Protein Alignment Klp61F and Kif11

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_001162583.1
• Gene: Kif11 / 171304
• RGDID: 621258
• Length: 1056
• Species: Rattus norvegicus
• Alignment Length: 1141
• Identity: 399/1141 - (34%)
• Similarity: 602/1141 - (52%)
• Gaps: 187/1141 - (16%)

  Fly     7 NTSRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHT--LDSKLTKK-FTFDR 68
            ::|.:.:::..:||||.||.||.|..||...:..||:....|:.|:..|  |..|.::| :|||.
  Rat     6 SSSSKKKEEKGKNIQVVVRCRPFNLAERKANAHSVVECDHARKEVSVRTAGLTDKTSRKTYTFDM 70

  Fly    69 SFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGI 133
            .||..:||.|||..||.|:::||:.|||||:|||||||||||.||.|..:.....:||:|...||
  Rat    71 VFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEVYTWEEDPLAGI 135

  Fly   134 IPRALSHLFDELRMMEVEYTMRISYLELYNEELCDLL--STDDTTKIRIFDDSTKKGSVIIQGLE 196
            |||.|..:|::|.....|:::::|.||:|||||.|||  |:|.:.::::|||...|..|||:|||
  Rat   136 IPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLSPSSDVSERLQMFDDPRNKRGVIIKGLE 200

  Fly   197 EIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVD 261
            ||.||:||:||::||||..:|.||.|||||.|||||:|||:.:|::|..|:||:::|||||||||
  Rat   201 EITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVD 265

  Fly   262 LAGSENVSKAGN-EKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQESLGGRT 325
            ||||||:.::|. :|  |.||..|||||||||||||||||:|.||:|||||||||:||:||||||
  Rat   266 LAGSENIGRSGAVDK--RAREAGNINQSLLTLGRVITALVERTPHIPYRESKLTRILQDSLGGRT 328

  Fly   326 KTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAAR 390
            :|||||||||...::||||||||||||||||.||||||||||||.::|||||||::|||||.|||
  Rat   329 RTSIIATISPASLNLEETLSTLEYAHRAKNIMNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAR 393

  Fly   391 DKNGIYLAEETY----GEITLKLESQNRELNEKMLLLKALKDELQ-------NKEKIFSEVSMSL 444
            :|||:|::||::    |::|:: |.|..||.||   :..|::||.       :.||..::....|
  Rat   394 EKNGVYISEESFRAMNGKVTVQ-EEQIAELAEK---IGVLEEELSKAAELFTDSEKELNQCKSDL 454

  Fly   445 VEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHM-KTEQVLTTQAQEILAAAD 508
            ..|||||:.|:::|..||..|:               |:|.|:|.: :||:.|...|.::|....
  Rat   455 QTKTQELETTQKHLQETKLQLV---------------KEEYVSSALERTEKKLHETASKLLNTVK 504

  Fly   509 LATDDTHQLHGTIERRRELD-------EKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQ 566
            ..|.|...||..::|:|.:|       |...||.....:.|::          |.:|.....|..
  Rat   505 ETTRDVSGLHSKLDRKRAIDAHNAEAQESFGRSLSSLFNNMEE----------LIRDGSEKQKAM 559

  Fly   567 LSQEMVNSSYVSQRLALN-SSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQ--HSQAFVAK 628
            |.        |.:.|..| .|.|:..|..:...:|:...::...::..|.:|||.  ..|:..|
  Rat   560 LD--------VHKALFGNLMSSSVSALDTISTTALESLMSIPENVLARVSQISDMILEEQSLAA- 615

  Fly   629 LMEQMQQQQLLMSK--EIQTNL-------------QVIEENNQ-RH--KAMLDSMQEK------- 668
                 |.:.:|...  |:.|||             .::..|.| :|  :|.: :|.||
  Rat   616 -----QSKTVLQGSIDELVTNLFTSLKTIIAPGVVSILNINRQLQHIFRASV-TMAEKVEDQKRE 674

  Fly   669 ---FATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEEL-QNLQEELANERALAQQEDALLESM 729
               |.:|:.::|..:.|:.           ..||.::::| .||.|:|...:....||...|.|.
  Rat   675 IDSFLSILCNNLHELRENT-----------VSSLVESQKLCGNLTEDLKTIKETHSQELCQLSSS 728

  Fly   730 MMQMEQIKNLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQM 794
            .  .|:...|..|.: ::...||.::|:   ...:..||.:....:.|..:..|.....||....
  Rat   729 W--AERFCALEKKYA-NIQKPLNSIQEN---TERKSTDIINKTTVHSKKILADSDGLLQELRHFN 787

  Fly   795 EAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNENVGSVR---VHHNQVEIIC-QESKQQLEAVQ 855
            |.|...::..|.:|..|..:::.::|    |..:..|::.   ||.:.....| .:.|::|:
  Rat   788 EEGTQLVEDSVGHCGSLSSNLETVSQ----EITQRCGTLNTSTVHFSDQWASCLSKRKEELQ--- 845

  Fly   856 EKTEVNLEQMV----DARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQEL 916
                 ||.:.|    :|....|||   :..||...    ::..:..|........::.:....||
  Rat   846 -----NLMEFVNGCCEASSSEITE---KIRGHRAA----IESQHSSFVVQITSDEEKFKAGSLEL 898

  Fly   917 VR-----------FQQSELKTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYRQELDWSDLDTT 970
            .:           |.|.:||...|||.||.:::::||.|||.|.|.::::.:.:::     ....
  Rat   899 DKTIKTGLTKLNCFLQQDLKLDIPTGMTPERKNYLYPSTLVRTEPREQLLDQLQKK-----QPKP 958

  Fly   971 ATIDECSEGEHDVS--MHSVQELSE--TETIMNSTPIEPVDGVTVKRGCGTT------------- 1018
            ..:..|||...:.|  |...:|:.|  ||.:::..|.     |.....|.::
  Rat   959 LMMLNCSESSKETSQDMEEDREVLEQSTEELVSQEPC-----VHTSADCSSSGGVPFFQHKKPHG 1018

  Fly  1019 RNSNSNALKPPVATGGKRSSSLSRSLTPSKTSPRGS 1054
            ::..:..|.|  ...||...:...|::.|:...|.|
  Rat  1019 KDKENRGLNP--VEKGKVEEASEHSISKSRLPLRAS 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	209/353 (59%)
		SMC_prok_B	<408..728	CDD:274008	86/366 (23%)
		SMC_prok_B	<651..>921	CDD:274008	60/302 (20%)
		Microtub_bind	923..>1004	CDD:464048	24/84 (29%)
Kif11	NP_001162583.1	KISc_BimC_Eg5	16..368	CDD:276815	209/353 (59%)
		PRK12704	350..>508	CDD:237177	76/176 (43%)
		YhaN	380..>785	CDD:443752	118/465 (25%)
		Microtub_bind	916..1052	CDD:464048	33/147 (22%)