Protein Alignment Klp61F and LOC1277078

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_061498142.1
• Gene: LOC1277078 / 1277078
• VectorBaseID: AGAMI1_012463
• Length: 2263
• Species: Anopheles gambiae
• Alignment Length: 1260
• Identity: 302/1260 - (23%)
• Similarity: 530/1260 - (42%)
• Gaps: 301/1260 - (23%)

  Fly    17 NQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYS 81
            :.|::|.::||||..||   |..::|.....|:.:.. |:|.. ...|.||..|........::.
Mosquito     2 SDNVKVSIKVRPLIKRE---RENKLVSQWRIRDNIIA-TIDGN-GDPFVFDHIFDETVPTRQLFD 61

  Fly    82 VVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFDEL- 145
            .|..|:|...|||.|.|:||||||.:|||:||:||           |.:.|::|.....:|:::
Mosquito    62 TVCRPVILSALNGINGTIFAYGQTSSGKTYTMIGN-----------DREPGVVPLTAREIFEQIK 115

  Fly   146 RMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKLL 210
            |:.|.::.:|:.::|:|||::.|||:|.: |.::|.::..  |.|.:...|.| .:..:.:.:.:
Mosquito   116 RIKERQFLIRVGFIEIYNEKIHDLLNTAN-TNLKIVENQC--GDVSVNSKECI-TNCAEQIIQHV 176

  Fly   211 EKGKERRKTATTLMNAQSSRSHTVFSIVVHIR----ENGIEG---EDMLKIGKLNLVDLAGSENV 268
            :.|.:.||...|.||.:||||||:|.|.:..|    .||::|   .:.::||.||||||||||..
Mosquito   177 DDGNKARKIGETNMNERSSRSHTIFRITIESRVIGPANGVDGGMDNEAVQIGILNLVDLAGSERA 241

  Fly   269 SKAGNEKGIRVRETVNINQSLLTLGRVITALVDRA--PHVPYRESKLTRLLQESLGGRTKTSIIA 331
            .:.| ..|.|.:|.|.||:|||:|..||..|.:.:  ..:.||:|||||:||.||||...||:|.
Mosquito   242 DQTG-ATGSRFKEGVCINKSLLSLSCVIQKLSENSDKQFINYRDSKLTRILQASLGGNAVTSMIC 305

  Fly   332 TISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAARDKN--- 393
            .|:|.  .::||..||.:|.|||||:|||:||:.||...::|....||.:|:.:|.:.::||
Mosquito   306 NITPA--VVDETYYTLSFAMRAKNIRNKPKVNEILTDAAMMKRLEREIKRLQSELRSEQNKNSKI 368

  Fly   394 ----------------------------------------------------------------- 393
                                                                             
Mosquito   369 KTMELQNAITLRTNQFINSNQAQQSLADNARRRTWCPSTTEIPRLAPGHRPTPDLMGEGGRTLMG 433

  Fly   394 --------GIYL----------------AEETY-----GEI--------TLKL------ESQNRE 415
                    |.||                |:|.|     |:|        ||.|      ..|.||
Mosquito   434 PPPAVTNGGQYLVTMNGATPQIAIRSMSADEDYVATRSGDIRASDGFAATLALIGEDEPNIQYRE 498

  Fly   416 -LNEKMLLLKALK---------------DELQNKEKI-FSEVSMSLVEKTQELKKTEENLLNTKG 463
             |:.:.||.:.::               ||....|:| |...|:|.:       .|.|..|:|..
Mosquito   499 LLDHQDLLARRVRSTSPNGLLNPFSSYGDEFVPGEQISFGSASVSPL-------STMERELHTPK 556

  Fly   464 TLLLTKKVLT-------KTKRRYKE-KKELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGT 520
            :|..|::..|       ..::|.:| ::||:.....|:...:.:.|.:....|..|.:..:|...
Mosquito   557 SLRRTRRSSTGDSPPQFNFEQRCRELEQELLELQEFTKLENSVETQHLKKELDKRTGELSELKHD 621

