DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment galene and twk-7

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_498903.3	Gene:	twk-7 / 192073	WormBaseID:	WBGene00006662	Length:	557	Species:	Caenorhabditis elegans

Alignment Length:	184	Identity:	57/184 - (30%)
Similarity:	102/184 - (55%)	Gaps:	32/184 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 KVLTCIVSHVLLVLLVVSYCVGGAYLFQHLERPHELEVKRDIQNLRVNLT-ENIWLLSDDAVVL- 95
            |....::.||.||||..:|.|.||.:|..:|:|||..:|.  |.|::..| :|.::  ||.:.|
Worm   157 KFAKLVLPHVALVLLTCTYTVIGALIFYSVEQPHEQMMKE--QQLKLIYTRQNEFV--DDLIRLA 217

  Fly    96 -----RESDWMANVSKHLAN--------FEKQILTAIKADGWDGDEDLRKS----QWTFAGSLFY 143
                 :..:|.:...:|:.|        |||..||:         .:::|:    .|||:.|:|:
Worm   218 AGNETKRYEWESLAERHMHNMSDQLFVAFEKYFLTS---------NEVKKNAATETWTFSSSIFF 273

  Fly   144 SIIVITTIGYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGDVMATSFRFLY 197
            ::.|:||||||:..|.|:.|::..|.::::||||.|:.::::|..::....:||
Worm   274 AVTVVTTIGYGNPVPVTNIGRIWCILFSLLGIPLTLVTIADLGKFLSEHLVWLY 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	22/54 (41%)
		NESP55	341..586	CDD:115071
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
twk-7	NP_498903.3	Ion_trans_2	<263..321	CDD:285168	22/57 (39%)
		Ion_trans	<371..>418	CDD:278921
		Ion_trans_2	377..>422	CDD:285168
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2198
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870