Protein Alignment Klp61F and LOC1278752

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_061505800.1
• Gene: LOC1278752 / 1278752
• VectorBaseID: AGAMI1_011731
• Length: 1432
• Species: Anopheles gambiae
• Alignment Length: 1251
• Identity: 300/1251 - (23%)
• Similarity: 495/1251 - (39%)
• Gaps: 333/1251 - (26%)

  Fly    19 NIQVYVRVRPLNSRERCIRSAEVVDVVGPR----------------EVVTRHTLDSKLTKKFTFD 67
            :::|.|||||.|.||..:.:..:|.:.|.:                ::.:|..||.  ...||||
Mosquito     3 SLKVAVRVRPFNQREHELGAKLIVQMDGKKTRLLKPKLGTGNGVRGDLASRAALDP--FNDFTFD 65

  Fly    68 RSF------GPE-SKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSW 125
            .|:      .|. :.|..|:..:.:.:::....|||..||||||||:|||.||:|...|:
Mosquito    66 HSYWSVDERDPHFTHQETVFDDLGTEIVDCAFQGYNACVFAYGQTGSGKTFTMMGTPEAQ----- 125

  Fly   126 EDDSDIGIIPRALSHLFDELRMMEVE---YTMRISYLELYNEELCDLLSTDDTTK-IRIFDDSTK 186
                  |:|||....||..:::.:.|   |..:.||||:|||.:.|||....... :|:.:..|.
Mosquito   126 ------GLIPRICRSLFARMKLGQEEGTGYKTQCSYLEIYNERVKDLLGPSSAGHGLRVREHRTL 184

  Fly   187 KGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIV-VHIRE-NGIEGE 249
              ...::.|.:.||....::...:.:|..:|.||:|.||..|||||.:|:|. |..|. |.:..|
Mosquito   185 --GPYVESLSQHPVSDYSEIQNCMIQGNIQRTTASTNMNDTSSRSHAIFTITFVQARYLNDLPSE 247

  Fly   250 DMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD--------RAPHV 306
               .:.|::||||||||..:..| ..|.|::|..:||:||:|||.||:||.:        |..::
Mosquito   248 ---TVSKIHLVDLAGSERANATG-ATGQRLKEGAHINKSLVTLGSVISALAEQTNPTNNKRVLYI 308

  Fly   307 PYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTV 371
            |||:|.||.||::||||.:||.:||.|||...:..||||||.||:|||||.|||.:|:....| :
Mosquito   309 PYRDSILTWLLKDSLGGNSKTIMIAAISPADVNYSETLSTLRYANRAKNIINKPTINEDPNVK-L 372

  Fly   372 LKEYTEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKD--ELQNKE 434
            ::|..:||.|||  ||.:.|...             :||.|          ||.|:|  :.:.:|
Mosquito   373 IRELRDEIYKLK--LMLSSDSGA-------------ELEPQ----------LKVLEDLHKKEAQE 412

  Fly   435 KIFSEVSMSLVEKTQELKKTEENLLNTKGTLLLTKK----VLTKTKRRYKEKKELVASH--MKTE 493
            |:.:|   ...||.:|    .:::|..:.:|.|.|.    ||.      .|...|:..|  :.|.
Mosquito   413 KVLTE---EWTEKWRE----AQSILREQRSLGLRKSGVGVVLD------SEVPHLIGIHDDISTG 464

  Fly   494 QVLTTQAQEILAAADLATDDTH-----QLHG-----------------TIERRRELDEKIRRSCD 536
            ..|.:..:   ....:.||:..     .|:|                 ||.........:..|..
Mosquito   465 VTLYSLKE---GETTIGTDEAPYPQDISLNGIGIAPEHCRIVLSNGNATIYPNPNATCLLNASII 526

  Fly   537 QFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKE-MCAQSL 600
            :....:.....::.|..|:::....|...::.||..:....| ||.|:....|...:| :||..:
Mosquito   527 EVPTAISQGDILLLGRTNMFRYNNPAEAAKMRQESSHQQRAS-RLDLSRLSLIAASRENLCASFM 590

