Protein Alignment Klp61F and kif13b

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_031758942.1
• Gene: kif13b / 100492799
• XenbaseID: XB-GENE-956968
• Length: 1943
• Species: Xenopus tropicalis
• Alignment Length: 1201
• Identity: 282/1201 - (23%)
• Similarity: 493/1201 - (41%)
• Gaps: 325/1201 - (27%)

  Fly    16 SNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLT--------KKFTFDRSFGP 72
            |:..::|.||:||:|.||..:::..||||...:.|:  :..::.|:        |.|.:|..|..
 Frog     2 SDSTVKVAVRIRPMNRREVDLQTKCVVDVENNQIVL--YPSNASLSKGDARSQPKVFAYDHCFWS 64

  Fly    73 ESK--------QCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDS 129
            ..:        |..|:..:...:::....|||..:|||||||:||::||:|  ||:
 Frog    65 MDESVKEKFAGQDVVFQCLGENILQNAFEGYNACIFAYGQTGSGKSYTMMG--TAD--------- 118

  Fly   130 DIGIIPRALSHLFDELRMMEVE---YTMRISYLELYNEELCDLL---STDDTTKIRIFDDSTKKG 188
            ..|:|||..|.||:..:..|.|   :.:.:|::|:|||::.|||   .:..:.|:|    ..|..
 Frog   119 QPGLIPRLCSTLFERTQKAENEELSFKVEVSFMEIYNEKVRDLLDPKGSRQSLKVR----EHKVL 179

  Fly   189 SVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVV-HIR---ENGIEGE 249
            ...:.||.::.|.|..|:..|:.:|.:.|..|.|.||.:|||||.||:|:: |..   ::|..||
 Frog   180 GPYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIILTHTLVDVKSGTSGE 244

  Fly   250 DMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRA------PHVPY 308
               |:.||:||||||||..:|.| ..|.|::|..|||:||.|||.||:||.|:.      ..|||
 Frog   245 ---KVSKLSLVDLAGSERATKTG-AAGERLKEGSNINKSLTTLGLVISALADQGAGKNKNKFVPY 305

  Fly   309 RESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLK 373
            |:|.||.||::||||.:||:::||:||...:.:||||||.||.|||||.|...||:....: :::
 Frog   306 RDSVLTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKNIVNHAVVNEDPNAR-IIR 369

  Fly   374 EYTEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKA--LKDELQNKEKI 436
            |..||::||:..|..|..                               :||  ||:.||..||:
 Frog   370 ELREEVEKLRVQLTQAES-------------------------------MKAPELKERLQESEKL 403

  Fly   437 FSEVSMSLVEK---TQELKKTEENLLNTKGTLLLTKKV-----------------LTKTKRRYKE 481
            ..|::::..||   |:::.:..:..|.:.|..|.:..:                 |.:....|.:
 Frog   404 IQEMTVTWEEKLRMTEDIAQERQKQLESLGISLQSSGIKVGDNKSFLVNLNADPALNELLVYYLK 468

  Fly   482 KKELVASHMKTEQVL--------------TTQAQEILAAADLATDDTHQLHGTIERRRELDEKIR 532
            ...|:.||...:..|              :.:.|.||  ..:....|:.....:.:..:|
 Frog   469 DHTLIGSHDSQDIQLCGLGILPEHCIIDISPEGQVIL--TPMKNTRTYVNGSAVTKATQL----- 526

  Fly   533 RSCDQFKDRMQDNLEMIGGS----LNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLK 593
                |..||:     :.|.:    ::|.:.::|..:::.....:.:|...::|.|:...|.|...
 Frog   527 ----QHGDRI-----LWGNNHFFRISLPKKKKAKQEDEEQDSSLRNSSSFEQLDLDGDSSSEGSS 582

