Protein Alignment Klp61F and Kif4

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_032472.2
• Gene: Kif4 / 16571
• MGIID: 108389
• Length: 1231
• Species: Mus musculus
• Alignment Length: 1147
• Identity: 310/1147 - (27%)
• Similarity: 523/1147 - (45%)
• Gaps: 230/1147 - (20%)

  Fly    20 IQVYVRVRPLNSRE------RCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCD 78
            ::|.:|.|||.|:|      .|:..     |.|..:||..:      .|.||:|..|.|.::|.:
Mouse    10 VRVALRCRPLVSKEIKEGCQTCLSF-----VPGEPQVVVGN------DKSFTYDFVFDPSTEQEE 63

  Fly    79 VYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFD 143
            |::..|:|||:.|..|||.||.||||||:|||::|.|..|||    .|.||.||:|||.:..||.
Mouse    64 VFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAE----QEHDSAIGVIPRVIQLLFK 124

  Fly   144 EL-RMMEVEYTMRISYLELYNEELCDLL--STDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDD 205
            |: :..:.|:|:::||||:||||:.|||  |.:..|:|.|.:| .|:|..|: ||.|..|....|
Mouse   125 EINKKSDFEFTLKVSYLEIYNEEILDLLCSSREKATQINIRED-PKEGIKIV-GLTEKTVLVASD 187

  Fly   206 VYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENVSK 270
            ....||:|...|..|:|.||:||||||.:|:|.:..|:...:.....  .||:||||||||...|
Mouse   188 TVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKNDKNSSFR--SKLHLVDLAGSERQKK 250

  Fly   271 AGNEKGIRVRETVNINQSLLTLGRVITALVD--RAPHVPYRESKLTRLLQESLGGRTKTSIIATI 333
            ...| |.|:||.:|||:.||.||.||:||.|  :...||||:||||||||:||||.:.|.:||.:
Mouse   251 TKAE-GDRLREGININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIACV 314

  Fly   334 SPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAARDKNGIYLA 398
            ||...::||||:||.||.||:.|:|||.:|        :.....|::.||:
Mouse   315 SPADSNLEETLNTLRYADRARKIKNKPIIN--------IDPQAAELNHLKQ-------------- 357

  Fly   399 EETYGEITLKLESQNRELNEKMLLLKALKDELQ---NKEKIFSEVSMSLVEKTQELKKTEENLLN 460
                         |.::|  ::|||:|....|.   |.|.  ||...||:||.|.|  .|||...
Mouse   358 -------------QVQQL--QILLLQAHGGTLPGDINVEP--SENLQSLMEKNQSL--VEENEKL 403

  Fly   461 TKG-------------TLLLTKKVLTKTKRRYKEKKELVASHMKTEQVL-TTQAQEI-------- 503
            ::|             .::||::...|...:.:|.:...|..:..:::: |.:.||:
Mouse   404 SRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRRHAACKVDLQKLVETLEDQELKENIEIIC 468

  Fly   504 ---LAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKE 565
               ...|.|:.:....:..||:...|.|.:::.|.|..:            |.:::..|.|..:.
Mouse   469 NLQQVIAQLSDEAAACMTATIDTAGEADTQVQSSPDTSR------------SSDVFSTQHALRQA 521

  Fly   566 QLSQEMVNSSYVSQRLALNSSKSIEMLK---EMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVA 627
            |:|:|::.   :::.|||..:.:.:|.:   ::.....|.|.|:.| |..||:.:..:..:..:.
Mouse   522 QMSKELIE---LNKALALKEALAKKMTQNDNQLQPIQFQYQDNIKN-LESEVLSLQREKEELVLE 582

  Fly   628 KLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDS---SLQSVEEHAKQMHK 689
            ....:....|..:|:..:..||.:|......|..|.. |.|...:.:|   ::..:.:..:.|..
Mouse   583 LQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLQE-QSKLLKLKESTEHTVSKLNQEIRMMKN 646

  Fly   690 KLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKM 754
            :..||......|||:.:..:::...|....::.|...:..::::|  :|.:.::::     |.:.
Mouse   647 QRVQLMRQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQYELLKLE--RNFQKQSNV-----LRRK 704

  Fly   755 EESRLTRNHRIDD-------IKSGIQDYQKLGIEASQSAQAE-LTSQMEAGMLCLDQGVANCSML 811
            .|.....|.|:.|       :....::.|..|:|::.:.... |.:::|. |:..::...:.:.|
Mouse   705 TEEAAAANKRLKDALQKQKEVAEKRKETQSRGMESTAARMKNWLGNEIEV-MVSTEEAKRHLNGL 768

  Fly   812 QVHMKNLNQ-----KYEKETNEN--VGSVRVHHNQVEIICQES------KQQLEAVQEKTEVNLE 863
            ....|.|.|     |.::|:.||  :...|...:..||..|:|      .:|:|:::.:.|:...
Mouse   769 LEERKILAQDVAQLKEKRESGENPPLKLRRRTFSYDEIHGQDSGAEDSIAKQIESLETELELRSA 833

  Fly   864 QMVDARQQLI---TEDR--QRFIGHATV----------ATDLVQ--------ESNRQFSEHAEHQ 905
            |:.|.:|:|:   :|||  ||:...||:          ..:||.        ||:...|:.:...
Mouse   834 QIADLQQKLLDAESEDRPKQRWESIATILEAKCAIKYLVGELVSSKILVSKLESSLNQSKASCID 898

  Fly   906 RQQLQICEQELVRFQQSELKTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYRQELDWSDLDTT 970
            .|::...||......::|||                ...:.....|||.|.....:|..|.:...
Mouse   899 VQKMLFEEQNHFAKIETELK----------------EELVKVEQQHQEKVLYLLSQLQQSQMTEK 947

  Fly   971 ATIDECSEGEHDV---------SMHSVQELSETETIMNSTPIEPVDGVTVKRGCGTTRNSNSNAL 1026
            ...:..||.|..:         .:..:||:.|    .|...::                 .::|:
Mouse   948 QLEESVSEKEQQLLSTLKCQEEELRKMQEVCE----QNQQLLQ-----------------ENSAI 991

  Fly  1027 KPPVA---TGGKRSSSLSRSLTPSKTS------PRGSPAFVR 1059
            |..:.   ...|:...|:|::..|..|      |:..|..::
Mouse   992 KQKLTLLQVASKQKPHLTRNIFQSPDSSFEYIPPKPKPCRIK 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	162/355 (46%)
		SMC_prok_B	<408..728	CDD:274008	72/353 (20%)
		SMC_prok_B	<651..>921	CDD:274008	62/316 (20%)
		Microtub_bind	923..>1004	CDD:464048	16/89 (18%)
Kif4	NP_032472.2	KISc_KIF4	8..338	CDD:276823	157/347 (45%)
		Smc	<518..>1005	CDD:440809	99/536 (18%)
		Globular	1001..1231		7/33 (21%)
		Pre-SET	<1082..1120	CDD:461530
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1189..1212