DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and kif13bb

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	XP_009299747.1	Gene:	kif13bb / 100317281	ZFINID:	ZDB-GENE-090908-5	Length:	2095	Species:	Danio rerio

Alignment Length:	1197	Identity:	283/1197 - (23%)
Similarity:	476/1197 - (39%)	Gaps:	349/1197 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVV--TRHTL---DSKLTKK-FTFDRSF---- 70
            :..|::|.|||||:|.|||.:::..||::.|.:.::  ....|   ||:...| |.:|..|
Zfish     8 NESNVKVAVRVRPMNRRERDLKTKCVVEMEGNQTILYPASGNLGKGDSRAKPKCFAYDYCFWSMD 72

  Fly    71 ----GPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDI 131
                |..:.|..|:..:...|::....|||..:|||||||:||::||:|:           ....
Zfish    73 EAETGKFAGQDVVFQCLGESLLDSAFQGYNACIFAYGQTGSGKSYTMMGS-----------SEQP 126

  Fly   132 GIIPRALSHLFDE--LRMMEVE-YTMRISYLELYNEELCDLL---STDDTTKIRIFDDSTKKGSV 190
            |:|||..|.||:.  |...|.| :|:.:||:|:|||::.|||   .:....|:|       :.:|
Zfish   127 GLIPRLCSSLFERSVLEQREGESFTVEVSYMEIYNEKVRDLLDPKGSRQALKVR-------EHNV 184

  Fly   191 I---IQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVV-H-IRE--NGIEG 248
            :   :.||..:.|.|..|:..|:.:|.:.|..|.|.||.:|||||.||:|:: | :|:  .|..|
Zfish   185 LGPYVDGLSRLAVSSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIILTHTLRDMKTGTSG 249

  Fly   249 EDMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD------RAPHVP 307
            |   |:.||:||||||||...|.| ..|.|::|..|||:||.|||.||:||.:      ::..||
Zfish   250 E---KVSKLSLVDLAGSERADKTG-AAGERLKEGSNINRSLTTLGLVISALAEQGAGKNKSKFVP 310

  Fly   308 YRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVL 372
            ||:|.||.||::||||.::|:::|.:||...:.|||||||.||.|||:|.|...||:....: ::
Zfish   311 YRDSVLTWLLKDSLGGNSRTAMVAAVSPAADNYEETLSTLRYADRAKSIINHAVVNEDPNAR-II 374

  Fly   373 KEYTEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKA--LKDELQNKEK 435
            :|..||::||:..|..|..                               :||  ||:.|:..||
Zfish   375 RELREEVEKLRSQLSEAES-------------------------------MKAPELKERLEESEK 408

  Fly   436 IFSEVSMSLVEK-------TQELKKTEENL---LNTKGTLLLTKKVLTKTKRRYKEKKELVASHM 490
            :..|:::|..||       .||.:|..|:|   |.:.|..::.:|.............||:..::
Zfish   409 LIQEMTVSWEEKLRKTEEIAQERQKQLESLGISLQSSGIRVIDEKCFLVNLNADPALNELLVYYL 473

  Fly   491 KTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRE-----LDEKIRRSCDQFKDRMQDNLEMIG 550
            |....:.:...:.:....||....|.:   |:.:.|     ..::..|:|
Zfish   474 KEHTRVGSADSQDIQLCGLAIQPEHCI---IDIKPETGVTLTPKRNARTC--------------- 520

  Fly   551 GSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVM 615
                                 ||.:.||..:.|:....|          |....:.....:..|.
Zfish   521 ---------------------VNGAVVSSAIQLHHGDRI----------LWGNNHFFRISVSNVY 554

  Fly   616 KISDQHSQAFVAKLME-------------------QMQQQQLLM-----SKEIQTNLQVIEENN- 655
            ::.|:......|.|..                   :..|.:::|     :..:|:.|..:|..:
Zfish   555 RVEDEDGCVMKAGLRSDHLDVDRLSLASSDTSFSFESAQTEVMMKALGNNDPMQSVLHSLERRHE 619

  Fly   656 -------QRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPD------------ 701
                   :|.:.|.:...::....:.|.||:...| .|.|:..|||.|.:|..
Zfish   620 EEKRSALERQRLMYEQELQQLRKRLSSELQTQSSH-PQHHRSSEQLNASALSSQSRLRQWTDDRE 683

  Fly   702 ---AEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSV-----HLNKMEESR 758
               :..|:.|:|::.....|.|:...:.|.:        |.:::..:::.:     :.|:..::.
Zfish   684 VLMSRSLRKLREQIVKANLLVQEAGFIAEDL--------NKKTEYKVTLQIPAANLNANRKRDTV 740

  Fly   759 LTR--------------------NHRIDDIKSGIQDYQKLGIE--ASQS----AQAELTSQMEAG 797
            |:.                    .:|:.|::...|:::....:  |.:|    |......|....
Zfish   741 LSEPAIEVRRKGKGKQIWALEKIENRLVDMRDLYQEWKDYDEDDPAMRSYFKRADPFFDEQENHS 805

  Fly   798 MLCLDQGVAN----CSMLQVHMKN----LNQKYE----------------KETNENVGSVRVHHN 838
            ::    ||||    |.:.:|.::.    :|||.|                :|:..:.|.   ..|
Zfish   806 LI----GVANVFLSCLLYEVKLQYAVPIINQKGEVSGRLHVEVERLSGGLEESETDTGD---SEN 863

  Fly   839 QVEIICQESK----------------------------QQLEAVQEKTEVNLEQMVDARQQ---- 871
            ..|...||.|                            .|.|.|....||.|........|
Zfish   864 SPESEMQERKFTCMIKVLQATGLPQHLSNFVFCQYHFWDQPEPVFIAPEVGLSAASSREPQSLVV 928

  Fly   872 ---------LITEDRQRFIGHATVATD-------------------LVQESNRQFSEHAEHQRQQ 908
                     .:|||.|.|:....||.:                   ::|...|...|......::
Zfish   929 FDNCKTLEVAVTEDFQEFLMEGAVAVEVYGHKQENPRRNLALWDLGVIQAKTRSLRERWSEVTRR 993

  Fly   909 LQICEQELVRFQQSELKTYAPTGTTPSKRDFVYPRTLVATSP----HQEIVRRYRQELDWSDLDT 969
            |::..|.|   :.::...:.|....|:|.        |.|..    .|...||...|:  ..:..
Zfish   994 LELWVQVL---EINDTGVFVPVEVQPAKD--------VCTGGIFQLKQGQSRRVHVEV--RSVQD 1045

  Fly   970 TATIDECSEGEHDVSMHSVQELSETET 996
            :.|:...:|....:||.:| |:.:..|
Zfish  1046 SGTLPLIAESVLSISMGNV-EVQQART 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	149/380 (39%)
		Kinesin	25..356	CDD:278646	142/363 (39%)
		Microtub_bind	923..>1009	CDD:290642	16/78 (21%)
kif13bb	XP_009299747.1	KISc_KIF1A_KIF1B	10..366	CDD:276816	147/377 (39%)
		KISc	11..366	CDD:214526	147/376 (39%)
		Kinesin_assoc	363..475	CDD:292801	30/143 (21%)
		FHA	453..550	CDD:238017	18/145 (12%)
		KIF1B	764..809	CDD:289208	7/48 (15%)
		DUF3694	<1224..1282	CDD:289256
		CAP_GLY	1983..2046	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910