  Fly   594 EMCAQSLQDQTNLHNKLIGE-------VMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVI 651
            |:.......|..:..|.:|.       :..:..||.:    :....:::|:|:...|:....:.:
 Frog   583 EVNFNYEYAQMEIMMKALGNNDPMQSILQSLEQQHEE----EKRSALERQRLMYEHELDQLRRRL 643

  Fly   652 EENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANER 716
            ....|.:::|     ::|:....::.|.:.:..::....|.|          .|:.|:|::|...
 Frog   644 SPEKQHYRSM-----DRFSFGSPNAQQRIRQWTEEREAMLNQ----------SLRKLREQIAKAN 693

  Fly   717 ALAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKMEESRLTR-------------------- 761
            ...|:.:.:.|.|..:.|....|:...|   |::.||...:.|:.
 Frog   694 LHVQEANFIAEEMDKRTEYKVTLQIPAS---SLNANKKRGAVLSEPAIQVRRKGKGKQIWSLEKL 755

  Fly   762 NHRIDDIKSGIQDYQKLG----IEASQSAQAE-LTSQMEAGMLCLDQGVANCSM--------LQV 813
            .:|:.||:...|::::..    :..|...:|: ...:.|...|.   ||||..:        ||.
 Frog   756 ENRLVDIRDLYQEWKECDEDDPMSRSYFRRADPFYDEHENHSLI---GVANVFLESLFHDVKLQY 817

  Fly   814 HMKNLNQK--------------------------------YEKETNEN--VGSVRV-------HH 837
            .:..:|||                                :|||..||  |..::|       .|
 Frog   818 AVPIINQKGEVAGRLHVEVVRISGDIEDRIAGGEDGADFSFEKEAQENKLVCMIKVLQATGLPQH 882

  Fly   838 NQVEIICQE-SKQQLEAVQEKTEVN--------LEQMV--DARQQL---ITEDRQRFIGHATVAT 888
            ....:.|.. ...|.|......||:        .|.||  |..::.   ||||...::....:|.
 Frog   883 LTNFVFCHYIFWDQPEPTTVAPEVDTAPPVIKGTECMVVFDHCKEFVVNITEDFLEYLSEGALAI 947

  Fly   889 D-------------------LVQESNRQFSEHAEHQRQQLQICEQELVRFQQSELKTYAPTGTTP 934
            :                   ::|...|...:......:::::..|.|   :.:|...|.|...||
 Frog   948 EVYGHRQSDPHRNPALWDLGIIQAKTRSLRDRWSEVTRKVELWVQIL---ELNENGEYCPVEVTP 1009

  Fly   935 SKRDFVYPRTLVATSPHQEIVRRYRQELDWSDLDTTATIDECSEGEH---DVSMHSVQELSETET 996
            :|                             |:. |..|.:..:|:.   .:...|||:......
 Frog  1010 AK-----------------------------DVQ-TGGIYQLKQGQSRRLHIEARSVQDSGTLPL 1044

  Fly   997 IMNSTPIEPVDGVTVKRGCGTTRNSNSNALK 1027
            |.:|.       :::..||  .:..|:.|:|
 Frog  1045 IEDSI-------LSISIGC--VKIVNAKAIK 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	145/379 (38%)
		SMC_prok_B	<408..728	CDD:274008	57/366 (16%)
		SMC_prok_B	<651..>921	CDD:274008	63/376 (17%)
		Microtub_bind	923..>1004	CDD:464048	15/83 (18%)
kif13b	XP_031758942.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	143/376 (38%)
		Kinesin_assoc	357..469	CDD:465047	26/143 (18%)
		FHA_KIF13B	447..545	CDD:438782	15/113 (13%)
		DUF3584	<589..>867	CDD:432349	50/302 (17%)
		KIF1B	755..801	CDD:463574	8/48 (17%)
		DUF3694	1001..>1055	CDD:463599	14/90 (16%)
		bMERB_dom	<1097..1141	CDD:463467
		DUF3694	<1185..1276	CDD:463599
		CAP_GLY	1810..1873	CDD:460154