DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment galene and KCNK1

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_002236.1	Gene:	KCNK1 / 3775	HGNCID:	6272	Length:	336	Species:	Homo sapiens

Alignment Length:	185	Identity:	53/185 - (28%)
Similarity:	86/185 - (46%)	Gaps:	43/185 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AAICFSWKVLTCIVSHVLLVLLVVSYCVGGAYLFQHLERPHELEVKRDIQNLRVNLTENIWLLSD 90
            :|.||.:           |||..:.|.|.||.:|..:|.|:|..::::::.|:....|....||:
Human    19 SAWCFGF-----------LVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSE 72

  Fly    91 DAV------VLRESDWMANVSKHLANFEKQILTAIKADG-WDGDEDLRKSQWTFAGSLFYSIIVI 148
            ..:      ||..|::..:|   |:|          |.| |:         |.|..:||::..|:
Human    73 QQLEQFLGRVLEASNYGVSV---LSN----------ASGNWN---------WDFTSALFFASTVL 115

  Fly   149 TTIGYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGD---VMATSFRFLYWRI 200
            :|.||||..|.:|.||...|.|:::|||..|:.|:.:..   |..|....||:.|
Human   116 STTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVLYFHI 170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	21/57 (37%)
		NESP55	341..586	CDD:115071
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
KCNK1	NP_002236.1	Ion_trans_2	<101..157	CDD:400301	21/64 (33%)
		pore-forming domain	107..123		7/15 (47%)
		Ion_trans_2	192..267	CDD:400301
		pore-forming domain	212..238
		Important for intracellular retention in recycling endosomes. /evidence=ECO:0000269\|PubMed:19959478	293..299
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10857
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	121	1.000	Inparanoid score	I4753
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860