Protein Alignment Klp61F and Kif22

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_006507264.1
• Gene: Kif22 / 110033
• MGIID: 109233
• Length: 690
• Species: Mus musculus
• Alignment Length: 721
• Identity: 203/721 - (28%)
• Similarity: 318/721 - (44%)
• Gaps: 172/721 - (23%)

  Fly     3 ISGGNTSRQPQKKSNQNIQVYVRVRPLNSRER------CIR-----SAEVVDVVGPREVVTRHTL 56
            :|.|...|:|..   ..::|.||:||....|.      |:|     |.||.:....:|
Mouse    25 VSKGGLGRRPPL---ARVRVAVRLRPFMDGETEAKELPCVRAIDSCSLEVANWKKYQE------- 79

  Fly    57 DSKLTKKFTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAEL 121
                |.|:.||..:|.:|.|.:||...|.|::..:|.|.|.:|.|||.||.||||||:|:
Mouse    80 ----TLKYQFDAFYGEKSTQQEVYVGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGS----- 135

  Fly   122 KSSWEDDSDIGIIPRALSHLFDELRMMEVE-----YTMRISYLELYNEELCDLLSTDDTTKIRIF 181
                  ....|:|||||..|....|....|     .::.:||||:|.|::.|||.......: |.
Mouse   136 ------PEQPGVIPRALMDLLQLAREESAEGRPWDVSVAMSYLEIYQEKVLDLLDPASGDLV-IR 193

  Fly   182 DDSTKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGI 246
            :|.  :|:::|.||.:.|:.|..|..:........|....|.:|.:|||||.|..:.|..||...
Mouse   194 EDC--RGNILIPGLTQKPITSFSDFEQHFLPASRNRAVGATRLNQRSSRSHAVLLVKVDQRERLT 256

  Fly   247 EGEDMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRES 311
            ....  :.|||.|:||||||:..:.||: |||::|:..||.||..||:|:.||....|.:|||:|
Mouse   257 PFRQ--REGKLYLIDLAGSEDNRRTGNQ-GIRLKESGAINTSLFVLGKVVDALNQGLPRIPYRDS 318

  Fly   312 KLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQ----------KL 366
            |||||||:||||...:.:||.|:|..:..::|:|.|.:..|:|.:.|:|..|:          ||
Mouse   319 KLTRLLQDSLGGSAHSILIANIAPERRFYQDTISALNFTARSKEVINRPFTNESLQPHALAPVKL 383

  Fly   367 TKKTVLKEYTEEIDKLKRDLMAARDKNGIYLAEETYG--EITLKLESQNRELNEKMLLLKALKDE 429
            ::|.:|.  ..|..|.|..            .||:.|  |.|....|.:::|        :|..:
Mouse   384 SQKELLG--PSEAKKAKGP------------EEESTGSPESTAAPASASQKL--------SLLQK 426

  Fly   430 LQNKEKIFSEVSMSLVEKTQELKKTEENLLNTKGT----LLLTKK----VLTKTKRRYKEKKELV 486
            |.|.:....|..:|:           |.||.::|:    ||.|.|    ||.||    .|:|.|.
Mouse   427 LSNMDPAMLENLLSM-----------ERLLGSQGSQGTPLLNTPKRERMVLMKT----VEEKNLE 476

  Fly   487 ASHMKTEQ------VLTTQAQEILAAADLAT--DDTHQLHGT---------------IERRRELD 528
            ...:|.:|      ||..:|.:.....:..|  .......||               |:::||..
Mouse   477 IERLKMKQKELEAKVLAQEAPDPREKENTPTILQPPASYSGTVAKPLKKAVVMPLQRIQKQRESS 541

  Fly   529 EKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKE------QLSQEMVNSSYVSQRLALNSSK 587
            .:|:......|.:::.:.|           .:|..|:      |:|.|:         ||....|
Mouse   542 NQIQLLKKGPKRKLEPSPE-----------SEAVEKDEDYWEVQISPEL---------LAHGRKK 586

  Fly   588 SIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVA--------KLMEQMQQQQLLMSKEI 644
            .:::|.|..|:.|:           .:.:|..:.:|..|.        ..:|.::|.:.:..|::
Mouse   587 LLDLLNEGSARELR-----------SLQRIGQKKAQLIVGWRELHGPFSEVEDLEQVEGISGKQV 640

  Fly   645 QTNLQV 650
            ::.|:|
Mouse   641 ESFLKV 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	131/373 (35%)
		SMC_prok_B	<408..728	CDD:274008	56/288 (19%)
		SMC_prok_B	<651..>921	CDD:274008	203/721 (28%)
		Microtub_bind	923..>1004	CDD:464048
Kif22	XP_006507264.1	KISc_KID_like	38..361	CDD:276827	127/350 (36%)
		ComEA	591..641	CDD:441164	10/60 (17%)