  Fly   601 QDQ----TNLHNKLIG-------------------------EVMKISDQHSQAF--VAKLMEQMQ 634
            .|.    :.....|.|                         |..::.|:|.:..  :...:.|:.
Mosquito   591 SDDDGGVSGSSLSLFGGGGGGGGGMASPQGAFRFRQYTPSREDAELQDEHRKILQTIENALRQLN 655

  Fly   635 QQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSV-----------EEHAKQMH 688
            .::..|.::.:..:::..|..:|    |:|.:....|::|..:..:           .....|:.
Mosquito   656 LERTRMHEQFKHKIRLCTEELER----LESTKRDRLTVLDCRIGELMARKEMVLWEKSNEKTQVD 716

  Fly   689 KKLEQLGAMSLP-----------DAEELQNLQ-----EELANE--RALAQQEDALLESMMMQM-- 733
            ..:.||.|:...           .|:|||.||     :|.::|  |...|.||  ...:::|:
Mosquito   717 ILVRQLSALQTQLDTKKRDFYEYVAKELQELQDCGRLDEASSELIRNAPQTED--YSEILLQISR 779

  Fly   734 -------EQIKNL--RSKNSIS-MSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQ---S 785
                   :.||..  |:::.|: ....|::.|:.......:|.|:...|.:.::...|..|   .
Mosquito   780 SLDNYSQQYIKEFVRRNRDEINKYEAELSEKEQQLAQSTQKIADLDQKIMELEQQNRELLQQRTQ 844

  Fly   786 AQAELTSQMEAGMLC-------LDQG--------------------------VAN--CSMLQV-- 813
            .:.||..|.:.||..       .|:|                          .||  ||.:..
Mosquito   845 QELELIQQKKLGMTLNLTHTNGADEGEGTGEQAGLLLGTNRAGTLETCDTFHTANSDCSFVSALN 909

  Fly   814 --HMKNLNQ-------------------KYEK-------------------ETNENVGSVRVHHN 838
              .:.:|||                   .||:                   |||....:....|.
Mosquito   910 TPALNSLNQLIPTPSSTEDGTESDTGDRDYEEATSNGGLLHGGMSDSGVSFETNRATDTAAALHT 974

  Fly   839 QVEIICQESK----QQLEAVQEKTEVNLEQMVDARQQLITED--RQRFIGH---ATVATDLVQE- 893
            :.:.  .||:    :|.......|...|.|..|....|.|..  ..::.|.   .|..|.:|.:
Mosquito   975 EADE--NESEGSVDRQSSGAASGTAKLLFQSDDHCLLLATSSTPNPKYGGKKLPTTTTTVIVTDG 1037

  Fly   894 -----SNRQFSEHAEHQRQQLQICEQELVRFQQSELKTYAPTGTTPSKRDFVYPRTLVATSPHQE 953
                 ||:|..:.:...|.:....|:|     ::.:.|.:..||..|.|       |..:.|:
Mosquito  1038 GGLLKSNQQQPQQSPRMRHKSSDSEEE-----RTTVTTMSSIGTPGSNR-------LKLSVPN-- 1088

  Fly   954 IVRRYRQELDWSDLDTTAT-IDECSEGEHDVSMHSV----------QELSETETIMNSTPIEPVD 1007
               |.|...:.|...:..| |.:...|.|.:.:.||          :|..|.:........:.||
Mosquito  1089 ---RNRSNSNNSKSSSMRTEIFDIRHGIHPLRVSSVSSGTDGSHEEEEYEEEDAHGRRRHRQEVD 1150

  Fly  1008 GVTVKRGCGTTRNSNS 1023
            ....:|..|::.:::|
Mosquito  1151 DEEERRSRGSSIDNSS 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	142/382 (37%)
		SMC_prok_B	<408..728	CDD:274008	74/410 (18%)
		SMC_prok_B	<651..>921	CDD:274008	73/405 (18%)
		Microtub_bind	923..>1004	CDD:464048	18/91 (20%)
LOC1278752	XP_061505800.1	None