEKVTANNLTLDKLLLHIDASRKRIAELELSSKESENR 625

  Fly   534 SCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVS---QRLALNSSKSIEMLKEM 595
            |.::.:::....:.||........|:.|||:|:|:|:.::|:.:.   ..|.|:::    .:|::
 Worm   626 SSEELEEQRLYYVSMIEDLERKASDEYAALREELNQKTLSSNLLQVQVDELQLSNA----TIKKL 686

  Fly   596 CAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKA 660
            .| .|..:..|...|...:.|.|         :::.::::|.:|.|.|:.:..:.:|.:.
 Worm   687 NA-DLSTKAGLIRSLEDSIEKKS---------QMITRLEEQAVLDSSELSSTKRQLEHSR----- 736

  Fly   661 MLDSMQ-EKFATIIDSSLQS-VEEHAKQM----HKKLEQLGAMSLPDAEELQNLQEELANERALA 719
             |:::| .|.:....|::|: :::|.|.:    |||           ..|:|::|..|.|..|..
 Worm   737 -LEAIQWRKISEETTSAMQTQLKDHQKDIDQCRHKK-----------KLEIQSMQLSLDNANARV 789

  Fly   720 QQEDALLESMM--------MQMEQIKN-LRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDY 775
            ::.:|:::.:.        |:|.:|:| .:.|.|:|:....:.:....|..|....::.......
 Worm   790 KESEAMMKKLQNDEKQKFDMKMSEIENTFKEKLSVSLKKQEDTIRRQSLAENQGKLEVMENKNRV 854

  Fly   776 QKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNEN 829
            ....||:.||..::.|..:.||:......|.....|:|..|.|.:...:..:||
 Worm   855 LSETIESLQSQHSQDTEVINAGLRTRGDRVGYVDKLRVEKKALEETISQLRSEN 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	134/362 (37%)
		SMC_prok_B	<408..728	CDD:274008	89/446 (20%)
		SMC_prok_B	<651..>921	CDD:274008	41/194 (21%)
		Microtub_bind	923..>1004	CDD:464048
klp-18	NP_501093.1	KISc	5..328	CDD:276812	129/342 (38%)
		SMC_prok_B	<448..>716	CDD:274008	51/284 (18%)
		SMC_N	543..>917	CDD:481474	83/397 (21%)