Protein Alignment Klp61F and Kif13a

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_036013758.1
• Gene: Kif13a / 16553
• MGIID: 1098264
• Length: 1840
• Species: Mus musculus
• Alignment Length: 1190
• Identity: 294/1190 - (24%)
• Similarity: 507/1190 - (42%)
• Gaps: 271/1190 - (22%)

  Fly    16 SNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVV------TRHTLDSKLTKKFTFDRSFG--P 72
            |:..::|.|||||:|.||..:.:..||::.|.:.|:      |:.. :.|..|.|.||..|.  .
Mouse     2 SDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQG-ERKPPKVFAFDYCFWSMD 65

  Fly    73 ESK------QCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDI 131
            ||.      |..|:..:...::|:...|||..:|||||||:||:.:|:|:  ||         .:
Mouse    66 ESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGH--AE---------QL 119

  Fly   132 GIIPRALSHLFDELRMMEVE---YTMRISYLELYNEELCDLL---STDDTTKIRIFDDSTKKGSV 190
            |:|||....||..:.:.:.|   :.:.:||:|:|||::.|||   .:..:.|:|    ..|....
Mouse   120 GLIPRLCCALFQRIALEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVR----EHKVLGP 180

  Fly   191 IIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVV----HIRENGIEGEDM 251
            .:.||.::.|.|.:|:..|:.:|.:.|..|.|.||.:|||||.||:|::    :..::|..||
Mouse   181 YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGE-- 243

  Fly   252 LKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRA------PHVPYRE 310
             |:.|::||||||||.|||.| ..|.|::|..|||:||.|||.||::|.|:|      ..||||:
Mouse   244 -KVSKVSLVDLAGSERVSKTG-AAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKNKFVPYRD 306

  Fly   311 SKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEY 375
            |.||.||:::|||.::||:||||||...:.|||||||.||.|||.|.|...||:....| |::|.
Mouse   307 SVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAK-VIREL 370

  Fly   376 TEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKA--LKDELQNKEKIFS 438
            .||::||:..|..|.                               .:||  ||::|:..||:..
Mouse   371 REEVEKLREQLSQAE-------------------------------AMKAPELKEKLEESEKLIK 404

  Fly   439 EVSMSLVEKTQELKKTE------ENLLNTKGTLLLTKKVLTKTKRRY-------KEKKELVASHM 490
            |::::..||   |:|||      :..|.:.|..|.|..:.....:.|       ....||:..::
Mouse   405 ELTVTWEEK---LRKTEAIAQERQRQLESMGISLETSGIKVGDDKCYLVNLNADPALNELLVYYL 466

  Fly   491 KTE-QVLTTQAQEIL----------AAADLATD---------------------DTHQL-HGTIE 522
            |.. :|....:|:|.          ...|:|.|                     .|.|| ||  :
Mouse   467 KDHTRVGADTSQDIQLFGIGIQPEHCEIDIAADGDITLTPKENARSCVNGTLVCSTTQLWHG--D 529

  Fly   523 R---------RRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVS 578
            |         |..|.::.||  |..||..:   |......:|....:|:.:...:.|......:.
Mouse   530 RILWGNNHFFRINLPKRKRR--DWLKDFER---ETSSAEHDLDAASEASSEPDYNYEFAQMEVIM 589

  Fly   579 QRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQH---------SQAFVAKLMEQ-- 632
            :.|..|....|..|....:........:...|:....|:..||         .|....:.:|:
Mouse   590 KTLNSNGGFPIVSLSAWWSSPWWSYLKILFPLLWFQTKLVHQHWERDPVQNVVQVLEKQYLEEKR 654

  Fly   633 --MQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLG 695
              :::|:|:..:|::...|.:....|..    .|..::.|....::.|.|.:.|::..:...|
Mouse   655 TALEEQRLMYERELEQLRQQLSPERQPP----SSASDRLAYSSQTAQQKVTQWAEERDELFRQ-- 713

  Fly   696 AMSLPDAEELQNLQEELANERALAQQEDALLESMMMQME-----QI--KNL---RSKNSISMSVH 750
                    .|..|:|:|.....|.::.:.|.|.|....:     ||  .||   |.:.:|.....
Mouse   714 --------SLAKLREQLVKANTLVREANFLAEEMSKLTDYQVTLQIPAANLSANRKRGAIVSEPA 770

  Fly   751 LNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSA-QAE----------LTSQMEAGMLCLDQG 804
            :....:.:.|:...|:.:::.:.|.:.|..|..::. :|:          ..:|....::    |
Mouse   771 IQARRKGKGTQVWTIEKLENKLIDMRDLYQEWKENVPEAKRLYGKRGDPFYEAQENHNLI----G 831

  Fly   805 VAN-------CSM-LQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVN 861
            |||       |.: ||..:..::|:     .|..|.:.|...::.....|...:.::.:..:|..
Mouse   832 VANVFLECLFCDVKLQYAVPIISQQ-----GEVAGRLHVEVTRITGTIPERMAEDDSSENSSESG 891

  Fly   862 LEQMVDARQQLITEDRQ------------------RFI---------GHATVATDLV-------Q 892
            ..::||:..::|...::                  .|:         ..:|||..:|       |
Mouse   892 SLEVVDSSGEVIHRVKKLTCRVIIKEATGLPISLSNFVFCQYTFWDQCESTVAAPVVDPDVPSPQ 956

  Fly   893 ESNRQFSEHAEHQRQQLQICEQELVRFQQS---ELKTY----APTGTTPSKRDFVYPRTLVATSP 950
            ..:.|::....|.:..:....:|.:.|...   .::.:    |..|:...:.|.::.:|......
Mouse   957 SKDAQYTVTFSHCKDYVVTVTEEFLEFISDGALAIEVWGHRCAGNGSPIWEVDSLHAKTRTLHDR 1021

  Fly   951 HQEIVRR---YRQELDWSDLDTTATIDECSEGEHDVSMHSVQELSETETIMNSTPIEPVDG---- 1008
            ..|:.||   :...|:.::|...|.: |..:.: ||:...|.:|.:..:......::||..
Mouse  1022 WNEVTRRIEVWISILELNELGDYAAV-ELHQAK-DVNTGGVFQLRQGHSRRVQVTVKPVQHSGTL 1084

  Fly  1009 -------VTVKRGCGTTRNS 1021
                   ::|..||.|.|::
Mouse  1085 PLMVEAILSVSIGCVTARST 1104

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	149/377 (40%)
		SMC_prok_B	<408..728	CDD:274008	72/389 (19%)
		SMC_prok_B	<651..>921	CDD:274008	54/332 (16%)
		Microtub_bind	923..>1004	CDD:464048	15/87 (17%)
Kif13a	XP_036013758.1	KISc_KIF1A_KIF1B	5..359	CDD:276816	147/373 (39%)
		Kinesin_assoc	356..468	CDD:465047	32/146 (22%)
		FHA_KIF13A	446..554	CDD:438781	21/111 (19%)
		SMC_prok_B	<646..>801	CDD:274008	30/168 (18%)
		KIF1B	788..832	CDD:463574	5/47 (11%)
		DUF3694	<1255..1319	CDD:463599