DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment galene and Kcnk10

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001303594.1	Gene:	Kcnk10 / 72258	MGIID:	1919508	Length:	538	Species:	Mus musculus

Alignment Length:	170	Identity:	52/170 - (30%)
Similarity:	79/170 - (46%)	Gaps:	36/170 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 WKVLTCIVSHVLLVLLVVSYCVGGAYLFQHLERPHELEVKRDIQNLRVNLTENIWLLSDDAVVLR 96
            ||.:      |.:.::||.|.|.|..:|:.||:|.|...|                   :.:.|.
Mouse    69 WKTV------VAIFVVVVVYLVTGGLVFRALEQPFESSQK-------------------NTIALE 108

  Fly    97 ESDWMANVSKHLA----NFEKQILTAIKADGWD----GDEDLRKSQWTFAGSLFYSIIVITTIGY 153
            :::::.:   |:.    ..|..|..|:.||...    |:.....|.|....:.|::..|||||||
Mouse   109 KAEFLRD---HICVSPQELETLIQHALDADNAGVSPVGNSSNSSSHWDLGSAFFFAGTVITTIGY 170

  Fly   154 GHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGDVMATSF 193
            |:|:|.|:.||:..|.|||.||||....|:.|||.:.|.|
Mouse   171 GNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIF 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	27/54 (50%)
		NESP55	341..586	CDD:115071
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
Kcnk10	NP_001303594.1	Ion_trans_2	<152..206	CDD:369572	27/53 (51%)
Kcnk10	NP_001303594.1	Ion_trans_2	244..323	CDD:369572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9871
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910