DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp61F and kif3a

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	XP_017947685.1	Gene:	kif3a / 100145686	XenbaseID:	XB-GENE-986464	Length:	766	Species:	Xenopus tropicalis

Alignment Length:	769	Identity:	244/769 - (31%)
Similarity:	399/769 - (51%)	Gaps:	121/769 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ISGGNTSRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDS--KLTKKFT 65
            |||.|.:.:|:  |..|::|.||.||||.|||.:.|...|.|...|..:|.|.:||  :..|.||
Frog    67 ISGINRADKPE--SCDNVKVVVRCRPLNERERAMNSKMAVGVDEMRGTITVHKVDSMNEPPKTFT 129

  Fly    66 FDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVG-NETAELKSSWEDDS 129
            ||..|||:|.|.|||::...|:|:.||.|||.|:|||||||||||.||.| ....||:
Frog   130 FDTVFGPDSNQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPELR------- 187

  Fly   130 DIGIIPRALSHLFDELRMME--VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVII 192
              ||||.:.:|:|..:...|  ..:.:|:||||:||||:.|||..|.:.::.:  .......|.|
Frog   188 --GIIPNSFAHVFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQSQRLEV--KERPDVGVYI 248

  Fly   193 QGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKL 257
            :.|....|::.||:.:::..|.:.|....|.||..|||||.:|:|.:...|.|.:|...:::|||
Frog   249 KDLSGYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGADGNIHVRMGKL 313

  Fly   258 NLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESL 321
            :||||||||..:|.| ..|.|::|...||.||.|||.||:|||| ::.|||||.||||||||:||
Frog   314 HLVDLAGSERQAKTG-ATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSL 377

  Fly   322 GGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDL 386
            ||.:||.:.|.|.|...:.:||:|||.||:|||||:||..:|:. .|..:|:::.:||:.||:.|
Frog   378 GGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINED-PKDALLRQFQKEIEDLKKKL 441

  Fly   387 MAARDKNGI-------------YLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFS 438
            ....|.:|.             .:.|:  ||...|...:.:...:||..::|..||  .::.:.:
Frog   442 EEGEDVSGSDDSGTEDDDDEDGEIGED--GEKKKKRRGKKKGSPDKMAEMQARIDE--ERKALEA 502

  Fly   439 EVSMSLVEKTQ---ELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQA 500
            ::.|...|:.:   ||::.|::|                    :|.::|   .|...|::...:.
Frog   503 KLDMEEEERNKARAELERREKDL--------------------FKAQQE---HHSLLEKLSALEK 544

  Fly   501 QEILAAADL---ATDDTHQLHGT---IERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQ 559
            :.|:...||   |.:....|..:   :|.||:..||:||   :.:::.|:.|::        :::
Frog   545 KVIVGGVDLLAKAEEQERLLEESNFELEERRKRAEKLRR---ELEEKEQERLDI--------EEK 598

  Fly   560 QAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQA 624
            ..:|:|:               |...:|.::.:..|...:..:..:|            .|..|.
Frog   599 YTSLQEE---------------AQGKTKKLKKVWTMLMAAKSEMADL------------QQEHQR 636

  Fly   625 FVAKLMEQMQQQQLLMSKEIQTNLQVIEE-NNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMH 688
            .:..|:|.::|    :|:|::..:.:|:. ..|.::.|:::.......|.:..|:.|......|.
Frog   637 EIEGLLENIRQ----LSRELRLQMNIIDSFIPQEYQEMIENYVHWNEDIGEWQLKCVAYTGNNMR 697

  Fly   689 KKLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSK 742
            |:      ..:||.:|....:.:|::. .||..|::|.:| :|::|:.:..:.|
Frog   698 KQ------TPVPDKKEKDPFEVDLSHV-YLAYTEESLRQS-LMKLERPRTSKGK 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	163/353 (46%)
		Kinesin	25..356	CDD:278646	155/336 (46%)
		Microtub_bind	923..>1009	CDD:290642
kif3a	XP_017947685.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030