DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment galene and KCNK9

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_011515403.1	Gene:	KCNK9 / 51305	HGNCID:	6283	Length:	401	Species:	Homo sapiens

Alignment Length:	168	Identity:	58/168 - (34%)
Similarity:	82/168 - (48%)	Gaps:	40/168 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LVLLVVSYCVGGAYLFQHLERPHEL--EVKRDIQNLRVNLTENIWLLSDD-----AVVLRESDWM 101
            |::...:|.:.||.:|..||..||:  |.|...:.:|:....||  .|:|     .|:|:.....
Human    11 LIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNI--SSEDYRQLELVILQSEPHR 73

  Fly   102 ANVSKHLANFEKQILTAIKADGWDGDEDLRKSQWTFAGSLFYSIIVITTIGYGHISPRTDWGKVT 166
            |.|                             ||.||||.:::|.|||||||||.:|.||.||..
Human    74 AGV-----------------------------QWKFAGSFYFAITVITTIGYGHAAPGTDAGKAF 109

  Fly   167 TIFYAIVGIPLMLICLSNIGDVMATSFRFLYWRI--CC 202
            .:|||::||||.|:...::|:.|.|..|:|..||  ||
Human   110 CMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCC 147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	30/54 (56%)
		NESP55	341..586	CDD:115071
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
KCNK9	XP_011515403.1	Ion_trans_2	<77..132	CDD:285168	30/54 (56%)
KCNK9	XP_011515403.1	Ion_trans_2	170..243	CDD:285168
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2198
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860