Protein Alignment Klp61F and KIF18B

DIOPT Version :9

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_011522687.1
• Gene: KIF18B / 146909
• HGNCID: 27102
• Length: 873
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 189/615 - (30%)
• Similarity: 272/615 - (44%)
• Gaps: 143/615 - (23%)

  Fly    17 NQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTR----------------HTLDSKLTK--K 63
            :..:||.|||||...||...:...||.||..|.:|..                |....|..|  .
Human    14 DSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPGLKWGGTHDGPKKKGKDLT 78

  Fly    64 FTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDD 128
            |.|||.||..:.|.||:......:::..|.||||:|||||.||.||||||:|.|
Human    79 FVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGRE----------- 132

  Fly   129 SDIGIIPRALSHLFD--ELRMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVI 191
            .|.||:......|:.  |.|..|..:.:.|||.|:|||::.|||.......||  :|..|  .|:
Human   133 GDPGIMYLTTVELYRRLEARQQEKHFEVLISYQEVYNEQIHDLLEPKGPLAIR--EDPDK--GVV 193

  Fly   192 IQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEG-EDMLKIG 255
            :|||......|.:.:.::|.:|...|....|..||.|||||.:|.|.|. :::.:.| ...:::.
Human   194 VQGLSFHQPASAEQLLEILTRGNRNRTQHPTDANATSSRSHAIFQIFVK-QQDRVPGLTQAVQVA 257

  Fly   256 KLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD---RAPHVPYRESKLTRLL 317
            |::|:||||||..|.. :.||.|:||..|||:|||.|..|:.||.|   |..|||||:|||||||
Human   258 KMSLIDLAGSERASST-HAKGERLREGANINRSLLALINVLNALADAKGRKTHVPYRDSKLTRLL 321

  Fly   318 QESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKT-------VLKEY 375
            ::||||..:|.:||.|||.....|:|.:||:||.|||.|        :|:.|:       .:.:|
Human   322 KDSLGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEI--------RLSLKSNVTSLDCHISQY 378

  Fly   376 TEEIDKLKRDLMAARDKNGIYLAEETYGE--------------------------------ITLK 408
            .....:|:.::.|.|.|..:|   |..|:                                .|.:
Human   379 ATICQQLQAEVAALRKKLQVY---EGGGQPPPQDLPGSPKSGPPPEHLPSSPLPPHPPSQPCTPE 440

  Fly   409 LESQNRELNEKMLLLKA---------LKDELQNKEK----IFSEVSMSLVEK--TQELKKTEENL 458
            |.:..|.|.|:.|.::|         ..|:.|:.|.    ...||...:.|:  |..|.::....
Human   441 LPAGPRALQEESLGMEAQVERAMEGNSSDQEQSPEDEDEGPAEEVPTQMPEQNPTHALPESPRLT 505

  Fly   459 LNTKGTL--------------LLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADL 509
            |..|..:              .|..|||...:|:|                      .:|.||:|
Human   506 LQPKPVVGHFSARELDGDRSKQLALKVLCVAQRQY----------------------SLLQAANL 548

  Fly   510 ATDDTHQLHGTIERRRELDEKIRRSCDQFK 539
            .|.|......|:::..: :|||....:..:
Human   549 LTPDMITEFETLQQLVQ-EEKIEPGAEALR 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	146/371 (39%)
		Kinesin	25..356	CDD:278646	142/354 (40%)
		Microtub_bind	923..>1009	CDD:290642
KIF18B	XP_011522687.1	KISc_KIP3_like	16..360	CDD:276821	145/360 (40%)
		KISc	18..367	CDD:214526	148/373 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910