  Fly   521 IERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLN----LYQDQQAALKEQLSQEMVNSSYVS--- 578
            :|::.:..|::...|.|.:..::..:..:..:.|    ..:::|||::|   .|:..:.:..
Mosquito   622 LEKKEQRLEQLEERCAQLEVELKGQMATVSKAENDLALAVKERQAAVRE---AELHRNQHTGIEF 683

  Fly   579 ------QRLALNSSKSIEMLKEM----CAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQM 633
                  ||......:.||.|:|.    ...:..|...|..|  .|.||..:..:..|..:|.|..
Mosquito   684 EYERYRQRSEAREKELIESLQEARNNGATSNGGDSFKLDQK--REEMKRLEMQNYEFTLQLEECN 746

  Fly   634 QQQQLLMSKEIQTN--LQVIEENNQRH----------KAMLDSMQEKFATIIDSSLQSVEEHAKQ 686
            :|.:.|.|..::.:  |:::::...:|          .|:::|:::......|...|   ||..|
Mosquito   747 KQLEQLKSSNLEQHRKLEIVKQAVLQHYQTLSGDFPQSALVNSLRKLLLLSPDGGEQ---EHTAQ 808

  Fly   687 MH---------KKLEQLGAMSLPDA-----------EELQNLQEELANE-RALAQQEDALLESMM 730
            .:         ..|:..|..::.|.           :||..:.|:|... |||.|::.||.|:..
Mosquito   809 SNGFNDTTMGQSVLDGNGNATMLDGNATLMGEEKTIQELVKIVEQLEETIRALEQEKRALQEASD 873

  Fly   731 MQMEQIKNLRSKNSIS---MSVHLNKMEESRLTRNHRIDDIKSGI-------QDYQKLGIEASQS 785
            :|:.::|:.......|   :...:.:..|....:....|::.:.:       :|.:|...||.|:
Mosquito   874 VQLGELKSKLDGGQTSIERLEKEIAQWREKFAAQTTEYDELSTQLMDQMQDNEDLRKQFEEAKQT 938

  Fly   786 AQA-----ELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQ 845
            |.|     :...::|..|..|.:.:...:..:..::.:.....:|.:....|:..|.:|||.|..
Mosquito   939 ALANEKDVQRREELEREMGPLRESLEKANAEREALQRVCDSLREEVSALKASIESHASQVETIVA 1003

  Fly   846 ESKQQLEAVQEKTEVNLEQMVDARQQLITE-------------------DR--------QRFIGH 883
            | |:||...:::.::.||:.:..:::.:.|                   ||        :..||.
Mosquito  1004 E-KEQLSVERDEVKIRLEEAITKQKETMKELETVQAAKQAEVATVNEEIDRLKQEIVKLETSIGE 1067

  Fly   884 ATVATDLVQESNRQFSEHAE--HQRQQL------QICEQELVRFQQSELKTYAPTGTTPSKRDF- 939
            .:|..:|:...|.:.|....  .:.|||      |...::|.|.||  ||..|.......:.:.
Mosquito  1068 QSVEKELLATENSRLSAQLVQLQKEQQLAGAASDQKAREDLQRLQQ--LKDEADGRVVQLEVELE 1130

  Fly   940 VYPRTLVATSPHQEIVRRYRQELDWSDLDTTATIDECSE-----GEHDVSMHSVQELSETETIMN 999
            |:...|.|....|.  .|::|   | :.:....:.|..|     .|...|:|.::|...::|  |
Mosquito  1131 VFKNKLDAAESEQN--ERFQQ---W-EAEKQGLVKEIGELQLRMEELQASLHQLREEKNSQT--N 1187

  Fly  1000 STPIEPVDGVTVKRGCGTTRNSNSN 1024
            ...|:.....|::......|...::
Mosquito  1188 LVQIQTEKESTLQEQLAVLRQKQAS 1212

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	136/357 (38%)
		SMC_prok_B	<408..728	CDD:274008	80/400 (20%)
		SMC_prok_B	<651..>921	CDD:274008	65/350 (19%)
		Microtub_bind	923..>1004	CDD:464048	18/86 (21%)
LOC1277078	XP_061498142.1	None