DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment galene and KCNQ2

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001369164.1	Gene:	KCNQ2 / 3785	HGNCID:	6296	Length:	890	Species:	Homo sapiens

Alignment Length:	740	Identity:	140/740 - (18%)
Similarity:	229/740 - (30%)	Gaps:	245/740 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RGRCVAAICFSWKVLTCIVSHVLLVLLVVSYCV------GGAYLFQHLERPHELEVKRDIQNLRV 79
            |||    :.|:.|.. |::.   :::|:.|..|      |..:....|.....|::.|.|   |:
Human   158 RGR----LKFARKPF-CVID---IMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMI---RM 211

  Fly    80 NLTENIWLLSDDAVVLRESD-----WMANVSKHLANFEKQILTAIKADGWDGDEDLRKSQWTFAG 139
            :.....|.|....|.....:     ::..:...||:|...:....:.|.:|          |:|.
Human   212 DRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFD----------TYAD 266

  Fly   140 SLFYSIIVITTIGYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGDVMATSFRFLY------- 197
            :|::.:|.:||||||...|:|..|::....:.::|:....:....:|...|...:..:
Human   267 ALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEK 331

  Fly   198 ------------WRICCYVCTRT--------------------------AKR---PRNARSRQRS 221
                        ||......:||                          |.|   |.|.....|:
Human   332 RRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRN 396

  Fly   222 MRSQRHA--RSQPPPSFRRSMKMTQRSGNDSGLGPSMGHAYSDP-DLRTMGRGYDDREFGHRSSG 283
            ::|:...  |..|||....|.|::.:.           ..:|.| .:...|:|....:...||..
Human   397 LKSKSGLAFRKDPPPEPSPSQKVSLKD-----------RVFSSPRGVAAKGKGSPQAQTVRRSPS 450

  Fly   284 GGRNRRQQQQQHLHHDPRQRHTIYGDGYETQTLNRSNRYSSRQRQRDRMRDRHTVERERYSRSHL 348
            .        .|.|...|.:             :.:|..:..|.|.|...|.:....|:....:.|
Human   451 A--------DQSLEDSPSK-------------VPKSWSFGDRSRARQAFRIKGAASRQNSEEASL 494

  Fly   349 DAGSIED---------FGDMQPPAKRAASVRSVRSPHNQESSKASRELHRLHS--------APGR 396
            ....|.|         ..|:.|..|  .|:|:|.......|.:..:|..|.:.        :.|.
Human   495 PGEDIVDDKSCPCEFVTEDLTPGLK--VSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGH 557

  Fly   397 ----SRAKSVD--------------PRH-------------VSSHYEDVDEDVVRKTPIIPNRYA 430
                ||.||:.              |||             .|..|....:.:|.:.|.|.::
Human   558 LDMLSRIKSLQSRIDMIVGPPPPSTPRHKKYPTKGPTAPPRESPQYSPRVDQIVGRGPAITDK-- 620

  Fly   431 LDDFGGNRRQAAPRSQSMPRSAHQRQRQ-----------------------KDRE-----RERSP 467
             |...|......|...||.....:.::|                       .:.|     :|..|
Human   621 -DRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFGAKEPEP 684

  Fly   468 QPP---PQSSYRQQHDRRAG---SLGRQSSRYGNHLELPDYDAPPPG-----------RDHRRDR 515
            .||   |:.|  ::|..|.|   .:.|.||..|.    .::.|||..           :.....|
Human   685 APPYHSPEDS--REHVDRHGCIVKIVRSSSSTGQ----KNFSAPPAAPPVQCPPSTSWQPQSHPR 743

  Fly   516 RGHSQGRYEDYVEESFDEGSLYGDNNYEDYPPERHHSRSREPKRNRRRERAE--RLPPSPRIMSP 578
            :||......|:       |||.      ..||...|.||........|...|  |...:|....|
Human   744 QGHGTSPVGDH-------GSLV------RIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPP 795

  Fly   579 MGFPVQRQIRRR------PSYDYDD 597
            .|     .:|..      ||.|:::
Human   796 EG-----NLRDSDTSISIPSVDHEE 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	15/54 (28%)
		NESP55	341..586	CDD:115071	66/339 (19%)
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
KCNQ2	NP_001369164.1	Ion_trans	92..324	CDD:395416	39/186 (21%)
		KCNQ_channel	448..669	CDD:397540	41/246 (17%)
		KCNQ2_u3	684..774	CDD:406935	27/108 (25%)
		KCNQC3-Ank-G_bd	786..886	CDD:403240	7/35 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D774951at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010