Protein Alignment Klp61F and Kif17

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_034753.1
• Gene: Kif17 / 16559
• MGIID: 1098229
• Length: 1038
• Species: Mus musculus
• Alignment Length: 1147
• Identity: 319/1147 - (27%)
• Similarity: 502/1147 - (43%)
• Gaps: 248/1147 - (21%)

  Fly    16 SNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPRE--VVTRHTLDSKLTKKFTFDRSFGPESKQCD 78
            ::::::|.||.||:|.|||.:....||.|...|.  .:.......:..|:||||.::..|.....
Mouse     2 ASESVKVVVRCRPMNKRERELSCQSVVTVDSARGQCFIQNPGAADEPPKQFTFDGAYYIEHFTEQ 66

  Fly    79 VYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFD 143
            :|:.:..||:|.|..|||.|:|||||||:||:.||.|..        :.....||||||..|:|:
Mouse    67 IYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLP--------DPPCQRGIIPRAFEHVFE 123

  Fly   144 ELRMME-VEYTMRISYLELYNEELCDLLSTDDTTKIRI-FDDSTKKGSVIIQGLEEIPVHSKDDV 206
            .::..| .::.:|.||||:|||::.|||..|  ||.|: ..:..:|| |.::||....||:....
Mouse   124 SVQCAENTKFLVRASYLEIYNEDVHDLLGAD--TKQRLELKEHPEKG-VYVKGLSMHTVHNVAQC 185

  Fly   207 YKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENVSKA 271
            .:::|.|.:.|....||||..|||||::|:|.:.|......|:|.|:.||||||||||||..||.
Mouse   186 ERVMETGWKNRAVGYTLMNKDSSRSHSIFTINIEIYAVDERGKDHLRAGKLNLVDLAGSERQSKT 250

  Fly   272 GNEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESLGGRTKTSIIATISP 335
            | ..|.|::|...||.||..||.||:|||| |..|:|||:||||||||:||||.|||.::|.:||
Mouse   251 G-ATGERLKEATKINLSLSALGNVISALVDGRCKHIPYRDSKLTRLLQDSLGGNTKTLMVACLSP 314

  Fly   336 GHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLK------------RDLMA 388
            ...:.:||||||.||:|||||:|||.:|:. .|..:|:||.|||.:||            ..|::
Mouse   315 ADNNYDETLSTLRYANRAKNIKNKPRINED-PKDALLREYQEEIKRLKAILAQQMGPGNLSALLS 378

  Fly   389 ARDKNGIYLAEE-----TYGEITLKLESQ--NRELNEKMLLLKA-LKDELQNKEKIFSEVSMSLV 445
            .:...|...:||     |..:...:.|.|  ..|..|::..||| .:.|.:::.::..:::....
Mouse   379 TQTPPGPVQSEEKLLSPTTVQQDTEAEKQLIREEYEERLARLKADYEAEQESRVRLQEDITAMRN 443

  Fly   446 EKTQELKKTEENLLNTKGT-LLLTKKVLTKTKRRYKEKKELVA--SHMKTEQVLTTQAQEILAAA 507
            ....:|...:|||...|.| .:|..:||.||:  ...:.||.:  .:....|..|.....||:..
Mouse   444 SYDVKLSTLQENLRKEKETEAILKAEVLCKTE--VMSRAELASGPEYSPPLQYETAVKPTILSMP 506

  Fly   508 D-------------LATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGS---LNLY 556
            |             ||.::.|......|...|.:|     |...:|....  |...|.   .|:.
Mouse   507 DMPPSGKVTKSQAPLAFEEPHGETSRSEFSFESNE-----CSTLEDSATS--EAFPGPEEFSNME 564

  Fly   557 QDQQAALKEQL--------SQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQ-TNLHNKL-- 610
            ....|||.|..        .||...|...::|....:..|:|.|:.:.  ||||. ..:..||
Mouse   565 FSMAAALTESRYLPEEYLGGQEAAASPLEAERYVQENEPSLEPLRILA--SLQDPFAEVEAKLAR 627

  Fly   611 IGEVMKISDQHSQAFVAKLMEQMQQQQLL------------------MSKEIQTNLQVIEENNQR 657
            :...:.:||. ||..|.::.:|.....||                  :..|...||:|.||  ..
Mouse   628 LSSTVAMSDS-SQTVVPQIPKQPSSADLLEPSDTKSEADVAVADNVVLGTEPDVNLRVAEE--VV 689

  Fly   658 HKAMLDSMQEKFATIIDSSLQSVEEHAK------QMHKKLEQLGA-MSLPDAEELQNLQEELANE 715
            .:|......|..|.:  :.:..|.|.|:      .:..:.|.:|. :::...||||.:.:    :
Mouse   690 SEAETGVWMESEAQV--AHVAQVSEEAQPQPLLAMVSVRRESVGVEVAVLTEEELQPVDQ----Q 748

  Fly   716 RALAQQEDALLESMMMQMEQIKN--LRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKL 778
            :.||:.:  |||..::..||.||  ||.|:           :..:...:.|...:.:.:|:..:.
Mouse   749 QVLARLQ--LLEQQVVGGEQAKNKDLREKH-----------KRRKRYADERKKQLVAALQNSDED 800

  Fly   779 G-----IEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNENVGSVRVHHN 838
            |     :....|.|.|:.::.:    .|::........:|.:|:|..:::.|..:.:.::|
Mouse   801 GGDWVLLNVYDSIQEEVRAKSK----LLEKMQRKLRAAEVEIKDLQSEFQLEKIDYLATIR---- 857

  Fly   839 QVEIICQESKQQLEAVQEKTEVNLEQMVDARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAE 903
                           .||:..:..:|:::..|.||
Mouse   858 ---------------RQERDSMLFQQLLEQVQPLI------------------------------ 877

  Fly   904 HQRQQLQICEQELVRFQQS--------------ELKT---YAPTGT--TPSKRDFVYPRTLVATS 949
              |:.......|.:|.:.|              .|||   ..||||  .|:::    ...:.:..
Mouse   878 --RRDCNYSNLEKIRRESSWDEDNGFWKIPDPIILKTSLPVVPTGTQNKPARK----TSAVDSGE 936

  Fly   950 PHQEIVRRYRQELDWSDLDTTATIDECSEGEHDVSMHSVQELS----ETETIMNSTPIEPVDGVT 1010
            ||.:...||:..|..||.:..|:       .:..|..:.|.||    ::.|..||.|
Mouse   937 PHMQEEDRYKLMLSRSDSENIAS-------NYFRSKRASQILSTDPMKSLTYHNSPP-------- 986

  Fly  1011 VKRGCGTTRNSNSNALKPPVATGGKRSSSLSRSLTPSKTSPR 1052
                 |...:.::|:..||             :.||....||
Mouse   987 -----GLNSSLSNNSALPP-------------TQTPEMPQPR 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	159/352 (45%)
		SMC_prok_B	<408..728	CDD:274008	84/377 (22%)
		SMC_prok_B	<651..>921	CDD:274008	47/283 (17%)
		Microtub_bind	923..>1004	CDD:464048	24/89 (27%)
Kif17	NP_034753.1	Motor_domain	4..335	CDD:473979	153/342 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..401		4/21 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	503..559		12/62 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	636..657		7/21 (33%)
		COG4913	655..>874	CDD:443941	46/262 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	916..940		7/27 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	976..1038		12/61 (20%)