Protein Alignment galene and twk-48

DIOPT Version :10

• Sequence 1: NP_612084.1
• Gene: galene / 38133
• FlyBaseID: FBgn0035192
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001022681.1
• Gene: twk-48 / 3565640
• WormBaseID: WBGene00010784
• Length: 372
• Species: Caenorhabditis elegans
• Alignment Length: 707
• Identity: 153/707 - (21%)
• Similarity: 217/707 - (30%)
• Gaps: 342/707 - (48%)

  Fly    20 QRGRCVAAICFSWKVLTCIVSHVLLVLLVVSYCVGGAYLFQHLERPHELEVKRDIQNLRVNLTEN 84
            :|.:....:....|::....||:.|..|||.|.:.||.:|:.:|.|||.|::..:::.|....:.
 Worm     6 RRSKVTRVVNLVKKIIAFFFSHIGLCALVVGYALLGAVIFKAVEGPHEAEIQELVKSAREKAVDV 70

  Fly    85 IWLLSDDAVVLRESDWMANVSKHLANFEKQILTAIKADGWDGDEDLRKSQWTFAGSLFYSIIVIT 149
            :|..:.....|....|...|...:..|:...:.:|: .|:||.|..:::||||.|:..||:.|||
 Worm    71 VWNATFRVNRLDSKQWKKTVLDEVKRFKTVCMLSIR-KGYDGKEYGKQAQWTFTGAFLYSLTVIT 134

  Fly   150 TIGYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGDVMATSFRFLYWRICCYVCTRTAKRPRN 214
            |||||:.:.:|..||..|:.|||:||||||:.|:|||||||..|||||
 Worm   135 TIGYGNTAAKTYIGKTLTMLYAIIGIPLMLLFLTNIGDVMAKIFRFLY----------------- 182

  Fly   215 ARSRQRSMRSQRHARSQPPPSFRRSMKMTQRSGNDSGLGPSMGHAYSDPDLRTMGRGYDDREFGH 279
                              ..|.|...::.
 Worm   183 ------------------AQSIRLKFRLI------------------------------------ 193

  Fly   280 RSSGGGRNRRQQQQQHLHHDPRQRHTIYGDGYETQTLNRSNRYSSRQRQRDRMRDRHTVERERYS 344
                            |.|..|
 Worm   194 ----------------LWHKKR------------------------------------------- 199

  Fly   345 RSHLDAGSIEDFGDMQPPAKRAASVRSVRSPHNQESSKASRELHRLHSAPGRSRAKSVDPRHVSS 409
                                :||.:|                           ||.|:..|....
 Worm   200 --------------------KAAKIR---------------------------RANSLVSRLTRG 217

  Fly   410 HYEDVDEDVVRKTPIIPNRYALDDFGGNRRQAAPRSQSMPRSAHQRQRQKDRERERSPQPPPQSS 474
            |....|..|             |.||
 Worm   218 HRVKADSSV-------------DSFG--------------------------------------- 230

  Fly   475 YRQQHDRRAGSLGRQSSRYGNHLELPDYDAPPPGRDHRRDRRGHSQGRYEDYVEESFDEGSLYGD 539
                       ||                   .|.|            .||.:.
 Worm   231 -----------LG-------------------AGAD------------VEDLLT----------- 242

  Fly   540 NNYEDYPPERHHSRSREPKRNRRRERAERLPPSPRIMSPMGFPVQRQIRRRPSYDYDDDDSMYGD 604
                        :|....:...|...|.:|                             :||
 Worm   243 ------------ARVEMEQLEVRETAAAQL-----------------------------ESM--- 263

  Fly   605 EYGDYGDLLPKDRPVPIWLCVFLVVSYILGGAVLFAYWENWSFLDSAYFCFITLTTIGFGDFVPA 669
                         .|||.|.||.::.|:..|..:|..||.|:||:|.|||||:||||||||..|:
 Worm   264 -------------TVPISLVVFTMLGYLGVGTTIFKVWEGWTFLESFYFCFISLTTIGFGDKFPS 315

  Fly   670 KGVK--DESEQSIAYCSLYLLFGIALLAMSFNLVQEEFIANVKEVARRLGILKDDDD 724
            ..|.  ||:::.:...|:|||||:|||||.|||.|||.....:.:|.:....:||||
 Worm   316 TSVSNTDEAQEKLVITSIYLLFGMALLAMCFNLAQEEVQNKTRWIADKFRSKEDDDD 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	115..189	CDD:462301	38/73 (52%)
		Ion_trans_2	626..706	CDD:462301	44/81 (54%)
twk-48	NP_001022681.1	Ion_trans_2	<120..176	CDD:462301	34/55 (62%)
		Ion_trans_2	272..355	CDD:462301	44/82 (54%)