DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp61F and si:ch211-63b16.4

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	XP_009291330.1	Gene:	si:ch211-63b16.4 / 101882391	ZFINID:	ZDB-GENE-131121-480	Length:	853	Species:	Danio rerio

Alignment Length:	967	Identity:	225/967 - (23%)
Similarity:	365/967 - (37%)	Gaps:	254/967 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SNQNIQVYVRV--------RPLNSRERCIRSAE-------------VVDVVGPREVVTRHTLDSK 59
            |.::.:|.||:        ..:|..|.|:.:.|             |||.....:   ||.||
Zfish    10 SEKSFRVVVRLCARENTHSHTVNRAEHCVCTDEPRASIKVTHLNRLVVDTGRSHK---RHILD-- 69

  Fly    60 LTKKFTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVG-NETAELKS 123
                  ||.....|:.|.|||......|:|.::.|||..|..:|..|:||||||.| :.:|:.:
Zfish    70 ------FDDVLNEEASQRDVYESTTKSLVEYLMQGYNGCVIVFGSPGSGKTHTMQGCSVSAKHR- 127

  Fly   124 SWEDDSDIGIIPRALSHLFDELRMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKG 188
                    |||.||...:|:.......:  :|:|:..::||::.|||....:..|.:.|   .:.
Zfish   128 --------GIISRAAEDIFNSPNASHCK--IRVSFYHIFNEKIYDLLDPKGSEVIWVRD---CEE 179

  Fly   189 SVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLK 253
            .|.:.||.|:.|.|..::.::..:|...|.|..: .....:|:|.||:||| |.......|.:|.
Zfish   180 VVRLDGLTEVDVSSAHNLLQVHRRGSALRHTGIS-KGDFPNRTHMVFNIVV-INTMIQAPEGVLT 242

  Fly   254 IGKLNLVDLAGS--------ENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDR-APHVPYR 309
            ..||.|||||.|        .::.:..|.....::||..:.:||...|.||.||... :.|||||
Zfish   243 ASKLTLVDLASSGKCRASVVSDMKRTFNATNENLQETKMLKRSLTIFGNVIFALGSAGSQHVPYR 307

  Fly   310 ESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKE 374
            ||||||.|::.|||..:|.::.|:|.....:.||||:|::|.||..:.::|....:|       .
Zfish   308 ESKLTRALRDCLGGNCRTCLVVTVSSQSSSVSETLSSLQFASRAMAVPSRPLFLSQL-------H 365

  Fly   375 YTEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSE 439
            ||.|  ::...|...:|.|                     .||.:.:|.....|  :..:.....
Zfish   366 YTPE--QVCAYLNGKKDIN---------------------HLNRQQILPPVGFD--RRSQACLLP 405

  Fly   440 VSMSLVEKTQ------------ELKKTEENLLNTKGTLL--LTKKVLTKTKRRYKEKKELVASHM 490
            |.:|.|..|:            |||           |.|  |.|..........:.....|....
Zfish   406 VLLSSVSPTEPKLGLSHCADGPELK-----------TFLPQLEKPGQADPPGHNRRSSRPVDEIN 459

  Fly   491 KTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNL 555
            :|:..:|......|::|.|     |...|                   :||....||
Zfish   460 RTDGRMTRSLSRCLSSAVL-----HDTGG-------------------RDRTGKTLE-------- 492

  Fly   556 YQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQ 620
            :...|....|:||        :|....::|..::|.......:.::::   ::|:|.:..:..|.
Zfish   493 FSSAQRRSVERLS--------ISSLEPVSSPAAVECPNCTRERKIREE---YDKIIVQATRDKDS 546

  Fly   621 HSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAK 685
            .||. ||:|.::::::                |..:|.:||  |.::|         |..||.:.
Zfish   547 LSQK-VAELEDELRKR----------------ETQEREEAM--SWEKK---------QREEESSS 583

  Fly   686 QMHKKLEQLGAMSLPDAEELQNLQEELA----NERALAQQEDALLESMMMQMEQIKNLRSKNSIS 746
            ...:.........|....|...|:.||:    .||.|....|.|...:...:.||......||..
Zfish   584 STSEDQGIFQTAELCLQTEAAGLRAELSVCHERERVLNSDRDRLSRDVQDLLTQINCTTETNSQI 648

  Fly   747 MSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSML 811
            :|. ||...||.|..                     .::::.||....|:..:.|.|.....:.|
Zfish   649 VST-LNNQRESLLAE---------------------LRTSREELERFRESVSMTLSQLTTEKTEL 691

  Fly   812 QVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVDARQQLITED 876
            ...::..|..|||                  :|.|:    .|:::|.:..|.::..|
Zfish   692 MSRLEEANSSYEK------------------VCMEN----AALRQKLKSFLREINSA-------- 726

  Fly   877 RQRFIGHATVATDL--VQESNRQFSEHAEHQRQQL--------QICEQELVRFQQSE 923
              .|||.::..|:.  ...||.:....:.|..||.        :.|..:...||.||
Zfish   727 --PFIGSSSPDTNTPHTVTSNTEMIVVSHHVSQQCPAAGTKGSECCFSQDGGFQHSE 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	116/378 (31%)
		Kinesin	25..356	CDD:278646	113/361 (31%)
		Microtub_bind	923..>1009	CDD:290642	1/1 (100%)
si:ch211-63b16.4	XP_009291330.1	KISc	15..351	CDD:214526	113/362 (31%)
si:ch211-63b16.4	XP_009291330.1	Motor_domain	70..352	CDD:277568	100/297 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47970
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100