Protein Alignment Klp61F and kif5c

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_002935337.3
• Gene: kif5c / 100493873
• XenbaseID: XB-GENE-977474
• Length: 959
• Species: Xenopus tropicalis
• Alignment Length: 1014
• Identity: 272/1014 - (26%)
• Similarity: 452/1014 - (44%)
• Gaps: 188/1014 - (18%)

  Fly    19 NIQVYVRVRPLNSRE--------RCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESK 75
            :|:|..|.||||..|        ...:..:.| ||||             :|.:.||:.|...:.
 Frog     8 SIKVMCRFRPLNKAEIQRGDKFIPVFKGEDTV-VVGP-------------SKPYVFDKVFPSNTT 58

  Fly    76 QCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSH 140
            |..|||.....::::||:|||.|:||||||.:||||||.|        ...|...:|||||....
 Frog    59 QEHVYSACAKQIVKDVLDGYNGTIFAYGQTSSGKTHTMEG--------KLHDHQMMGIIPRIAHD 115

  Fly   141 LFDELRMME--VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSK 203
            :||.:..|:  :|:.:::||.|:|.:::.|||   |.:|..:.....|.....::|..|..|.|.
 Frog   116 IFDHIYSMDENLEFHIKVSYFEIYLDKIRDLL---DVSKTNLAVHEDKNRVPFVKGCTERFVSSP 177

  Fly   204 DDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENV 268
            ::|..::::||..|..|.|.||..|||||::|  :::|::..:|.|..|. |||.||||||||.|
 Frog   178 EEVMDVIDEGKANRHVAVTNMNEHSSRSHSIF--LINIKQENVETEKKLS-GKLYLVDLAGSEKV 239

  Fly   269 SKAGNEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESLGGRTKTSIIAT 332
            ||.|.| |..:.|..|||:||..||.||:||.: ...|||||:||:||:||:||||..:|:||..
 Frog   240 SKTGAE-GAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIIIC 303

  Fly   333 ISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDK----------LKRDLM 387
            .||...:..||.|||.:..|||.|:|...||.:||.:...|:|.:|.||          |:.:|.
 Frog   304 CSPSIFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKDKTKSLKNIIQHLEMELN 368

  Fly   388 AARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMSLVEKTQELK 452
            ..|....:.:.|:|..:....||..:.        ...:.:.|.....|.||          |.|
 Frog   369 RWRRGEAVPVDEQTSAKDQKTLEPCDN--------TPVIDNGLVGATNISSE----------EKK 415

  Fly   453 KTEENLLNTKGTL-------LLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLA 510
            |.:|::.:..|.|       ....:::.|.|::..:::||:||..:..:.:..:...:....|.|
 Frog   416 KYDEDIASLYGQLDDKDDEINQQSQLIEKLKQQMLDQEELLASTRRDYEKIQEELTRLQIENDAA 480

  Fly   511 TDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSS 575
            .|:..::...:       |::..:.||....::|               :..|.||||:|:...:
 Frog   481 KDEVKEVLQAL-------EELAVNYDQKSQEVED---------------KTKLNEQLSEELTQKT 523

  Fly   576 ---YVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKL------IGEVMKISDQHSQAFV-AKLM 630
               .|:||       .:..|:|:.....:..|.:.|.|      ||.::..:|..:.|.| ..:.
 Frog   524 TNLTVTQR-------ELSQLQELSNHQRKRTTEILNLLLKDLGEIGGIVGTNDVKTLAEVNGVIE 581

  Fly   631 EQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLG 695
            |:....:|.:||.......::..:.|...|.:::.::..|:  :..|.:.:..:.|...|::.|
 Frog   582 EEFTMARLYISKMKSEVKSLVNRSKQLESAQIEANRKINAS--EKELAACQLLSSQHEAKIKSL- 643

  Fly   696 AMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKMEESRLT 760
                  .:.:||:::   ..|.|.:.:|||       .|::..|.::..:. .|.....|:..||
 Frog   644 ------TDYMQNMEQ---RRRQLEEAQDAL-------NEELARLHAQEKMH-KVSFQDKEKEHLT 691

  Fly   761 RNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEKE 825
            |....::||..::...:...||.|...:.|..::|.....:|........||:.:..|...|||
 Frog   692 RLQDAEEIKKTLEQQMESHREAHQKQLSRLRDEIEEKQKMIDDLKDLNQKLQLQLDKLTSDYEK- 755

  Fly   826 TNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVN------LEQMVDARQQLITEDRQRFIGHA 884
                   ::....|.|    |..|:|..:.||.|.:      ||:.|....|.:...|:.||...
 Frog   756 -------LKTEEEQRE----EDLQKLVLLNEKREQSREDLKGLEETVARELQTLHNLRKLFIQDL 809

  Fly   885 TVATDLVQE----------SNRQFSEHAEHQRQQLQICEQELVRFQQSELKTYAPTGTTPSKRDF 939
            .:......|          :.:|.....|:..:||....::||| ..::|:...|.
 Frog   810 ALRVQKRVELDSDNGGGSAAQKQKISFLENNLEQLTKVHKQLVR-DNADLRCELPK--------- 864

  Fly   940 VYPRTLVATSPHQEIV---------------RRYRQELD 963
             ..:.|.||:...:.:               |||:||:|
 Frog   865 -LEKRLRATAERVKALEGALKEAKENAMRDRRRYQQEVD 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	143/356 (40%)
		SMC_prok_B	<408..728	CDD:274008	62/336 (18%)
		SMC_prok_B	<651..>921	CDD:274008	58/285 (20%)
		Microtub_bind	923..>1004	CDD:464048	11/56 (20%)
kif5c	XP_002935337.3	KISc_KHC_KIF5	6..327	CDD:276820	139/347 (40%)
		EnvC	452..>676	CDD:443969	50/271 (18%)
		SMC_prok_B	580..>912	CDD:274008	73/366 (20%)
		Khc_CBD_cc	836..905	CDD:467880	17/78 (22%)