Protein Alignment galene and Kcnk18

DIOPT Version :10

• Sequence 1: NP_612084.1
• Gene: galene / 38133
• FlyBaseID: FBgn0035192
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001003820.1
• Gene: Kcnk18 / 445371
• RGDID: 1303091
• Length: 405
• Species: Rattus norvegicus
• Alignment Length: 700
• Identity: 123/700 - (17%)
• Similarity: 194/700 - (27%)
• Gaps: 360/700 - (51%)

  Fly    22 GRCVAAICFSWKVLTCIVSHVLLVLLVVSYCVGGAYLFQHLE-RP-----HELEVKRDIQN---- 76
            |:.:..:||    |.|:|::.|:          ||.||..:| ||     ...|:|:.:..
  Rat    40 GKLLPGLCF----LCCLVTYALV----------GAALFSAVEGRPDPEAEENPELKKFLDKLCNI 90

  Fly    77 LRVNLTENIWLLSDDAVVLRESDWMANVSKHLANFEKQILTAIKADGWDGDEDLRKSQWTFAGSL 141
            |:.|||           |:..|  ..::.:||...:.|...|        .||     |:|..:|
  Rat    91 LKCNLT-----------VVEGS--RKDLCEHLQQLKPQWFKA--------PED-----WSFLSAL 129

  Fly   142 FYSIIVITTIGYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGDVMATSFRFLYWRICCYVCT 206
            |:...|.:|:||||:.|.|..||...:.||:.|||||.:.|::|||::|......|.|....:|.
  Rat   130 FFCCTVFSTVGYGHMYPVTRLGKFLCMLYALFGIPLMFLVLTDIGDILAAILSRAYSRFQALLCL 194

  Fly   207 RTAKRPRNARSRQRSMRSQRHARSQPPPSFRRSMKMTQRSGNDSGLGPSMGHAYSDPDLRTMGRG 271
                 ||:....:..:..::...|:|..
  Rat   195 -----PRDISKWRPLLLCRKQTDSKPAD------------------------------------- 217

  Fly   272 YDDREFGHRSSGGGRNRRQQQQQHLHHDPRQRHTIYGDGYETQTLNRSNRYSSRQRQRDRMRDRH 336
                                                                             
  Rat   218 ----------------------------------------------------------------- 217

  Fly   337 TVERERYSRSHLDAGSIEDFGDMQPPAKRAASVRSVRSPHNQESSKASRELHRLHSAPGRSRAKS 401
                |...:..:|||: ::..|.||                      |||
  Rat   218 ----EAIPQIVIDAGA-DELLDPQP----------------------SRE--------------- 240

  Fly   402 VDPRHVSSHYEDVDEDVVRKTPIIPNRYALDDFGGNRRQAAPRSQSMPRSAHQRQRQKDRERERS 466
                                                     |.|.|.  :....:|...||::..
  Rat   241 -----------------------------------------PASPSC--NVELFERLVAREKQNE 262

  Fly   467 PQPPPQSSYRQQHDRRAGSLGRQSSRYGNHLELPDYDAPPPGRDHRRDRRGHSQGRYEDYVEESF 531
            .|||.                |...|..:..||                   ..||....:..:.
  Rat   263 LQPPM----------------RPVERSNSCPEL-------------------VLGRLSCSILSNL 292

  Fly   532 DEGSLYGDNNYEDYPPERHHSRSREPKRNRRRERAERLPPSPRIMSPMGFPVQRQIRRRPSYDYD 596
            ||                                                 |.:|:.|
  Rat   293 DE-------------------------------------------------VGQQVER------- 301

  Fly   597 DDDSMYGDEYGDYGDLLPKDRPVPIWLCVFLVVSYILGGAVLFAYWE-NWSFLDSAYFCFITLTT 660
                              .|.|:|:  ...::.:||...|.:..:|| :..|.|:.||||:||||
  Rat   302 ------------------LDIPLPV--IALVIFAYISCAAAILPFWETDLGFEDAFYFCFVTLTT 346

  Fly   661 IGFGDFVPAKGVKDESEQSIAYCSLYLLFGIALLAMSFNLVQEEFIANVK 710
            |||||.|..      ......:.|:|::.|:.:|.::|.|:|...:...|
  Rat   347 IGFGDIVLV------HPHFFLFFSIYIIVGMEILFIAFKLMQNRLLHTYK 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	115..189	CDD:462301	28/73 (38%)
		Ion_trans_2	626..706	CDD:462301	28/80 (35%)
Kcnk18	NP_001003820.1	Ion_trans_2	116..177	CDD:462301	28/73 (38%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	138..143		3/4 (75%)
		Interaction with calcineurin. /evidence=ECO:0000250|UniProtKB:Q6VV64	221..226		0/4 (0%)
		Interaction with YWHAH. /evidence=ECO:0000250|UniProtKB:Q6VV64	272..277		1/4 (25%)
		Ion_trans_2	308..385	CDD:462301	28/84 (33%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:Q7Z418	346..351		4/4 (100%)