DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and Kif19b

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_001365608.1	Gene:	Kif19b / 101055939	MGIID:	3646257	Length:	974	Species:	Mus musculus

Alignment Length:	809	Identity:	223/809 - (27%)
Similarity:	373/809 - (46%)	Gaps:	174/809 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GGNTSRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVV-------TRHTLDSKLTK 62
            |..|.|:.:.| :|.:.|.:|:|||||.|....:..:...||.:.||       ...||.:..::
Mouse    14 GSPTLREMEPK-DQQLMVALRIRPLNSTELEEGATVIAHKVGDQVVVLMDPGEDPEDTLRAHRSR 77

  Fly    63 K--FTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSW 125
            :  |.||..|...:.|..||...:..|:|.|::|||.|:||||.:|.||||||:|
Mouse    78 ERTFIFDTVFDQHASQETVYCATIQHLVEGVISGYNTTIFAYGPSGAGKTHTMLG---------- 132

  Fly   126 EDDSDIGIIPRALSHLFDELRMME--VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKG 188
             .|::.||..:.|:.||..:...:  :||::.:||||:|||.:.|||: ..:..:.:.:||  :|
Mouse   133 -VDAEPGIYLQTLTDLFQAIEETQDNMEYSVSMSYLEIYNEVIRDLLN-PSSGFLELREDS--RG 193

  Fly   189 SVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLK 253
            |:.|.|:.|:...:..::.:||.||..:|....|..|..|||||.|..:.||.|..|.:..:.::
Mouse   194 SIQIAGITEVSTSNAQEIMQLLTKGNRQRTQEPTATNKTSSRSHAVLQVTVHQRSRGGDLAEEVR 258

  Fly   254 IGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD----RAPHVPYRESKLT 314
            :|:|.:|||||||..::..| :|.|::|..:||:|||.||..|.||.:    ||.:|.:|:||||
Mouse   259 LGRLFMVDLAGSERAAQTQN-RGKRMKEGAHINRSLLALGNCINALSEKGGSRAQYVNFRDSKLT 322

  Fly   315 RLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEI 379
            |||:::|||.::|.:||.|||.....||:.:||.||:|||||:.:.:.| .|.....:.:||:.|
Mouse   323 RLLKDALGGNSRTVMIAHISPASTSFEESRTTLLYAYRAKNIKTRVKRN-LLNVSYRIAQYTDVI 386

  Fly   380 DKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMSL 444
            ..|:|::                |.:..|:|.|::|
Mouse   387 SDLRREI----------------GHLKSKIEKQDKE----------------------------- 406

  Fly   445 VEKTQELKKTEENLLNTKGTL---------LLTKKVLTKTKRRYKEKKELVASHMKTE----QVL 496
                   ||::..:|:.:.|:         |...::..:....:||:.|:..|.::.|    ::.
Mouse   407 -------KKSDPGVLDIQVTIPHDAEEDSRLQMNRIRAQLIGAFKEQMEMRRSLVELENTNIELH 464

  Fly   497 TTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGS--------- 552
            ...::.:|..||...:.||| |..::           |.::.|:.:..:.|.:|.|
Mouse   465 IDMSRHLLTIADWEREKTHQ-HVDVD-----------SGERDKEPVDADGEEVGASEPPEVALAR 517

  Fly   553 --LNLY---QDQQAALKEQLSQEMVNSSYVSQRL------ALNSSKSIEMLKEMC-AQSLQ-DQT 604
              :||.   |.:.||||..|.|.:.::...:.::      .:.|.:..|:|:.:| |..|: :.|
Mouse   518 EEVNLLLAEQQKTAALKAGLEQRLAHAKQKASQMEKLLPRQVTSEEQREVLQLLCRAHELEVENT 582

  Fly   605 NLHNKLIGEVMKISDQHSQAFVAKLM-------EQMQQQQLLMSKEIQTNLQVIEENNQRHKAML 662
            .|             |....|...|:       ::..|.:||..:.||...|::::|.......|
Mouse   583 EL-------------QADNLFRKNLLCQKDFVIQRYHQHRLLCEQVIQGQRQLMQDNGISAPEPL 634

  Fly   663 DSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSL------------PDAEELQNLQEELANE 715
            :....         |.|.|.....:.:.|.||..||.            |..||...  |.|.:.
Mouse   635 EQQYR---------LYSRELGEGTLDRLLLQLSVMSSSLQDGPIMNVSPPPTEESSG--EPLGDR 688

  Fly   716 RALAQQEDALLESMMMQMEQIKNLRSKNS 744
            |.|.......|..|:::.:...|..||::
Mouse   689 RDLPWGATFELPQMLLERDSDGNRSSKST 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	138/362 (38%)
		Kinesin	25..356	CDD:278646	133/345 (39%)
		Microtub_bind	923..>1009	CDD:290642
Kif19b	NP_001365608.1	KISc_KIP3_like	27..364	CDD:276821	134/351 (38%)
Kif19b	NP_001365608.1	PHA03307	675..>974	CDD:223039	12/45 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910