Protein Alignment Klp61F and Kif11

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_034745.1
• Gene: Kif11 / 16551
• MGIID: 1098231
• Length: 1052
• Species: Mus musculus
• Alignment Length: 1115
• Identity: 384/1115 - (34%)
• Similarity: 605/1115 - (54%)
• Gaps: 143/1115 - (12%)

  Fly     8 TSRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHT--LDSKLTKK-FTFDRS 69
            :|.:.:::..:||||.||.||.|..||...:..||:....|:.|:..|  |..|.:|| :|||..
Mouse     6 SSLKKKEEKGRNIQVVVRCRPFNLAERKANAHSVVECDHARKEVSVRTAGLTDKTSKKTYTFDMV 70

  Fly    70 FGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGII 134
            ||..:||.|||..||.|:::||:.|||||:|||||||||||.||.|..:.....:||:|...|||
Mouse    71 FGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEVYTWEEDPLAGII 135

  Fly   135 PRALSHLFDELRMMEVEYTMRISYLELYNEELCDLL--STDDTTKIRIFDDSTKKGSVIIQGLEE 197
            ||.|..:|::|.....|:::::|.||:|||||.|||  |:|.:.::::|||...|..|||:||||
Mouse   136 PRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLSPSSDVSERLQMFDDPRNKRGVIIKGLEE 200

  Fly   198 IPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDL 262
            |.||:||:||::||||..:|.||.|||||.|||||:|||:.:|::|..|:||:::||||||||||
Mouse   201 ITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDL 265

  Fly   263 AGSENVSKAGN-EKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQESLGGRTK 326
            |||||:.::|. :|  |.||..|||||||||||||||||:|.||:|||||||||:||:||||||:
Mouse   266 AGSENIGRSGAVDK--RAREAGNINQSLLTLGRVITALVERTPHIPYRESKLTRILQDSLGGRTR 328

  Fly   327 TSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAARD 391
            |||||||||...::||||||||||||||||.||||||||||||.::|||||||::|||||.|||:
Mouse   329 TSIIATISPASFNLEETLSTLEYAHRAKNIMNKPEVNQKLTKKALIKEYTEEIERLKRDLAAARE 393

  Fly   392 KNGIYLAEETY----GEITLKLESQNRELNEKMLLLKALKDELQNKEKIF-------SEVSMSLV 445
            |||:|::||::    |::|:: |.|..||.||   :..|::||....::|       .:....|.
Mouse   394 KNGVYISEESFRAMNGKVTVQ-EEQIVELVEK---IAVLEEELSKATELFMDSKNELDQCKSDLQ 454

  Fly   446 EKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHM-KTEQVLTTQAQEILAAADL 509
            .|||||:.|:::|..||..|:               |:|.|:|.: :||:.|...|.::|.....
Mouse   455 TKTQELETTQKHLQETKLQLV---------------KEEYVSSALERTEKTLHDTASKLLNTVKE 504

  Fly   510 ATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQ---DNLEMIGGSLNLYQDQQAALKEQLSQEM 571
            .|.....||..::|:|.:||....:.:.|...:.   :|:|      .|.:|..|..|..|.
Mouse   505 TTRAVSGLHSKLDRKRAIDEHNAEAQESFGKNLNSLFNNME------ELIKDGSAKQKAMLD--- 560

  Fly   572 VNSSYVSQRLALN-SSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQ---------HSQAFV 626
                 |.:.|..| .|.|:..|..:...:|:...::...:...|.:|||.         .|::.:
Mouse   561 -----VHKTLFGNLMSSSVSALDTITTTALESLVSIPENVSARVSQISDMILEEQSLAAQSKSVL 620

  Fly   627 AKLMEQMQQQQ---------------LLMSKEIQTNLQ---VIEENNQRHKAMLDSMQEKFATII 673
            ..|::::....               |.::|::|...:   .:.|..:..|..:||    |.:|:
Mouse   621 QGLIDELVTDLFTSLKTIVAPSVVSILNINKQLQHIFRASSTVAEKVEDQKREIDS----FLSIL 681

  Fly   674 DSSLQSVEEHAKQMHKKLEQL-GAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIK 737
            .::|..:.|:......:.::| |.::    |:|:.::|..:.|  |.|...:..|......::.:
Mouse   682 CNNLHELRENTVSSLVESQKLCGDLT----EDLKTIKETHSQE--LCQLSSSWAERFCALEKKYE 740

  Fly   738 NLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLD 802
            |::..        ||.::|:...|:   .||.:....:.|..:..|.....||....:.|...::
Mouse   741 NIQKP--------LNSIQENTELRS---TDIINKTTVHSKKILAESDGLLQELRHFNQEGTQLVE 794

  Fly   803 QGVANCSMLQVHMKNLNQKYEKETNENVGSVR---VHHNQVEIIC-QESKQQLEAVQE------- 856
            :.|.:||.|..:::.::|    |..:..|::.   ||.:.....| .:.|::||.:.|
Mouse   795 ESVGHCSSLNSNLETVSQ----EITQKCGTLNTSTVHFSDQWASCLSKRKEELENLMEFVNGCCK 855

  Fly   857 KTEVNLEQMVDARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQELVRFQQ 921
            .:...:.:.|..:...:......|:...|...:..:..:.:..:..:....:|. |      |.:
Mouse   856 ASSSEITKKVREQSAAVANQHSSFVAQMTSDEESCKAGSLELDKTIKTGLTKLN-C------FLK 913

  Fly   922 SELKTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYRQELDWSDLDTTATIDECSEGEHDVSMH 986
            .:||...|||.||.::.::||.|||.|.|.::::.:.:::.....|:::....|.|: :.|....
Mouse   914 QDLKLDIPTGMTPERKKYLYPTTLVRTEPREQLLDQLQKKQPPMMLNSSEASKETSQ-DMDEERE 977

  Fly   987 SVQELSETETIMNSTPIEPVDGVTVKRGC---------GTTRNSNSNALKPPVATGGKRSS--SL 1040
            ::::.:| |.:...|...|....:..||.         |  ::..:..|.|......:.:|  |:
Mouse   978 ALEQCTE-ELVSPETTEHPSADCSSSRGLPFFQRKKPHG--KDKENRGLNPVEKYKVEEASDLSI 1039

  Fly  1041 SRSLTPSKTS 1050
            |:|..|..||
Mouse  1040 SKSRLPLHTS 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	210/353 (59%)
		SMC_prok_B	<408..728	CDD:274008	77/359 (21%)
		SMC_prok_B	<651..>921	CDD:274008	49/281 (17%)
		Microtub_bind	923..>1004	CDD:464048	21/80 (26%)
Kif11	NP_034745.1	KISc_BimC_Eg5	15..367	CDD:276815	210/353 (59%)
		PRK12704	349..>508	CDD:237177	76/177 (43%)
		CCDC158	415..>863	CDD:464943	104/504 (21%)
		Microtub_bind	915..1047	CDD:464048	32/135 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	950..1026		12/79 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1033..1052		7/17 (41%)