Protein Alignment Klp61F and Kif1c

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_665884.2
• Gene: Kif1c / 113886
• RGDID: 70928
• Length: 1100
• Species: Rattus norvegicus
• Alignment Length: 1211
• Identity: 286/1211 - (23%)
• Similarity: 483/1211 - (39%)
• Gaps: 309/1211 - (25%)

  Fly    19 NIQVYVRVRPLNSRE-----RCIRSAE--VVDVVGPREVVTRHTLDSKLTKKFTFDRSF------ 70
            :::|.|||||.|:||     :|:.|.:  ...::.|::       .....|.||||.|:
  Rat     5 SVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQ-------SKDAPKSFTFDYSYWSHTSV 62

  Fly    71 -GPE-SKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGI 133
             .|: :.|..||..:...::.....|||..:|||||||.||::||:|.         ::....||
  Rat    63 EDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGR---------QEPGQQGI 118

  Fly   134 IPRALSHLFDELRM---MEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVI---I 192
            :|:....||..:.:   .::.|::.:||:|:|.|.:.|||:......:|:     ::..::   :
  Rat   119 VPQLCEDLFSRVNVNQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRV-----REHPILGPYV 178

  Fly   193 QGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENG-IEGEDMLKIGK 256
            |.|.::.|.|..|:..|::.|.:.|..|.|.||..|||||.||:||...|.:. :.|.|..|:.|
  Rat   179 QDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRSHDQLTGLDSEKVSK 243

  Fly   257 LNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD------RAPHVPYRESKLTR 315
            ::||||||||....:| .:|:|::|..|||:||.|||:||:||.|      ::..:|||:|.||.
  Rat   244 ISLVDLAGSERADSSG-ARGMRLKEGANINKSLTTLGKVISALADLQSKKRKSDFIPYRDSVLTW 307

  Fly   316 LLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEID 380
            ||:|:|||.::|::||.:||...:.|||||||.||.|.|.|:....:|:....: :::|..||:.
  Rat   308 LLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCNAVINEDPNAR-LIRELQEEVA 371

  Fly   381 KLKRDLMA----ARDKNGIYLAEETYGEITLKLES------------QNRELN-------EKMLL 422
            :|:..|||    |....|:.:.|.:.|.:.....|            .|.||.       |..:.
  Rat   372 RLRELLMAQGLSASALGGLKVEEGSPGGVLPAASSPPAPASPSSPPPHNGELEPSFSPSAEPQIG 436

  Fly   423 LKALKDELQNKEKIFSEVSMSLVE---KTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKE 484
            .:...:.||..|||.:|::.:..|   ||:.|:...|.||...|..:             :|...
  Rat   437 PEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMGVAV-------------REDGG 488

  Fly   485 LVA--SHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIR-------------RS 534
            .|.  |..||..::......:::...|     :.:...:.|..::|..|:             ||
  Rat   489 TVGVFSPKKTPHLVNLNEDPLMSECLL-----YHIKDGVTRVGQVDVDIKLTGQFIREQHCLFRS 548

  Fly   535 CDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQ- 598
            ..|....:...||...|                ::..||...|::.|.|.|...|.|.|....:
  Rat   549 IPQPDGEVMVTLEPCEG----------------AETYVNGKLVTEPLVLKSGNRIVMGKNHVFRF 597

  Fly   599 SLQDQTNLHNKL-----IGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRH 658
            :..:|..|..:.     .|...:..|.:   |..|  |.::||.:.:..|::..||.:|...::.
  Rat   598 NHPEQARLERERGVPPPPGPPSEPVDWN---FAQK--ELLEQQGIDIKLEMEKRLQDLENQYRKE 657

  Fly   659 KAMLDSMQEKFATII------DSSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERA 717
            |...|.:.|:.....      ||..:|.||..:.:....|||.          .|..:.:.....
  Rat   658 KEEADLLLEQQRLYADSDSGEDSDKRSCEESWRLISSLREQLP----------PNTVQTIVKRCG 712

  Fly   718 LAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEA 782
            |...........:.|:.|.:.|:.|:                .|...:.|:|  :|..:::..|.
  Rat   713 LPSSGKRRAPRRVYQIPQRRRLQGKD----------------PRWATMADLK--MQAVKEICYEV 759

  Fly   783 SQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEK-------------ETNENVG--- 831
            :.:......:::||             :..:.|:.|.:.|.|             :..:.||
  Rat   760 ALADFRHGRAEIEA-------------LAALKMRELCRTYGKPEGPGDAWRAVARDVWDTVGEEE 811

  Fly   832 -------------------SVRVHHNQVEIICQESK-------QQLEAVQEKTEVNLEQMVDARQ 870
                               .:|.|.:::..|.||.|       ::|:|::::. :.:|:::...|
  Rat   812 GCGGGGGGGEEGARGAEVEDLRAHIDKLTGILQEVKLQNSSKDRELQALRDRM-LRMERVIPLTQ 875

  Fly   871 QLITEDRQRFIGHATVA----TDLVQES----------------------NRQFSEHAEHQRQQL 909
            .|  ||.....|..|.|    ::.|:|:                      :|...|....:|.:|
  Rat   876 DL--EDDNEESGLVTWAPPEGSEAVEEAVSNDHSPAVRPSSPPQSSWERVSRLMEEDPAFRRGRL 938

  Fly   910 QICEQELVRFQQSELKTYAPTGTTPSKRDFVYPRTLVATSP------HQEIVRRYRQELDWSDLD 968
            :..:||.:|.|..:.......|.......||.|.......|      |:|         .|..:
  Rat   939 RWLKQEQLRLQGLQGSGGRGGGLRRPPARFVPPHDCKLRFPFKSNPQHRE---------SWPGM- 993

  Fly   969 TTATIDECSEGEHDVSMHSVQELSETETIMNSTPIEP----------VDGVTVKRGCGTT----- 1018
                    ..||.. .....:|::......|..|..|          :||.:..||.|:|
  Rat   994 --------GSGEAP-GPQPPEEVTAPPPPPNRRPPSPRRPHRPRRNSLDGGSRSRGGGSTQPEPQ 1049

  Fly  1019 ----RNSNSNALKP---PVATGGKRSSSLSRSLTPSKTSPR 1052
                :..||...:|   |....|.|       ..|..|.||
  Rat  1050 HLRPQKHNSYPQQPQPYPAQRPGPR-------YPPYTTPPR 1083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	133/373 (36%)
		SMC_prok_B	<408..728	CDD:274008	69/368 (19%)
		SMC_prok_B	<651..>921	CDD:274008	56/343 (16%)
		Microtub_bind	923..>1004	CDD:464048	13/86 (15%)
Kif1c	NP_665884.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	132/371 (36%)
		Kinesin_assoc	352..522	CDD:465047	37/188 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..435		6/36 (17%)
		FHA_KIF1C	498..599	CDD:438780	20/121 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	900..924		1/23 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	949..1100		31/161 (19%)