DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment galene and twk-25

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_502170.4	Gene:	twk-25 / 192076	WormBaseID:	WBGene00006678	Length:	683	Species:	Caenorhabditis elegans

Alignment Length:	174	Identity:	47/174 - (27%)
Similarity:	81/174 - (46%)	Gaps:	25/174 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 HVLLVLLVVSYCVGGAYLFQHLERPHELEV----KRDIQNLRVNLTENIWLLSDDAVVLRESDWM 101
            ||.::|||:.|.:.||.||..:|..||.|.    ||.:..:...:.:.:.|...|.:.|..   :
Worm   289 HVCMLLLVLLYTLLGAALFFSIESRHEHETMHFHKRKLDRIIYEIAQTLELEVLDPMKLTN---I 350

  Fly   102 ANVSKHLANFEKQILTAIKADGWDGD-----EDLRKSQWTFAGSLFYSIIVITTIGYGHISPRTD 161
            ..:...:.....::|.|  .|.:.|.     ||.:..:||:..:.|:|:.|.||.|||.|:|.:.
Worm   351 TQMEYFITRAYVKLLNA--EDLYSGSTFYKHEDPKNLKWTYGSAFFFSMNVYTTTGYGSIAPSSS 413

  Fly   162 WGKVTTIFYAIVGIPLMLICLSNIGD-----------VMATSFR 194
            .||...|.|.::.:||..:.:.::|.           ::..|||
Worm   414 LGKALVIVYGLIFVPLTAVVIRDLGQWALLYLTKMYTILIDSFR 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	19/65 (29%)
		NESP55	341..586	CDD:115071
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
twk-25	NP_502170.4	Ion_trans_2	370..440	CDD:285168	22/69 (32%)
		Ion_trans	<482..555	CDD:278921
		Ion_trans_2	482..551	CDD:285168
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010