Protein Alignment Klp61F and Kif5b

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_032474.2
• Gene: Kif5b / 16573
• MGIID: 1098268
• Length: 963
• Species: Mus musculus
• Alignment Length: 1109
• Identity: 264/1109 - (23%)
• Similarity: 473/1109 - (42%)
• Gaps: 243/1109 - (21%)

  Fly    19 NIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYSVV 83
            ||:|..|.||||..|.......|....|...|:.       .:|.:.|||.|...:.|..||:..
Mouse     8 NIKVMCRFRPLNESEVNRGDKYVAKFQGEDTVMI-------ASKPYAFDRVFQSSTSQEQVYNDC 65

  Fly    84 VSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFDELRMM 148
            ...::::||.|||.|:||||||.:||||||.|        ...|...:|||||.:..:|:.:..|
Mouse    66 AKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEG--------KLHDPEGMGIIPRIVQDIFNYIYSM 122

  Fly   149 E--VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKLLE 211
            :  :|:.:::||.|:|.:::.|||   |.:|..:.....|.....::|..|..|.|.|:|...::
Mouse   123 DENLEFHIKVSYFEIYLDKIRDLL---DVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTID 184

  Fly   212 KGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENVSKAGNEKG 276
            :||..|..|.|.||..|||||::|  ::::::...:.|..|. |||.||||||||.|||.|.| |
Mouse   185 EGKSNRHVAVTNMNEHSSRSHSIF--LINVKQENTQTEQKLS-GKLYLVDLAGSEKVSKTGAE-G 245

  Fly   277 IRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDIE 341
            ..:.|..|||:||..||.||:||.:.:.:||||:||:||:||:||||..:|:|:...||...:..
Mouse   246 AVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNES 310

  Fly   342 ETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLK----------------------- 383
            ||.|||.:..|||.|:|...||.:||.:...|:|.:|.:|.|
Mouse   311 ETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKTLRNTIQWLENELNRWRNGETVP 375

  Fly   384 ------------------RDLMAARDKNGIYL-------------AEETYGEITLKLESQNRELN 417
                              :|:....||....:             .||...::..:|:.::.|:|
Mouse   376 IDEQFDKEKANLEAFTADKDIAITSDKPAAAVGMAGSFTDAERRKCEEELAKLYKQLDDKDEEIN 440

  Fly   418 EKMLLLKALKDELQNKEKIFSEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEK 482
            ::..|::.||.::.::|::.:...........||.:.:.....:|..:....:.|.:....|.:|
Mouse   441 QQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQK 505

  Fly   483 KELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRREL-DEKIRRSCDQFKDRMQDNL 546
            .:.|....|..::|:.:..:  .:|.||:.|..     :::.:|: :.:.:|:.:.....::|..
Mouse   506 SQEVEDKTKEYELLSDELNQ--KSATLASIDAE-----LQKLKEMTNHQKKRAAEMMASLLKDLA 563

  Fly   547 EM---IGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKS-IEMLKEMCAQSLQDQTNLH 607
            |:   :|.:         .:|:.....|::..:...||.::..|| ::.:.:.|.|....||..:
Mouse   564 EIGIAVGNN---------DVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESN 619

  Fly   608 NKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATI 672
            .|:                               :|.:..|...:....:|:|.:.|:.|
Mouse   620 KKM-------------------------------EENEKELAACQLRISQHEAKIKSLTE----- 648

  Fly   673 IDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIK 737
               .||:||:..:|:.:.::.||              |||...||..:..:       |:.|.:.
Mouse   649 ---YLQNVEQKKRQLEESVDSLG--------------EELVQLRAQEKVHE-------MEKEHLN 689

  Fly   738 NLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLD 802
            .:::.|.:..:|. .:::..|.|...:|..::..::..:||..:.....|..:..|
Mouse   690 KVQTANEVKQAVE-QQIQSHRETHQKQISSLRDEVEAKEKLITDLQDQNQKMVLEQ--------- 744

  Fly   803 QGVANCSMLQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVD 867
                  ..|:|..:.| :..::|.:..:..:.|..::.|    :::|.|:.::|.....|:.:.:
Mouse   745 ------ERLRVEHERL-KATDQEKSRKLHELTVMQDRRE----QARQDLKGLEETVAKELQTLHN 798

  Fly   868 ARQQLITEDRQRFIGHATVATDLV--QESNRQFSEHAEHQRQQLQICEQELVRFQQSELKTYAPT 930
            .|:..:.:...|....|.|.:|..  ..:.:|.....|:..:||....::||| ..::|:...|.
Mouse   799 LRKLFVQDLATRVKKSAEVDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVR-DNADLRCELPK 862

  Fly   931 GTTPSKRDFVYPRTLVATSPHQEIV---------------RRYRQELDWSDLDTTATIDECSEGE 980
                      ..:.|.||:...:.:               :||:||           :|...|..
Mouse   863 ----------LEKRLRATAERVKALESALKEAKENASRDRKRYQQE-----------VDRIKEAV 906

  Fly   981 HDVSM----HSVQELSETETIMNSTPI--------EPVDGVTVKRGCGTTRNSNSNALKPPVATG 1033
            ...:|    ||.|         .:.||        .|....||:.|....:|:....|:   ..|
Mouse   907 RSKNMARRGHSAQ---------IAKPIRPGQHPAASPTHPGTVRGGGSFVQNNQPVGLR---GGG 959

  Fly  1034 GKRS 1037
            ||:|
Mouse   960 GKQS 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	138/347 (40%)
		SMC_prok_B	<408..728	CDD:274008	54/324 (17%)
		SMC_prok_B	<651..>921	CDD:274008	49/271 (18%)
		Microtub_bind	923..>1004	CDD:464048	17/107 (16%)
Kif5b	NP_032474.2	KISc_KHC_KIF5	6..325	CDD:276820	134/338 (40%)
		SMC_prok_B	<417..803	CDD:274008	78/482 (16%)
		Khc_CBD_cc	834..903	CDD:467880	16/90 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..963		15/66 (23%)
		Globular	915..963		14/59 (24%)