DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and Kif11

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_001162583.1	Gene:	Kif11 / 171304	RGDID:	621258	Length:	1056	Species:	Rattus norvegicus

Alignment Length:	1141	Identity:	399/1141 - (34%)
Similarity:	602/1141 - (52%)	Gaps:	187/1141 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NTSRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHT--LDSKLTKK-FTFDR 68
            ::|.:.:::..:||||.||.||.|..||...:..||:....|:.|:..|  |..|.::| :|||.
  Rat     6 SSSSKKKEEKGKNIQVVVRCRPFNLAERKANAHSVVECDHARKEVSVRTAGLTDKTSRKTYTFDM 70

  Fly    69 SFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGI 133
            .||..:||.|||..||.|:::||:.|||||:|||||||||||.||.|..:.....:||:|...||
  Rat    71 VFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEVYTWEEDPLAGI 135

  Fly   134 IPRALSHLFDELRMMEVEYTMRISYLELYNEELCDLL--STDDTTKIRIFDDSTKKGSVIIQGLE 196
            |||.|..:|::|.....|:::::|.||:|||||.|||  |:|.:.::::|||...|..|||:|||
  Rat   136 IPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLSPSSDVSERLQMFDDPRNKRGVIIKGLE 200

  Fly   197 EIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVD 261
            ||.||:||:||::||||..:|.||.|||||.|||||:|||:.:|::|..|:||:::|||||||||
  Rat   201 EITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVD 265

  Fly   262 LAGSENVSKAGN-EKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQESLGGRT 325
            ||||||:.::|. :|  |.||..|||||||||||||||||:|.||:|||||||||:||:||||||
  Rat   266 LAGSENIGRSGAVDK--RAREAGNINQSLLTLGRVITALVERTPHIPYRESKLTRILQDSLGGRT 328

  Fly   326 KTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAAR 390
            :|||||||||...::||||||||||||||||.||||||||||||.::|||||||::|||||.|||
  Rat   329 RTSIIATISPASLNLEETLSTLEYAHRAKNIMNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAR 393

  Fly   391 DKNGIYLAEETY----GEITLKLESQNRELNEKMLLLKALKDELQ-------NKEKIFSEVSMSL 444
            :|||:|::||::    |::|:: |.|..||.||   :..|::||.       :.||..::....|
  Rat   394 EKNGVYISEESFRAMNGKVTVQ-EEQIAELAEK---IGVLEEELSKAAELFTDSEKELNQCKSDL 454

  Fly   445 VEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHM-KTEQVLTTQAQEILAAAD 508
            ..|||||:.|:::|..||..|:               |:|.|:|.: :||:.|...|.::|....
  Rat   455 QTKTQELETTQKHLQETKLQLV---------------KEEYVSSALERTEKKLHETASKLLNTVK 504

  Fly   509 LATDDTHQLHGTIERRRELD-------EKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQ 566
            ..|.|...||..::|:|.:|       |...||.....:.|::          |.:|.....|..
  Rat   505 ETTRDVSGLHSKLDRKRAIDAHNAEAQESFGRSLSSLFNNMEE----------LIRDGSEKQKAM 559

  Fly   567 LSQEMVNSSYVSQRLALN-SSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQ--HSQAFVAK 628
            |.        |.:.|..| .|.|:..|..:...:|:...::...::..|.:|||.  ..|:..|
  Rat   560 LD--------VHKALFGNLMSSSVSALDTISTTALESLMSIPENVLARVSQISDMILEEQSLAA- 615

  Fly   629 LMEQMQQQQLLMSK--EIQTNL-------------QVIEENNQ-RH--KAMLDSMQEK------- 668
                 |.:.:|...  |:.|||             .::..|.| :|  :|.: :|.||
  Rat   616 -----QSKTVLQGSIDELVTNLFTSLKTIIAPGVVSILNINRQLQHIFRASV-TMAEKVEDQKRE 674

  Fly   669 ---FATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEEL-QNLQEELANERALAQQEDALLESM 729
               |.:|:.::|..:.|:.           ..||.::::| .||.|:|...:....||...|.|.
  Rat   675 IDSFLSILCNNLHELRENT-----------VSSLVESQKLCGNLTEDLKTIKETHSQELCQLSSS 728

  Fly   730 MMQMEQIKNLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQM 794
            .  .|:...|..|.: ::...||.::|:   ...:..||.:....:.|..:..|.....||....
  Rat   729 W--AERFCALEKKYA-NIQKPLNSIQEN---TERKSTDIINKTTVHSKKILADSDGLLQELRHFN 787

  Fly   795 EAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNENVGSVR---VHHNQVEIIC-QESKQQLEAVQ 855
            |.|...::..|.:|..|..:::.::|    |..:..|::.   ||.:.....| .:.|::|:
  Rat   788 EEGTQLVEDSVGHCGSLSSNLETVSQ----EITQRCGTLNTSTVHFSDQWASCLSKRKEELQ--- 845

  Fly   856 EKTEVNLEQMV----DARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQEL 916
                 ||.:.|    :|....|||   :..||...    ::..:..|........::.:....||
  Rat   846 -----NLMEFVNGCCEASSSEITE---KIRGHRAA----IESQHSSFVVQITSDEEKFKAGSLEL 898

  Fly   917 VR-----------FQQSELKTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYRQELDWSDLDTT 970
            .:           |.|.:||...|||.||.:::::||.|||.|.|.::::.:.:::     ....
  Rat   899 DKTIKTGLTKLNCFLQQDLKLDIPTGMTPERKNYLYPSTLVRTEPREQLLDQLQKK-----QPKP 958

  Fly   971 ATIDECSEGEHDVS--MHSVQELSE--TETIMNSTPIEPVDGVTVKRGCGTT------------- 1018
            ..:..|||...:.|  |...:|:.|  ||.:::..|.     |.....|.::
  Rat   959 LMMLNCSESSKETSQDMEEDREVLEQSTEELVSQEPC-----VHTSADCSSSGGVPFFQHKKPHG 1018

  Fly  1019 RNSNSNALKPPVATGGKRSSSLSRSLTPSKTSPRGS 1054
            ::..:..|.|  ...||...:...|::.|:...|.|
  Rat  1019 KDKENRGLNP--VEKGKVEEASEHSISKSRLPLRAS 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	209/353 (59%)
		Kinesin	25..356	CDD:278646	196/336 (58%)
		Microtub_bind	923..>1009	CDD:290642	24/89 (27%)
Kif11	NP_001162583.1	KISc_BimC_Eg5	16..368	CDD:276815	209/353 (59%)
		KISc	18..366	CDD:214526	207/349 (59%)
		DUF4795	416..>486	CDD:292662	26/87 (30%)
		Microtub_bind	916..1052	CDD:290642	33/147 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352380
Domainoid	1	1.000	375	1.000	Domainoid score	I833
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3322
Inparanoid	1	1.050	535	1.000	Inparanoid score	I1155
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111985at33208
OrthoFinder	1	1.000	-	-		FOG0002556
OrthoInspector	1	1.000	-	-		oto98522
orthoMCL	1	0.900	-	-		OOG6_102884
Panther	1	1.100	-	-	LDO	PTHR47970
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1681
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900