Protein Alignment Klp61F and kif13a

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_002932725.3
• Gene: kif13a / 100490129
• XenbaseID: XB-GENE-1010803
• Length: 1967
• Species: Xenopus tropicalis
• Alignment Length: 1192
• Identity: 283/1192 - (23%)
• Similarity: 484/1192 - (40%)
• Gaps: 315/1192 - (26%)

  Fly    16 SNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKL------TKKFTFDRSF---- 70
            |...:.|.|||||:|.||..:.:..||::.|.:.::.....::|.      .|.|.||..|
 Frog     2 SASKVLVAVRVRPMNRRELDLNTKCVVEMEGNQTILQTPPANAKQGESRKPPKVFAFDYCFWSMD 66

  Fly    71 --------GPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWED 127
                    |.|:    |:..:...:::....|||..:|||||||:||:.:|:|  ||:
 Frog    67 ESNTPKYAGQEA----VFKCLGEGILDNAFQGYNACIFAYGQTGSGKSFSMMG--TAD------- 118

  Fly   128 DSDIGIIPRALSHLFDELRMMEVE-----YTMRISYLELYNEELCDLL---STDDTTKIRIFDDS 184
              ..|:|||....||.  |..|.|     :.:.:||:|:|||::.|||   ....:.|:|    .
 Frog   119 --QPGLIPRLCCALFQ--RASEEESDSQSFKVEVSYMEIYNEKVRDLLDPKGNRHSLKVR----E 175

  Fly   185 TKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVV----HIRENG 245
            .|.....:.||.::.|.:.:|:..|:.:|.:.|..|.|.||.:|||||.||||:|    :..::|
 Frog   176 HKVLGPYVDGLSQLAVTNFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFSIIVTQTLYDHQSG 240

  Fly   246 IEGEDMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRA------P 304
            ..||   ::.|::||||||||.|||.| ..|.|::|..|||:||.|||.||::|.|:|      .
 Frog   241 NSGE---RVSKVSLVDLAGSERVSKTG-AAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKNK 301

  Fly   305 HVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKK 369
            .||||:|.||.||:::|||.:||::||||||...:.|||||||.||.|||.|.|...||:....:
 Frog   302 FVPYRDSVLTWLLKDNLGGNSKTAMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAR 366

  Fly   370 TVLKEYTEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKA--LKDELQN 432
             |::|..||::|||..|..|..                               :||  ||::|:.
 Frog   367 -VIRELREEVEKLKEQLSQAES-------------------------------MKAPELKEKLEE 399

  Fly   433 KEKIFSEVSMSLVE---KTQELKKTEENLLNTKGTLLLTKKVLTKTKRRY-------KEKKELVA 487
            .||:..|::::..|   ||:|:.:..:..|.:.|..|.:..:.....:.|       ....||:.
 Frog   400 SEKLIRELTITWEEKLRKTEEIAQGRQRQLESMGISLESSGIKVGDDKCYLVNLNADPALNELLV 464

  Fly   488 SHMKTE-----------QVLTTQAQEILAAADLATD-DTHQL---------HGTIERRRELDEKI 531
            .::|..           |:.....|:......:|:| ||:.:         :||:
 Frog   465 YYLKGHNRIGADTSQDIQLFGIGIQQEHCVIHVASDGDTYLIPKENARTCVNGTL---------- 519

  Fly   532 RRSCDQF---------------------KDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSS 575
              .|:|.                     |.:.:|.|:.........:....|..|..|:...|..
 Frog   520 --VCEQTPLWHGDRILWGNNHYFRLNLPKRKRKDWLKEFEKEAGCSETDLDAASEASSEPDYNYE 582

  Fly   576 YVSQRL---ALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQ 637
            :....:   ||||:..:                 ||     |:::.::.   ::.:....:::|:
 Frog   583 FAQMEVIMKALNSNDPV-----------------HN-----VVQVLEKQ---YLEEKRTALEEQR 622

  Fly   638 LLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDA 702
            |:..:|::         ..||:...|...:.....:....|:.::......::.::|...|
 Frog   623 LMYERELE---------QLRHQLSPDRHHQHSTERLSYGSQTAQQKMNMWAEERDELFRQS---- 674

  Fly   703 EELQNLQEELANERALAQQEDALLESM--------MMQMEQIKNL---RSKNSISMSVHLNKMEE 756
              |..|:|::.....|.::.:.|.|.|        .:|:..: ||   |.:.:|.....:.....
 Frog   675 --LSKLREQIVKANTLVREANFLAEEMNKCTDYQVTLQIPAV-NLSANRKRGAIVSEPAIQVRRR 736

  Fly   757 SRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQ-------GVANCSM---- 810
            .|.|:...|:.:::.:.|.:....|..:..|.......:.|....:.       ||||..:
 Frog   737 CRGTQIWTIEKLENKLIDMRDAYQEWKEKPQENKRVSYKKGNPFYEAQENHNLIGVANVFLECLF 801

  Fly   811 ----LQVHMKNLNQKYE-------------------------KETNENVGSVRVHHNQVEIICQE 846
                ||..:..::|:.|                         .|.:...||..:..|..|||.:.
 Frog   802 YDVKLQYAVPIISQQGEVAGRLHVEVMRVTGVVPECLVGDDSSENSSESGSFDIIDNSGEIIHRT 866

  Fly   847 SKQQLEA-VQEKT--EVNLEQMVDAR----QQLITEDRQRFIGHATVATDLV-------QESNRQ 897
            .|..... ::|.|  .:||...|..:    .||          ..|||..:|       :..:.|
 Frog   867 KKLTCRVKIKEATGLPLNLSNFVFCQYTFWDQL----------EPTVAPPMVNPDMPSPRSKDVQ 921

  Fly   898 FSEHAEHQRQQLQICEQELVRF-QQSEL------KTYAPTGTTPSKRDFVYPRTLVATSPHQEIV 955
            |:....|.:..:....:|.:.| .:..|      ...|..|.:..:.|.::.::........|:.
 Frog   922 FTVKFAHAKDYVVHITEEFLEFISEGALAIEVWGHRCAGNGRSLWEIDSLHAKSRTLRDRWSEVT 986

  Fly   956 RRYRQELDWSDLDTTATIDECSE-GEH---------DVSMHSVQELSETETIMNSTPIEPVDG-- 1008
            ||         ::|..:|.|.:| |::         |||...|.:|.:..:......::|:..
 Frog   987 RR---------IETWISIYELNENGDYTSVELHQAKDVSTGGVFQLRQGHSRRIQVTVKPMQNSG 1042

  Fly  1009 ---------VTVKRGCGTTRNS 1021
                     ::|..||.|.|::
 Frog  1043 TLPLMVEAILSVSVGCITARST 1064

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	147/383 (38%)
		SMC_prok_B	<408..728	CDD:274008	57/376 (15%)
		SMC_prok_B	<651..>921	CDD:274008	57/335 (17%)
		Microtub_bind	923..>1004	CDD:464048	17/96 (18%)
kif13a	XP_002932725.3	KISc_KIF1A_KIF1B	4..360	CDD:276816	145/380 (38%)
		Kinesin_assoc	357..468	CDD:465047	29/142 (20%)
		FHA_KIF13A	447..555	CDD:438781	17/119 (14%)
		SMC_prok_B	<553..>765	CDD:274008	38/252 (15%)
		KIF1B	748..792	CDD:463574	4/43 (9%)
		bMERB_dom	<1102..1146	CDD:463467
		DUF3694	<1224..1279	CDD:463599
		CAP_GLY	1836..1900	CDD:460154