Protein Alignment Klp61F and Kif3C

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_319556.6
• Gene: Kif3C / 1279749
• VectorBaseID: AGAMI1_002288
• Length: 750
• Species: Anopheles gambiae
• Alignment Length: 749
• Identity: 237/749 - (31%)
• Similarity: 353/749 - (47%)
• Gaps: 153/749 - (20%)

  Fly    18 QNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLT------------KKFTFDRSF 70
            :|::|.||.||:|.||:......|:.:            |:.|.            |.|.||.::
Mosquito     4 ENVKVVVRCRPMNKREQQSNCKSVIQI------------DNSLVNLDNPNDPNASQKSFQFDNAY 56

  Fly    71 GPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDD-SDIGII 134
            |..:...::||.:...|:|.||.|||.|:|||||||.||:|||.|. |..|.::..:: ::||||
Mosquito    57 GYAATTENIYSDICYSLVESVLEGYNATIFAYGQTGCGKSHTMQGT-TYNLSAADPNNANNIGII 120

  Fly   135 PRALSHLFDELRM-MEVEYTMRISYLELYNEELCDLL------STDDTTKIRIFDDSTKKGSVII 192
            ||:..|:|:.:.: .||.|.:.:||||:|||.:.|||      :|..|.:|:    ......|::
Mosquito   121 PRSFEHIFEAISLASEVRYLVLVSYLEIYNETIRDLLQPQSPAATASTLQIK----EVPGEGVMV 181

  Fly   193 QGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGED--MLKIG 255
            |.|....||......:|||.|.:.|....||||.:|||||::|||.:......:||:.  .:|.|
Mosquito   182 QNLSLHTVHGMKQCIELLEAGAKNRMVGATLMNIESSRSHSIFSISLEQMSTSVEGDSGVAIKRG 246

  Fly   256 KLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQE 319
            |||||||||||..||.| ..|.|::|...||.||..||.||:|||| :..|:|||:||||||||:
Mosquito   247 KLNLVDLAGSERQSKTG-ATGDRLKEATKINLSLSALGNVISALVDGKTRHIPYRDSKLTRLLQD 310

  Fly   320 SLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKR 384
            ||||.|||.:||.|||...:.:||||||.||.|||||.|||.||:. .|.|:|:||.:||.:||
Mosquito   311 SLGGNTKTLMIACISPADYNYDETLSTLRYASRAKNIANKPRVNED-PKDTMLREYQQEIMRLK- 373

  Fly   385 DLMAAR------------DKNGIYLAEETYGEITLKLESQ--------NRELNEKMLLLKALKDE 429
            :|:...            |.||:...::.       |.||        .||..::.:..:.|..:
Mosquito   374 ELLKGEGSTPPAAVNGHYDANGLDAEKQA-------LRSQYDQEVTHLRREYEQQRIAKQELVKD 431

  Fly   430 LQNKEKIFSEVSMSLVEKTQELKKTEENL-LNTKGTLLL---TKKVLTKTKR------------- 477
            :: |.|.:.|..|.|:..:::.....|.| .||....|.   .|::..:.|:
Mosquito   432 IE-KIKAYYEQQMQLLTSSRQQAADAEKLRQNTPAVALAGRDRKEIYDRIKQIKDALIGGERAND 495

  Fly   478 -RYKEKKELVASHMKTEQVLTTQAQ-----EILAAADLATDDTHQLHGTIERRRELDEKIRRSCD 536
             :.|||:  ..:.:.:|:.:...||     |..|..||.......:...::.|.|....:||...
Mosquito   496 IQLKEKR--YRNKLASEKRINALAQALGRIEQSADRDLLQGHYSDIQQELKVRYEQIRALRRRTK 558

  Fly   537 QFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSK-----SIEMLK--- 593
            ..:..:.|    |.|.....:|...|....|.::::....|.|:......|     ::|.|:
Mosquito   559 LLEQEVSD----IQGEFQRERDDYLATIRLLEKKVLFYETVFQKAMPVLRKDGRYWNLECLERES 619

  Fly   594 ----EMCAQSLQDQTNLHNKL----------------IGEVMKISDQHSQA-------------- 624
                ::....|.|.|.|..:|                :....|::.:.||.
Mosquito   620 EWNDDLRKWRLPDDTLLRLRLPPAETPPPAPSPPPSDVSSPGKLNGRESQTSLTAPGRLERSSTM 684

  Fly   625 FVAKLM-----------EQMQQQQLLMSKEIQTN 647
            |:|||.           ||.|::...:||...:|
Mosquito   685 FLAKLPEFQQHDRKPPDEQQQRKGDFLSKSTNSN 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	163/369 (44%)
		SMC_prok_B	<408..728	CDD:274008	61/324 (19%)
		SMC_prok_B	<651..>921	CDD:274008
		Microtub_bind	923..>1004	CDD:464048
Kif3C	XP_319556.6	None