Protein Alignment galene and kcnk18

DIOPT Version :10

• Sequence 1: NP_612084.1
• Gene: galene / 38133
• FlyBaseID: FBgn0035192
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001177236.2
• Gene: kcnk18 / 561821
• ZFINID: ZDB-GENE-100405-2
• Length: 391
• Species: Danio rerio
• Alignment Length: 703
• Identity: 130/703 - (18%)
• Similarity: 207/703 - (29%)
• Gaps: 336/703 - (47%)

  Fly    22 GRCVAAICFSWKVLTCIVSHVLLVLLVVSYCVGGAYLFQHLERPHELEVKRDIQNLRVNLTENIW 86
            |||....   |:    :..||.|:|.:|.|.|.||.:|:.:|..:......:|.::...:.|
Zfish    11 GRCSTLF---WR----LFPHVFLILSLVLYAVLGALVFRAIEYTNPRNESEEILSIVQKVME--- 65

  Fly    87 LLSDDAVVLRESDWMANVSKHLANFEKQILTAIKADGWDGDEDLRKSQWTFAGSLFYSIIVITTI 151
                  :|...:|  |:..|||.|..|.||     |.:..::: |...|||..|||:...|.||:
Zfish    66 ------IVQNHTD--ASEQKHLINKAKYIL-----DDYCYEKE-RDHGWTFFASLFFCCTVFTTV 116

  Fly   152 GYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGDVMATSFRFLYWRICCYVCTRTAKRPRNAR 216
            |||.|.|.|..|||..:.||:|||||||:.:|::||::|......|.|:..:
Zfish   117 GYGRIYPLTSKGKVACVLYAMVGIPLMLLVISDVGDLLAVLLSKAYTRLNLF------------- 168

  Fly   217 SRQRSMRSQRHARSQPPPSFRRSMKMTQRSGNDSGLGPSMGHAYSDPDLRTMGRGYDDREFGHRS 281
                               |||.:                                     ||:|
Zfish   169 -------------------FRRWI-------------------------------------GHQS 177

  Fly   282 SGGGRNRRQQQQQHLHHDPRQRHTIYGDGYETQTLNRSNRYSSRQRQRDRMRDRHTVERERYSRS 346
                                         :..|:..:::.....|...|
Zfish   178 -----------------------------WRLQSHEKTSALPQAQADTD---------------- 197

  Fly   347 HLDAGSIEDFGDMQPPAKRAASVRSVRSPHNQESSKASRELHRLHSAPGRSRAKSVDPRHVSSHY 411
                                                                          ..|
Zfish   198 --------------------------------------------------------------GTY 200

  Fly   412 EDVDEDVVRKTPIIPNRYALDDFGGNRRQAAPRSQSMPRSAHQRQRQK---DRERERSPQPPPQS 473
            :...:.||.:|.             |.:|......|:.|.:.|.:..|   ||...|       .
Zfish   201 KFNQDVVVLETT-------------NNQQVIQTRSSIRRGSFQLRNNKEIFDRIIVR-------E 245

  Fly   474 SYRQQHDRRAGSLGRQSSRYGNHLELPDYDAPPPGRDHRRDRRGHSQGRYEDYVEESFDEGSLYG 538
            |:|.:     |:|.:..|       .|:.|..|..:|                        .|:.
Zfish   246 SFRIK-----GTLSKSCS-------CPELDRVPTPKD------------------------ELFN 274

  Fly   539 DNNYEDYPPERHHSRSREPKRNRRRERAERLPPSPRIMSPMGFPVQRQIRRRPSYDYDDDDSMYG 603
            |...|                      .|:|
Zfish   275 DIGQE----------------------MEQL---------------------------------- 283

  Fly   604 DEYGDYGDLLPKDRPVPIWLCVFLVVSYILGGAVLFAYWE-NWSFLDSAYFCFITLTTIGFGDFV 667
                          .||:.:.:.:|.:|::..:.:...|| .....|:.||.|||||||||||.|
Zfish   284 --------------DVPLLVILLMVFAYMVICSQILKCWEKQMDHSDAFYFTFITLTTIGFGDIV 334

  Fly   668 PAKGVKDESEQSIAYCSLYLLFGIALLAMSFNLVQEEFIANVKEVARRLGILK 720
            |      |..:......|:::.|:|:::|:|.|.|.:.:...:...:.|.:.|
Zfish   335 P------EHPKFFMVTFLFIITGMAIMSMAFKLGQSQIVCFYRRCIKSLSMGK 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	115..189	CDD:462301	34/73 (47%)
		Ion_trans_2	626..706	CDD:462301	28/80 (35%)
kcnk18	NP_001177236.2	Ion_trans_2	<100..154	CDD:462301	30/53 (57%)
		Ion_trans_2	289..367	CDD:462301	28/83 (34%)