Protein Alignment Klp61F and klp-6

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_498069.1
• Gene: klp-6 / 175683
• WormBaseID: WBGene00002218
• Length: 928
• Species: Caenorhabditis elegans
• Alignment Length: 1112
• Identity: 253/1112 - (22%)
• Similarity: 433/1112 - (38%)
• Gaps: 294/1112 - (26%)

  Fly    19 NIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLT--KKFTFDRSFG-----PESK- 75
            :|.|.|||||.|.||:......|:::......|.|   |.|..  |:||:|.|:.     .|.|
 Worm     6 SIIVAVRVRPFNDREKTRNCKLVIEMPDEETTVIR---DPKTNDEKRFTYDHSYWSHDGFSEKKN 67

  Fly    76 ------------QCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDD 128
                        |..|:..:...::.....||||::|||||||:||::::||.:
 Worm    68 GYLEPTDPHYADQRRVFEDLGRGVLANAWAGYNCSLFAYGQTGSGKSYSIVGFK----------- 121

  Fly   129 SDIGIIPRALSHLFDEL---RMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSV 190
            ::.||:|.....||.::   :...:::.:.:|.:|:|.|::.||||:....|..:......|...
 Worm   122 NNKGIVPIVCEELFKQIADNKKKNMQFEVFVSMMEIYCEKVRDLLSSTPPPKGGLKVREHPKNGF 186

  Fly   191 IIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIG 255
            .::.|..:||:|..::...:|:|.:.|..|.|.|||.|||:||:..|..:.:.:...|...:|..
 Worm   187 YVENLTTVPVNSFKEIEAKIEEGTKSRTIAATQMNATSSRAHTIVKITFNQKSSKQAGGTSMKKS 251

  Fly   256 KLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD-------RAPHVPYRESKL 313
            ::|||||||||..|.||.| |.|::|.:.|||||.||||||.||.|       :...:|||:|.|
 Worm   252 EINLVDLAGSERQSAAGTE-GDRLKEGIVINQSLTTLGRVIKALHDSQKAKSGKKTQIPYRDSVL 315

  Fly   314 TRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEE 378
            |.||:.:|||.:||.:||.|||...:.|||||||.:|.|||:|:....||:..|:: .|:|..||
 Worm   316 TCLLKNALGGNSKTIMIAAISPADINFEETLSTLRFADRAKSIKTNAVVNENQTER-ALRELREE 379

  Fly   379 IDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMS 443
            ..:|:..:...           |.|      ::.|.|:.:       |:.:|...:|     .|.
 Worm   380 NLRLQSQIQGG-----------TAG------DASNEEIEK-------LRRQLAENQK-----EME 415

  Fly   444 LVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAAD 508
            .:||:.:.|..||...:..|       ...|.:...|:||.....::..:..||......:...:
 Worm   416 EMEKSWQQKIAEEAAKHASG-------ASEKVEMEAKKKKMCHLWNLNEDPALTNVIVHFIPVGE 473

  Fly   509 ---------------------------LATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNL 546
                                       |..|..:|:| ......:||..|.......:.::|.|.
 Worm   474 SVVGNKPTSSGNFIQMSGLSILPQHVTLKNDGNNQIH-LSPCSEDLDIFINGKPVHGETQLQQND 537

  Fly   547 EMIGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLI 611
            .:..|..:||                         ..|:.....:..::..::.|
 Worm   538 RVFFGGNHLY-------------------------VFNNPTKKGIRTDITYENAQ---------- 567

  Fly   612 GEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSM--QEKFATIID 674
               .:|:..|:.|...:.:....::.|::.:|:.:.|.::    ||..||...:  ..||..::.
 Worm   568 ---AEIAQNHAAALGNRGLGGGSKRDLILEEELMSTLPLV----QRANAMATELGRNVKFEIVLV 625

  Fly   675 S---------------SLQSVEEHAKQMHKK---LEQLGAMSLPDAEELQNLQEELANERALAQQ 721
            |               .:.::.|....:.:|   :.:...|     :|:...:::.:.:..:.::
 Worm   626 SPEMRGLTSGLTEIWVKVHNISEDTYFLWEKSRFMNRYYGM-----QEMYEAKQDGSEDWNMPKE 685

  Fly   722 EDALLE---SMMMQMEQIKNLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEAS 783
            .|...|   |.:.....:..|:|      ..:|..:||
 Worm   686 RDPFYEPPDSPVFIASSVVFLQS------LAYLIDVEE--------------------------- 717

  Fly   784 QSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQESK 848
            |....:|:.| |.|:|.:  |::.||...   |.|..:|.::.::.:|                |
 Worm   718 QFPIVDLSGQ-EIGLLTV--GLSPCSTTG---KELRGEYVEDPDQLIG----------------K 760

  Fly   849 QQLEAVQEKTEVNLEQMVDARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICE 913
            .....|:..:.|.|     .|:.|.:..:.||.|...:.|......|.....|.|  ..|.:...
 Worm   761 NIAFKVKVISAVGL-----PRRILKSNCKYRFFGSKKMTTTATVSGNTPAYGHEE--TFQFKPVT 818

  Fly   914 QELVRF-QQSEL-----KTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYRQELDWSDLDTTAT 972
            :|:..: ..|.|     .|..|.|.:..|...                             :|..
 Worm   819 KEVADYLANSNLYITFWGTQRPRGASSRKNSI-----------------------------STIG 854

  Fly   973 IDECSEGEHDVS-----MHSVQELSETETI---MNSTPIEPVDG--------VTVKRGCGTTRNS 1021
            .:|..||.:...     :|.. :.||...|   ...|.::.||.        .::|:...||..|
 Worm   855 SNEAREGPNKAKRVERLVHQA-KTSENRNISVKALETVLKGVDDNENRKTRKQSMKKAGSTTIKS 918

  Fly  1022 NSNALKP 1028
            .|.:.||
 Worm   919 RSGSKKP 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	136/375 (36%)
		SMC_prok_B	<408..728	CDD:274008	51/369 (14%)
		SMC_prok_B	<651..>921	CDD:274008	47/293 (16%)
		Microtub_bind	923..>1004	CDD:464048	14/93 (15%)
klp-6	NP_498069.1	KISc_KIF1A_KIF1B	5..365	CDD:276816	134/373 (36%)
		tolA	<366..>446	CDD:236545	21/116 (18%)
		FHA_KIF28P	450..552	CDD:438761	15/127 (12%)
		KIF1B	659..699	CDD:463574	5/44 (11%)