DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment galene and twk-32

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_506416.2	Gene:	twk-32 / 192075	WormBaseID:	WBGene00006684	Length:	614	Species:	Caenorhabditis elegans

Alignment Length:	206	Identity:	47/206 - (22%)
Similarity:	83/206 - (40%)	Gaps:	36/206 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VLTCIVSHVLLVLLVVSYCVGGAY---LFQHLERPHELEVKRDIQNLRVNLTENIWLLSD----- 90
            |....:.|:.|:::.:.|.|.|.:   |.::.::.....:..|  ..|.|..:.:.|:.:
Worm    29 VFRLALPHITLLVVSILYAVFGGWMLTLIKYSQQTTHQAIMFD--QTRQNFAKRLALIGNKEEFE 91

  Fly    91 ---DAVVLRESDWMANVSKHL---ANFEKQILTAIKADGWDGDEDLRKSQWTFAGSLFYSIIVIT 149
               |.:|.:..|:......|.   |.|....||                  .|..:||::...:|
Worm    92 SIVDELVEKTYDFYTMEDGHRWQEAAFNANPLT------------------NFTSNLFFAATTLT 138

  Fly   150 TIGYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGDVMATSFRFLYWRICCYV--CTRTAKRP 212
            :||||..:|.:..|:|..:.|...||||.||.::::...........|..|..|.  ..|..||.
Worm   139 SIGYGIDAPESLIGRVFCLVYLFFGIPLYLITIADMAKFCTELMNRTYTEIIKYKYRVKRRYKRW 203

  Fly   213 RNARSRQRSMR 223
            ::.|.|:.||:
Worm   204 KSGRIRRESMK 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	18/54 (33%)
		NESP55	341..586	CDD:115071
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
twk-32	NP_506416.2	Ion_trans_2	<125..180	CDD:285168	18/54 (33%)
		Ion_trans_2	251..325	CDD:285168
		FN3	392..485	CDD:238020
		FN3	491..580	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810