DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment galene and kcnk5a

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001032478.1	Gene:	kcnk5a / 570159	ZFINID:	ZDB-GENE-051113-112	Length:	513	Species:	Danio rerio

Alignment Length:	580	Identity:	116/580 - (20%)
Similarity:	203/580 - (35%)	Gaps:	160/580 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LLVLLVVSYCVGGAYLFQHLERPH-ELEVKRDIQNLRVNLTENIWLLSDDAVVLRESDWMANVSK 106
            ||...::.|...||.:||.:|.|: |:.|::              ..:|...:|::...:   :|
Zfish     7 LLTSAIIFYLSIGAAIFQVIEEPNWEIAVRK--------------YRADKESILKQYPCL---TK 54

  Fly   107 HLANFEKQILTAIKADGWDGDEDLRKSQWTFAGSLFYSIIVITTIGYGHISPRTDWGKVTTIFYA 171
            ...::..::::.....|.....|...:.|.:..::.::..||||||||:|:|:|..|:|..|||.
Zfish    55 ADLDYILEVVSDAAGQGITITGDKTFNNWNWPNAVIFAATVITTIGYGNIAPKTPSGRVFCIFYG 119

  Fly   172 IVGIPLMLICLSNIGDVMATSFRFLYWRICCYVCTRTAKRPRNARSRQRSMRS-------QRHAR 229
            :.|:||....:|.:|.......:.|.|.:        .|:....|..|.:..:       ..|.
Zfish   120 LFGVPLCFTWISELGKFFGGRAKHLGWYL--------TKKGVTLRKTQLTCTAVFLLWGVLIHL- 175

  Fly   230 SQPPPSFRRSMKMTQRSGNDSGLGPSMGHAYSDPDLRTMGRGYDDREFGHRSSGGGRNRRQQQQQ 294
            ..||..|     |||     .|.....|..:|...|.|:|       ||...:|
Zfish   176 VIPPFVF-----MTQ-----EGWTYIEGLYFSFVTLTTIG-------FGDLVAG----------- 212

  Fly   295 HLHHDPRQRH-TIYG-----------------DGYETQTLNRSNRYSSRQRQRDRMRDRHTVERE 341
               .||...: |:|.                 ..::.:.:..:::...:.|:|.|:.......:|
Zfish   213 ---VDPNAEYPTLYRYFVEVWIYLGLAWLSLFFNWKVRMVVEAHKALKKHRKRRRLSLDELQLKE 274

  Fly   342 RYSRSHLDAGSIEDFGDMQPPAKRAASVRSVRSPHNQ--------------ESSKASRELHRLHS 392
            .:...||            ||.....::.|..|...:              |:...|....|.::
Zfish   275 SHKTLHL------------PPTPNDVNIFSFLSKKKEGYNDLIKQIGADKGENQCVSTMNSRKNA 327

  Fly   393 APGRSR----AKSVDPRHVSSHYEDVDEDVVRKTPIIPNRYALDDFGGNRRQAAPRSQSMPRSAH 453
            |..||:    |.|::...:.|         :..:|.:...|:..|     |.|...|:|......
Zfish   328 AAKRSKSCSDALSINGNTIVS---------LDGSPRLKRHYSFSD-----RVAVALSKSKGYLFS 378

  Fly   454 QRQ----RQKDRERERSPQPPPQSSYRQQHDRRAG-------SLGRQSSRYGNHLELPDYDAPPP 507
            |.:    .:|..|.:...|....|  ..|.|:.||       |.|.::|:.
Zfish   379 QEECLLMTEKLEEGDTDSQCMGMS--ENQLDKEAGESHKALISEGCRNSQI-------------- 427

  Fly   508 GRDHRRDRRGHSQGRYEDYVEESFDEGSLYGDNNYEDYPPERHHSRSREPKRNRRRERAE 567
                ..|.:||....:.:......||.: :.:||.||........:|.||. .|:.|.:|
Zfish   428 ----TWDSKGHQTNMFPNANITFIDEDN-FVNNNREDENDFMPSFKSDEPD-FRKEEDSE 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	22/54 (41%)
		NESP55	341..586	CDD:115071	50/256 (20%)
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
kcnk5a	NP_001032478.1	Ion_trans_2	<81..137	CDD:285168	22/55 (40%)
kcnk5a	NP_001032478.1	Ion_trans_2	171..243	CDD:285168	20/103 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910