Protein Alignment Klp61F and Kif1b

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_038965095.1
• Gene: Kif1b / 117548
• RGDID: 621520
• Length: 1825
• Species: Rattus norvegicus
• Alignment Length: 1043
• Identity: 251/1043 - (24%)
• Similarity: 443/1043 - (42%)
• Gaps: 244/1043 - (23%)

  Fly    16 SNQNIQVYVRVRPLNSRE-----RCI-----RSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSF 70
            |..:::|.|||||.||||     :||     .|..:::...|:|.          .|.|:||.|:
  Rat     2 SGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEA----------PKSFSFDYSY 56

  Fly    71 ----GPE----SKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWED 127
                .||    :.|..||:.:...::.....|||..:|||||||.||::||:|.         ::
  Rat    57 WSHTSPEDPCFASQSRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGK---------QE 112

  Fly   128 DSDIGIIPRALSHLFDELR---MMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGS 189
            :|..||||:....||:::.   ..::.|::.:||:|:|.|.:.|||:..:...:|:.:....  .
  Rat   113 ESQAGIIPQLCEELFEKINDNCNEDMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLL--G 175

  Fly   190 VIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIR----ENGIEGED 250
            ..::.|.::.|.|..|:..|::.|.:.|..|.|.||..|||||.||:||...:    |..:..|
  Rat   176 PYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKQDPETNLSTE- 239

  Fly   251 MLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD------------RA 303
              |:.|::||||||||.....| .||.|::|..|||:||.|||:||:||.:            :.
  Rat   240 --KVSKISLVDLAGSERADSTG-AKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKT 301

  Fly   304 PHVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTK 368
            ..:|||:|.||.||:|:|||.::|:::|.:||...:.:||||||.||.|||.|:....:|:....
  Rat   302 DFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNA 366

  Fly   369 KTVLKEYTEEIDKLKRDLMAARDKNGIY----LAEETYGEITLKLESQNRELNEKMLLLKALKDE 429
            |.| :|..||:.:|| ||:.|:....|.    |.::..|...                 |.|||.
  Rat   367 KLV-RELKEEVTRLK-DLLRAQGLGDIIDIDPLMDDYSGSGG-----------------KYLKDF 412

  Fly   430 LQNKEKI-----------FSEVSMSLVEKT------------QELKKTEENLLNTKG------TL 465
            ..||.:.           ||..||..:..:            ..:...:|.:::|.|      .|
  Rat   413 QNNKHRYLLASENQRPGNFSTASMGSLTSSPSSCSLNSQAGLTSVTSIQERIMSTPGGEEAIERL 477

  Fly   466 LLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRE---- 526
            ..::|::.:....::||       ::..:.:..:.:.:||...:|..:.....|....::.
  Rat   478 KESEKIIAELNETWEEK-------LRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLV 535

  Fly   527 ---------------LDEKIRRSCDQFKDRMQDNLEMIGGSLN----LYQDQQAALKE------- 565
                           :.:.|.|......:|.|| :.:.|..:.    :::.::....|
  Rat   536 NLNEDPLMSECLLYYIKDGITRVGQADAERRQD-IVLSGAHIKEEHCIFRSERNNTGEVIVTLEP 599

  Fly   566 -QLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQ-SLQDQTNLHNKLIGEVMKISDQHSQAFVAK 628
             :.|:..||...|:..:.|.|...|.|.|....: :..:|.....:........|:.....|..:
  Rat   600 CERSETYVNGKRVAHPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQR 664

  Fly   629 LMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQ 693
              |.:::|.:.|.:|::..||.:|...:|.|...|.:.|:.....:|.||:::   ||:..:  .
  Rat   665 --ELLEKQGIDMKQEMEKRLQEMEILYKREKEEADLLLEQQRLDYESKLQALQ---KQVETR--S 722

  Fly   694 LGAMSLPDAEELQNLQEEL---ANERALAQQEDALLESMMMQMEQIKNLRSKNSI------SMSV 749
            |.|.:..:.||    :||:   .:|..|||.  |..:....|...:::|...|::      ::||
  Rat   723 LAAETTEEEEE----EEEVPWTQHEFELAQW--AFRKWKSHQFTSLRDLLWGNAVYLKEANAISV 781

  Fly   750 HLNKMEE--------------------SRLTRNH------------RIDDIKSGIQDYQKLGIEA 782
            .|.|..:                    :.:.:.|            .:.|:|:|...|..|.
  Rat   782 ELKKKVQFQFVLLTDTLYSPVPPELLPTEMGKTHEDRPFPRTVVAVEVQDLKNGATHYWSLD--- 843

  Fly   783 SQSAQAELTSQM-----EAGMLCLDQGVANCSMLQVHMKNLNQKYEK-ETNENVGSVRVHHNQVE 841
            ....:.:|..:|     |.|....|..       :..|...:..|:: ...:.|||..:.|..|.
  Rat   844 KLKQRLDLMREMYDRAGEVGSNAQDDS-------ETTMTGSDPFYDRFHWFKLVGSSPIFHGCVN 901

  Fly   842 IICQESKQQLEAVQEKT--------EVNLEQMVDARQQLITE-DRQRFIGHATVATDLVQESNRQ 897
                      |.:.::|        :.::.::.|.:|..:.: |.:.|:.. |.:....:|.:..
  Rat   902 ----------ERLADRTPSPTFSTADSDITELADEQQDAMEDFDDEAFVDD-TGSDAGTEEGSEL 955

  Fly   898 FSE 900
            ||:
  Rat   956 FSD 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	135/384 (35%)
		SMC_prok_B	<408..728	CDD:274008	67/383 (17%)
		SMC_prok_B	<651..>921	CDD:274008	56/306 (18%)
		Microtub_bind	923..>1004	CDD:464048
Kif1b	XP_038965095.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	134/381 (35%)
		Kinesin_assoc	358..555	CDD:465047	35/222 (16%)
		FHA_KIF1B	530..639	CDD:438779	16/109 (15%)
		GimC	662..>719	CDD:440992	16/61 (26%)
		KIF1B	845..892	CDD:463574	8/53 (15%)
		KIF1B	<956..975	CDD:463574	2/3 (67%)
		DUF3694	1266..1422	CDD:463599
		PH_KIFIA_KIFIB	1710..1808	CDD:269939