Protein Alignment Klp61F and Klp31E

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_061516566.1
• Gene: Klp31E / 1278143
• VectorBaseID: AGAMI1_013230
• Length: 1675
• Species: Anopheles gambiae
• Alignment Length: 1194
• Identity: 306/1194 - (25%)
• Similarity: 501/1194 - (41%)
• Gaps: 283/1194 - (23%)

  Fly    12 PQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQ 76
            |.:....:::|.||:||...|| .|....|...|.|.|.......|    |.||||..|...:.|
Mosquito     2 PDEDKESSVRVAVRIRPQIPRE-LIDMCRVCTQVTPGEPQVLLGSD----KAFTFDYVFDMSTTQ 61

  Fly    77 CDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTM-VGNETAELKSSWEDDSDIGIIPRALSH 140
            ..||:..:..|::..|.|||.||.||||||:|||:|| .|.|.| |..:.|     ||||||:.|
Mosquito    62 VSVYNNCIEKLVDGALQGYNATVLAYGQTGSGKTYTMGTGFERA-LPEAQE-----GIIPRAVRH 120

  Fly   141 LFDELRMME-------------VEYTMRISYLELYNEELCDLLSTDDTTK----IRIFDDSTKKG 188
            ||:.:..::             |.:::...::||||||:.|||  |...|    .:||:|:|  |
Mosquito   121 LFEGIAQLQQNPYDEDGTYLGTVTFSVAAQFMELYNEEVIDLL--DPYNKGARVFKIFEDAT--G 181

  Fly   189 SVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRE-------NGI 246
            .:.:.|....|:....:....|::|...|.||:|.||.||||||.:|:|::..:.       ...
Mosquito   182 GISVAGATIKPLAGPQEALNCLQQGALARTTASTQMNEQSSRSHALFTILIRRQRVMTAEQCGNA 246

  Fly   247 EGEDMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD---RAPHVPY 308
            ||:......|.:.|||||||.:.:.| ..|.|.||.::||..||.||.||:||.|   :..||||
Mosquito   247 EGDTETLTSKFHFVDLAGSERLKRTG-ATGERAREGISINCGLLALGNVISALGDKTKKVSHVPY 310

  Fly   309 RESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLK 373
            |:||||||||:||||.::|.:||.:||..:|..|||:||:||:||:||:||.::||..:.:|: .
Mosquito   311 RDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVQINQDQSSRTI-S 374

  Fly   374 EYTEEIDKLKRDLMAARD-KNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIF 437
            ....||..|:.:::..:. |..|    :..|.|.:...|...|      :|......||.:.|..
Mosquito   375 LLRREIANLQLEILEYKQGKRSI----DADGNIAISDVSLENE------MLSQDNKRLQQRVKAM 429

  Fly   438 SEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQE 502
            .|...:|.||...|                             :.::.:||..|..
Mosquito   430 QETINALTEKNAAL-----------------------------QAQQTIASLHKAS--------- 456

  Fly   503 ILAAADLATDDTHQLHGT--------------------IERRRELDEKIRRS---CDQFKDR--- 541
              ||.|...|.|...:|:                    |....:|..|:..|   ..|||..
Mosquito   457 --AAGDGGADATSTNNGSSPVGTAGGNDSAMQELIVGYISEIEKLKAKLIESEQMFQQFKKAKSS 519

  Fly   542 -----------MQDNLEMIGGSLNLYQDQQAALKEQL-SQEMVNSSYVSQRLALNSSKSIEMLKE 594
                       ::||.|.:   :|:.:.:....:|.| |:.:....:.|..:..||....:...:
Mosquito   520 QSKLGIKTYPFIEDNPETM---INMLKHEMEKERETLMSRSLPGLEHESSSMDQNSDSDSDTESD 581

  Fly   595 MCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEE---NNQ 656
            ..|:.|:.:.:..|..|...:::.:|         :|:.||:..:|.::.:....:::|   |.:
Mosquito   582 DKAEVLRAEMSDVNSDIELKVRLIEQ---------LEESQQRLQIMRQQYEKQFNLMKEKISNTE 637

  Fly   657 RHKAMLDSMQEKFATI----------------IDSSLQSV-EEHAKQMHKKLEQLGAMSLPDAEE 704
            |.:      .|..|||                .:::::.| |::.:::::...||......:.|.
Mosquito   638 RER------DEVLATIGNGGTGAMNNKGQNSGNETAIKRVKEDYERKLNELRRQLNHFQATNKEH 696

  Fly   705 LQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSK--NSISMSVHLNKMEESRL-------- 759
            |: ||..:       |.:||.::::..::.::|.::::  ..|....:.:|..|||.
Mosquito   697 LR-LQRNM-------QAQDAKIKTLRGELAELKQVKTRLMKKIQEESNRHKEMESRKTREIAQLR 753

  Fly   760 --TRNHRIDDIKSGIQDYQKLGIEASQ-------------SAQAELTSQMEAGMLCLDQGVANC- 808
              ||.|     |:.|:..|..|....|             .:|..:.|...||.:   ||..:.
Mosquito   754 KETRKH-----KNMIKSLQAQGAAKDQVLKRKTEEVFNLRKSQRGIMSLKAAGRV---QGNTSIG 810

  Fly   809 SMLQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVDARQQLI 873
            |||| ..|....::|:.....:.:.|.....:|:     :.:||.|.::.:|....:.:.||
Mosquito   811 SMLQ-GTKRFKSRWEELQRSIMRAARTRQAVLEL-----EMELERVMQERDVLSRDLTNLRQ--- 866

  Fly   874 TEDRQRFIGHATVATDLVQES-------NRQFSEHAEHQRQQLQICEQELVRFQQSELKTYAPTG 931
               |::....:|: .|||.|.       |.......|.|:..:||.:.:.:..:...|:|.....
Mosquito   867 ---RRKDNAESTL-QDLVSEEDTIIANMNYLHDTITELQKSIIQIEDGKDLNSEHLMLQTIMENI 927

  Fly   932 TTPSKRDFVYPRTLVATSPH---QEIVRRYRQELD--WSDLDTTATIDE----------CSEGEH 981
            .|..:..|:..|....|..|   ..:.:...:|.|  .::|....::.|          .:....
Mosquito   928 GTVEEAKFMLQRVCTVTIGHVCEAGVAQSKLRERDALLTELQRDTSVQEQLLQYILTRAPAASAS 992

  Fly   982 DVSMHSVQEL------SETETIMNSTPIEP-----------VDGVTVKRGCGTTRN---SNSNAL 1026
            |.|..|.|..      |:...:.|..| :|           ||        .|||:   |:||..
Mosquito   993 DASFSSAQSANSYATQSQANLLENGEP-QPSSSQQYRLPHVVD--------STTRSPSPSSSNTN 1048

  Fly  1027 KPPVATGGKRSSSLSR---SLTPS 1047
            ...:.|  .|:||..|   |:.||
Mosquito  1049 LDSIVT--YRNSSKQRRNPSVVPS 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	152/375 (41%)
		SMC_prok_B	<408..728	CDD:274008	64/377 (17%)
		SMC_prok_B	<651..>921	CDD:274008	63/322 (20%)
		Microtub_bind	923..>1004	CDD:464048	18/101 (18%)
Klp31E	XP_061516566.1	None