Protein Alignment Klp61F and Kif3a

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Alignment Length: 763
• Identity: 244/763 - (31%)
• Similarity: 392/763 - (51%)
• Gaps: 91/763 - (11%)

  Fly     7 NTSRQPQKKSNQNIQVYVRVRPLNSRER--CIRSAEVVDVVGPREVVTRHTLDS--KLTKKFTFD 67
            |.|.:|:  |..|::|.||.||||.||:  |.|.|..||.:  |..:|.|..||  :..|.||||
Mouse     4 NKSEKPE--SCDNVKVVVRCRPLNEREKSMCYRQAVSVDEM--RGTITVHKTDSSNEPPKTFTFD 64

  Fly    68 RSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVG-NETAELKSSWEDDSDI 131
            ..|||||||.|||::...|:|:.||.|||.|:|||||||||||.||.| .....|:
Mouse    65 TVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLR--------- 120

  Fly   132 GIIPRALSHLFDELRMME--VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQG 194
            |:||.:.:|:|..:...|  ..:.:|:||||:||||:.|||..|.|.::.:  .......|.|:.
Mouse   121 GVIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEV--KERPDVGVYIKD 183

  Fly   195 LEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNL 259
            |....|::.||:.:::..|.:.|....|.||..|||||.:|:|.:...|.|::|...:::|||:|
Mouse   184 LSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHL 248

  Fly   260 VDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESLGG 323
            |||||||..:|.| ..|.|::|...||.||.|||.||:|||| ::.|||||.||||||||:||||
Mouse   249 VDLAGSERQAKTG-ATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGG 312

  Fly   324 RTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMA 388
            .:||.:.|.|.|...:.:||:|||.||:|||||:||..:|:. .|..:|:::.:||::||:.|..
Mouse   313 NSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINED-PKDALLRQFQKEIEELKKKLEE 376

  Fly   389 ARDKNGIYLA----EETYGEITLKLESQNRELNEK---------MLLLKALKDELQN---KEKIF 437
            ..:.:|..::    ::..||:....|.:.:.....         .::.|.|.:.|.:   |:|:.
Mouse   377 GEEVSGSDISGSEEDDEEGELGEDGEKKKKRRGSSSSSSSDSTCSVIEKPLDEFLPHQAGKKKVS 441

  Fly   438 SEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMK-TEQVLTTQAQ 501
            .:..:.:..|..|.:|..|..|:.:..  ...|...:.:||.|:..:....|.. .|::...:.:
Mouse   442 PDKMVEMQAKIDEERKALETKLDMEEE--ERNKARAELERREKDLLKAQQEHQSLLEKLSALEKK 504

  Fly   502 EILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQ 566
            .|:...||......|.....|...||:|: ||..:|.:..:::                   |||
Mouse   505 VIVGGVDLLAKAEEQEKLLEESNMELEER-RRRAEQLRKELEE-------------------KEQ 549

  Fly   567 LSQEMVNSSYVS-QRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLM 630
            ...: :...|.| |..|...:|.::.:..|...:..:..:|            .|..|..:..|:
Mouse   550 ERLD-IEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADL------------QQEHQREIEGLL 601

  Fly   631 EQMQQQQLLMSKEIQTNLQVIEE-NNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQL 694
            |.::|    :|:|::..:.:|:. ..|.::.|:::.......|.:..|:.|......|.|:
Mouse   602 ENIRQ----LSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQ---- 658

  Fly   695 GAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSK 742
              ..:||.:|....:.:|::. .||..|::|.:| :|::|:.:..:.|
Mouse   659 --TPVPDKKERDPFEVDLSHV-YLAYTEESLRQS-LMKLERPRTSKGK 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	165/355 (46%)
		SMC_prok_B	<408..728	CDD:274008	61/334 (18%)
		SMC_prok_B	<651..>921	CDD:274008	20/93 (22%)
		Microtub_bind	923..>1004	CDD:464048
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	160/345 (46%)
		Smc	<450..>614	CDD:440809	39/202 (19%)