Protein Alignment Klp61F and Khc-73

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_061519501.1
• Gene: Khc-73 / 1269637
• VectorBaseID: AGAMI1_014561
• Length: 1913
• Species: Anopheles gambiae
• Alignment Length: 1201
• Identity: 276/1201 - (22%)
• Similarity: 482/1201 - (40%)
• Gaps: 326/1201 - (27%)

  Fly    17 NQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVV----TRHTLDSKLTKKFTFDRSFGPESKQC 77
            :..|:|.|||||.|.||..:.:..|:::.|.:.::    :...::.|..|.|.||..|.......
Mosquito     2 SDKIRVAVRVRPFNRRELELATENVIEMNGTQTILKYPASLDKMERKPPKIFAFDHCFYSTDANA 66

  Fly    78 D-------VYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIP 135
            :       |::.:...::|....|||..:|||||||:||::||:|::.::           ||||
Mosquito    67 NNFASQELVFNNIGRDILENAFQGYNACIFAYGQTGSGKSYTMMGSQDSK-----------GIIP 120

  Fly   136 RALSHLFDEL---RMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSV------- 190
            |....||..:   :..|:.|.:.:||:|:|||::.|||           |..|.|.|:
Mosquito   121 RLCDELFASIAAKQTDELNYKVEVSYMEIYNEKVHDLL-----------DPKTAKQSLKVREHNV 174

  Fly   191 ---IIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVH----IRENGIEG 248
               .:.||.::.|.|..|:..|:.:|.:.|..|.|.||::|||||.||::|:.    ...:|:.|
Mosquito   175 LGPYVDGLSQLAVTSFLDIDNLMAEGNKSRTVAATNMNSESSRSHAVFTVVLTQTLIDTLSGVTG 239

  Fly   249 EDMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD------RAPHVP 307
            |   |:.:::||||||||...|.| ..|.|::|..|||:||.|||.||:.|.|      :...||
Mosquito   240 E---KVSRVSLVDLAGSERAVKTG-AVGDRLKEGSNINKSLTTLGLVISKLADSTGGKNKDKFVP 300

  Fly   308 YRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVL 372
            ||:|.||.||:::|||.::|.::||:||...:.|||||||.||.|||.|.|...||:....: ::
Mosquito   301 YRDSVLTWLLKDNLGGNSRTVMLATLSPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAR-II 364

  Fly   373 KEYTEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIF 437
            :|..:|::.|:..|..|...|        :|::      :..::::|:.       |.:|..|..
Mosquito   365 RELRKEVETLREMLKHATGSN--------FGDM------KRVDIHDKLA-------ESENLMKQI 408

  Fly   438 SEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRY-------KEKKELVASHMKTEQV 495
            |:.....:|||::::...:..|...|..:....:..:..:.|       ....||:..::|.|.:
Mosquito   409 SQTWEEKLEKTEQIQSERQQALEKMGISVQDSGIKVEKNKYYLVNLNADPSLNELLVYYLKEETL 473

  Fly   496 LTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSL------- 553
            :.                                  .||....|   |.:::::|..:
Mosquito   474 IG----------------------------------GRSSSGSK---QPDIQLLGLGIQPEHCLI 501

  Fly   554 -----NLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSI-----EMLKEMCAQSLQDQTNLHN 608
                 .||.|     ..:.::..||.|.||.::||:....|     ...:..|.:|..:.|.|.
Mosquito   502 TIEDGELYMD-----PIENARCYVNGSVVSDKMALHHGDRILWGNHHFFRVNCPKSATNSTALG- 560

  Fly   609 KLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATII 673
               ....:...||...:.|:  |::.|.: |.:..||..:..:|:.::..|.:          .:
Mosquito   561 ---ASEPQTPAQHMDYYYAQ--EELMQNE-LSNNPIQAAISRLEKQHEEDKQV----------AL 609

  Fly   674 DSSLQSVEEHAKQMHKKLE--------------QLGAM--SLPDAE----------------ELQ 706
            :...|..|:..:|:...|.              :||.:  :.|.|:                .|.
Mosquito   610 EKQRQEYEKQFQQLRNILSPTTPYAPYAPYDPFRLGKLPPNTPTAQLRVEKWAQERDEMFKRSLG 674

  Fly   707 NLQEELANERALAQQEDALLESMMMQME-----QI--KNL-----------------RSKNSISM 747
            .|:.::....||.|:.:.|.|.|..|.:     ||  .||                 |..||.|.
Mosquito   675 QLKTDIVRANALVQEANVLAEEMDKQTKFSVTLQIPPANLSPNRKRGAFVSEPAILVRRMNSGSQ 739

  Fly   748 SVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAE----LTSQMEAGMLCLDQGVANC 808
            ...:.|:|       :::.|::...|||::....|.:.|:|:    ..||....::    ||||.
Mosquito   740 IWSMEKLE-------NKLIDMRDMYQDYKERHQAAMEEAKAKSDPFYESQENHNLI----GVANI 793

  Fly   809 SMLQVHMKNLNQKYE----KETNENVGSVRVHHNQV------EIICQESKQQLEAVQEKTE---- 859
             .|:|...::...|.    .:..|..|.::|..::|      :.:|:.:.:......|..|
Mosquito   794 -FLEVLFHDVKLDYHTPIISQQGEVAGRLQVEISRVAGTFPQDRMCESASESSADSHEDDEDSPD 857

  Fly   860 -------VNLEQM---VDARQ-----------------------QLITEDRQRFIGHATVAT--- 888
                   .|..|:   :..:|                       .::....|...||....|
Mosquito   858 TPSPPPPTNSNQISCRISIKQASGLPLYLSNFVFCQYSFWNHEVAVVPATNQEVAGHNQNITFKF 922

  Fly   889 ----DLVQESNRQFSEHAEHQRQQLQICEQELVRF----------QQSELKTYAPTGTTPSKRDF 939
                |.:...|.:|.||.......:::.....|.|          ||::.::.|......|::..
Mosquito   923 DHEADYIVTMNEEFLEHCSDGALSIEVWGHRSVGFSRMKDWEVEQQQAKARSLADRWAELSRKIE 987

  Fly   940 VYPRTLVATSPHQEIVRRYRQELDWSDLDTTATIDECSEGEHDVS-------MHSVQELSETETI 997
            ::..           :.......||:.::.....|..:.|.:.:.       |..|:.:..:.|:
Mosquito   988 LWVE-----------IHELNDNGDWAPVEVQCARDMLTGGVYQLRQGFQRRVMVRVKPVQNSGTL 1041

  Fly   998 MNSTPIEPVDGVTVKRGCGTTRNSNSNALKP 1028
                ||.....:.|..||.|.|   |...||
Mosquito  1042 ----PIICQSIINVSMGCVTVR---SKLQKP 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	139/381 (36%)
		SMC_prok_B	<408..728	CDD:274008	59/375 (16%)
		SMC_prok_B	<651..>921	CDD:274008	66/393 (17%)
		Microtub_bind	923..>1004	CDD:464048	10/87 (11%)
Khc-73	XP_061519501.1	None