Protein Alignment Klp61F and KIF12

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_005251740.1
• Gene: KIF12 / 113220
• HGNCID: 21495
• Length: 669
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 158/531 - (29%)
• Similarity: 251/531 - (47%)
• Gaps: 114/531 - (21%)

  Fly    20 IQVYVRVRPLNSRE---------RC--IRSAEVVDVVGPREVVTRH--TLDSKLTKKFTFDRSFG 71
            |||.:||||:::.|         .|  .|:.:|....|..||..|.  .||:..|::..| |:.|
Human    26 IQVVLRVRPMSAAELRRGQQSVLHCSGTRTLQVSPPGGGPEVAFRFGAVLDAARTQEDVF-RACG 89

  Fly    72 PESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVG----NETAELKSSWEDDSDIG 132
                        |..|.|..|.|::||||.:||||:|||:|:.|    .|...:..|.     .|
Human    90 ------------VRRLGELALRGFSCTVFTFGQTGSGKTYTLTGPPPQGEGVPVPPSL-----AG 137

  Fly   133 IIPRALSHLFDELRMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEE 197
            |:.|..:.|.|.::.:....|:|.||||:|||::.||||......:.:..:.|:  ...::.|..
Human   138 IMQRTFAWLLDRVQHLGAPVTLRASYLEIYNEQVRDLLSLGSPRPLPVRWNKTR--GFYVEQLRV 200

  Fly   198 IPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIE------GEDMLKIGK 256
            :...|.:.:.:||:.|..||:.:...:|..|||||.:.::.:. |:...:      ||..:. ||
Human   201 VEFGSLEALMELLQTGLSRRRNSAHTLNQASSRSHALLTLYIS-RQTAQQMPSVDPGEPPVG-GK 263

  Fly   257 LNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD---RAPHVPYRESKLTRLLQ 318
            |..|||||||.|:..|: :|..:.|..:||:|||.||..|:.|:|   :..|:|:|:||||:||.
Human   264 LCFVDLAGSEKVAATGS-RGELMLEANSINRSLLALGHCISLLLDPQRKQSHIPFRDSKLTKLLA 327

  Fly   319 ESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLK 383
            :|||||..|.::|.:||..:.:.||||||.||.||:.:..:|:..:....|...:..||
Human   328 DSLGGRGVTLMVACVSPSAQCLPETLSTLRYASRAQRVTTRPQAPKSPVAKQPQRLETE------ 386

  Fly   384 RDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMSLVEKT 448
                                  .|:|:.:||.|..::       |::..|....|...::..::
Human   387 ----------------------MLQLQEENRRLQFQL-------DQMDCKASGLSGARVAWAQR- 421

  Fly   449 QELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLATDD 513
                       |..|.|   ::.:.:.:|..|||     |.::..:.|....|.|||
Human   422 -----------NLYGML---QEFMLENERLRKEK-----SQLQNSRDLAQNEQRILA-------- 459

  Fly   514 THQLHGTIERR 524
             .|:| .:|||
Human   460 -QQVH-ALERR 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	129/370 (35%)
		SMC_prok_B	<408..728	CDD:274008	25/117 (21%)
		SMC_prok_B	<651..>921	CDD:274008
		Microtub_bind	923..>1004	CDD:464048
KIF12	XP_005251740.1	KISc	25..363	CDD:276812	127/359 (35%)
		YhaN	<381..>472	CDD:443752	28/153 (18%)