Protein Alignment Klp61F and Kif3b

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_032470.3
• Gene: Kif3b / 16569
• MGIID: 107688
• Length: 747
• Species: Mus musculus
• Alignment Length: 815
• Identity: 247/815 - (30%)
• Similarity: 399/815 - (48%)
• Gaps: 162/815 - (19%)

  Fly    15 KSNQNIQVYVRVRPLNSRERCIRSAEVVDV---VGPREVVTRHTLDSKLTKKFTFDRSFGPESKQ 76
            ||:::::|.||.||:|.:|:.....:||||   :|...|........::.|.||||..:...:||
Mouse     5 KSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTSHEMPKTFTFDAVYDWNAKQ 69

  Fly    77 CDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHL 141
            .::|.....||::.||.|:|.|:|||||||||||:||.|..        .|....|:||.:..|:
Mouse    70 FELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGVR--------GDPEKRGVIPNSFDHI 126

  Fly   142 FDEL-RMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFD--DSTKKGSVIIQGLEEIPVHSK 203
            |..: |....:|.:|.||||:|.||:.||||.|.|.::.:.:  |:    .|.::.|......|.
Mouse   127 FTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDT----GVYVKDLSSFVTKSV 187

  Fly   204 DDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENV 268
            .::..::..|.:.|....|.||..|||||.:|.|.:...|.|::||:.:::||||||||||||..
Mouse   188 KEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQ 252

  Fly   269 SKAGNEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESLGGRTKTSIIAT 332
            :|.| .:|.|::|...||.||..||.||:|||| ::.|:|||:||||||||:||||..||.::|.
Mouse   253 AKTG-AQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVAN 316

  Fly   333 ISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDL-------MAAR 390
            :.|...::||||:||.||:|||||:|||.||:. .|..:|:|:.|||.:||..|       ...|
Mouse   317 VGPASYNVEETLTTLRYANRAKNIKNKPRVNED-PKDALLREFQEEIARLKAQLEKRSIGRRKRR 380

  Fly   391 DK-------NGIYLAEETYGEITLKLESQN---------RELNEKMLLLKALKDELQNKEKIFSE 439
            :|       .|....||..||     |.:.         ||..||:        |:: |..|..:
Mouse   381 EKRREGGGSGGGGEEEEEEGE-----EGEEDGDDKDDYWREQQEKL--------EIE-KRAIVED 431

  Fly   440 VSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEIL 504
            .|:...||.:.||:.|:.:               :..||.|:..|::.:.:|..:      .::|
Mouse   432 HSLVAEEKMRLLKEKEKKM---------------EDLRREKDAAEMLGAKIKAME------SKLL 475

  Fly   505 AAADLATDDTHQLHGTIE-RRRELDEKIRRSCD---QFKDRMQDNLEMIGGSLNLYQDQQAALKE 565
            .......|.|::....:| :|:|:.|:.||..:   |.:.|.::.||               |||
Mouse   476 VGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLE---------------LKE 525

  Fly   566 QLSQEMVNSSYVS--QRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAK 628
                     :|.|  |.:.:.:.|    ||::.::....:..:|:        :.::|     .|
Mouse   526 ---------TYTSLQQEVDIKTKK----LKKLFSKLQAVKAEIHD--------LQEEH-----IK 564

  Fly   629 LMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMH--KKL 691
            ..::::|.|..:::|::....:||.        ...::||...:..|.....|:|.| :|  .:|
Mouse   565 ERQELEQTQNELTRELKLKHLIIEN--------FIPLEEKNKIMNRSFFDDEEDHWK-LHPITRL 620

  Fly   692 EQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKMEE 756
            |....|..|        ...:..:|.|:|....   |||::.|  ...|::|.:.:.:.:    .
Mouse   621 ENQQMMKRP--------VSAVGYKRPLSQHARM---SMMIRPE--PRYRAENIMLLELDM----P 668

  Fly   757 SRLTRNHRIDDIK--------SGIQDYQKLGIEAS 783
            ||.||::....|.        :.:||..::.::||
Mouse   669 SRTTRDYEGPAISPKVQAALDAALQDEDEIQVDAS 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	151/354 (43%)
		SMC_prok_B	<408..728	CDD:274008	63/336 (19%)
		SMC_prok_B	<651..>921	CDD:274008	31/143 (22%)
		Microtub_bind	923..>1004	CDD:464048
Kif3b	NP_032470.3	KISc_KIF3	8..340	CDD:276822	144/344 (42%)
		Smc	<355..>581	CDD:440809	62/301 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	374..412		8/42 (19%)
		Globular	580..747		31/150 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	698..747		2/6 (33%)