Protein Alignment Klp61F and Klp61F

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_061499619.1
• Gene: Klp61F / 1269725
• VectorBaseID: AGAMI1_012015
• Length: 1101
• Species: Anopheles gambiae
• Alignment Length: 1063
• Identity: 500/1063 - (47%)
• Similarity: 670/1063 - (63%)
• Gaps: 100/1063 - (9%)

  Fly     1 MDISGGNTSRQP-----QKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREV-VTRHTLDSK 59
            ||.|.|.:.|..     :.|||||:||||||||.|:||:.|||.|||:||..||: :..:..||:
Mosquito     1 MDASNGTSERNQSNNAYRPKSNQNVQVYVRVRPTNAREKLIRSQEVVEVVSTRELQLKSNYTDSR 65

  Fly    60 LTKKFTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSS 124
            .:|||||||:|.|.|||.:||..||:|.|||||:|:||||||||||||||||||||.|...|.::
Mosquito    66 TSKKFTFDRTFAPNSKQHEVYQAVVAPYIEEVLSGFNCTVFAYGQTGTGKTHTMVGEEEQNLSAA 130

  Fly   125 WEDDSDIGIIPRALSHLFDELRMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGS 189
            ||||:..||||||::||||||||.|:|::||||||||||||||||||||||.|||||||..||||
Mosquito   131 WEDDTQTGIIPRAVNHLFDELRMTELEFSMRISYLELYNEELCDLLSTDDTIKIRIFDDVQKKGS 195

  Fly   190 VIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKI 254
            ||:||||||||||||||||||.||:||||||:||||||||||||:|||:|||:||||:||:||||
Mosquito   196 VIVQGLEEIPVHSKDDVYKLLAKGQERRKTASTLMNAQSSRSHTIFSIIVHIKENGIDGEEMLKI 260

  Fly   255 GKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQE 319
            |||||||||||||:||||||||||.|||||||||||||||||||||::.||:|||||||||||||
Mosquito   261 GKLNLVDLAGSENISKAGNEKGIRTRETVNINQSLLTLGRVITALVEKTPHIPYRESKLTRLLQE 325

  Fly   320 SLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKR 384
            |||||||||||||:|||:||.|||||||||||||||||||||.||||:||||:||||||||:|||
Mosquito   326 SLGGRTKTSIIATVSPGNKDFEETLSTLEYAHRAKNIQNKPEANQKLSKKTVIKEYTEEIDRLKR 390

  Fly   385 DLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMSLVEKTQ 449
            ||||||||||||||||||.|:..|.|:..:|||:|:.|:||||::|..||.||:||:.||.|:.:
Mosquito   391 DLMAARDKNGIYLAEETYNEMVYKSEAATKELNDKLALIKALKEDLARKEAIFNEVACSLAEREE 455

  Fly   450 ELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLATDDT 514
            :|::|.::|..|:..|..|||.|:||||||.|||.::..|:||||:||.||:|::...:..|:||
Mosquito   456 QLRRTADDLGQTRAELSNTKKNLSKTKRRYVEKKVILEHHLKTEQMLTGQAKELINVVESVTEDT 520

  Fly   515 HQLHGTIERRRELDEKIRRSCDQFKDR-------MQDNLEMIGGSLN-----------LYQDQQA 561
            :.||.|::||||||.:.:.:.:||.||       :||::..:....|           .|..||.
Mosquito   521 NGLHDTVDRRRELDSRNKSATEQFVDRVRHRIGTIQDDVSKMADECNRLTVDMNVGWESYNKQQE 585

  Fly   562 ALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFV 626
            |...:....:.....||..|...::..:...|    .|::.:|....   .||::..||..|:.:
Mosquito   586 AAYIETKAHLSTLETVSHSLLQQNASLVGAFK----ASMEGKTEARR---DEVIQFLDQVEQSRL 643

  Fly   627 AKLME----QMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIID------SSLQSVE 681
            | |||    .|::.:|.:...|....:.::...:|..|...:.:.|.|....      :.|.|:.
Mosquito   644 A-LMETFTSTMEKLKLGIRTTIDAQHEQVQAQFERMIAHGQARESKCAEFCQTFTGQLAELDSIT 707

  Fly   682 EHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSIS 746
            ...::.|..|:...|.|      .|..|.||...:....:..:||...:.||......:::.| |
Mosquito   708 STFERNHTVLQDYVAQS------EQKKQNELKATKEFEAKVSSLLADFVQQMTASSQQQTELS-S 765

  Fly   747 MSVHLNKMEESRLTR-NHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSM 810
            :.||::....|:.|: ..::..|:|.|.  :|.|  ..|.:.||..|..:           .|:
Mosquito   766 VVVHVSDELVSQGTKATKQLQTIRSSID--EKRG--KVQESTAEWDSHAQ-----------ECA- 814

  Fly   811 LQVHMKNLNQKYEKETNENVGSV-----RVHHNQVEIICQESKQQLEAVQEKTE---VNLEQMVD 867
                  .|.|:::::..|.:.||     .|.:..:....::.:.:....||:|.   |...|..|
Mosquito   815 ------RLVQQHQRKVVEELASVDLSLAEVSNATLASTIEQQRTRASTAQEETRACVVEFAQQFD 873

  Fly   868 ARQQLITEDRQRFIGHATVATDLVQESNRQF-SEHAEH-QR--------------QQLQICEQEL 916
            .:.....:.::..||.|..:..:.|::..|| |.:..| ||              :||...:.:.
Mosquito   874 EQNGNFGQAQEEGIGRAMGSLQVQQQARAQFGSANCGHTQRIGQTVESFERRANEEQLAELQNDF 938

  Fly   917 VRFQQSELKTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYRQELDWSDLDTTATIDECSEGEH 981
            .||.:.:|..|..:|.||.::...|||.:..|||.:.|:||:.:|...:::|.:.||  |.:.|.
Mosquito   939 ERFHEKDLTFYQSSGKTPIRKKVQYPRDIAMTSPDERILRRFWRERGATEVDLSTTI--CEDMEE 1001

  Fly   982 DVSM-HSVQELSETETIMNSTPI 1003
            ...: .|:..:...| |.||||:
Mosquito  1002 ICPLERSITNIKAPE-IRNSTPL 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	279/348 (80%)
		SMC_prok_B	<408..728	CDD:274008	106/347 (31%)
		SMC_prok_B	<651..>921	CDD:274008	60/300 (20%)
		Microtub_bind	923..>1004	CDD:464048	27/82 (33%)
Klp61F	XP_061499619.1	None