DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment galene and twk-2

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001350984.1	Gene:	twk-2 / 188452	WormBaseID:	WBGene00006657	Length:	1519	Species:	Caenorhabditis elegans

Alignment Length:	665	Identity:	128/665 - (19%)
Similarity:	215/665 - (32%)	Gaps:	232/665 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MLEPAKP--------QRGRCVAAICFSWKVLTCIVSHVLLVLLVVSYCVGGAYLFQHLERPHELE 69
            :||.|:|        |..|..|.:.         :.|::||:.|..|...||::|..||.|:|..
Worm    10 LLESARPDDETTTTLQNIRKYAKLA---------LPHIVLVVCVCIYATIGAWIFYTLESPNEDR 65

  Fly    70 VK----RDIQNLRVNLTENIWLLSDDAVVLRESDWMANVSKHLANFEKQILTAIK---------- 120
            :|    :.|..:|.||   |:.::::    .:..|..::.|.|..:.:::..|.|
Worm    66 LKETGRKTIAEMRSNL---IYKINNN----EKEVWKEDIEKELMLYSEKLYKAFKEQYVRYSDVR 123

  Fly   121 ------------ADGWDGDEDLRK--------------SQWTFAGSLFYSIIVITTIGYGHISPR 159
                        ||...||.:.::              ..||.:.:||::...:.|||||:|.|.
Worm   124 TIGFEGRSSYEEADETGGDSERKRRHRHGNKRGDRGSEKMWTTSSALFFAATTMATIGYGNIVPV 188

  Fly   160 TDWGKVTTIFYAIVGIPLMLICLSNIGDVMATSFRFLYWRICCYVCTRTAKRPRNARSR------ 218
            |..|::..:.:|:.|.|:.:|.:.::|..::....:||            |..|...:|
Worm   189 TPLGRLACVLFALFGAPIAIITIGDLGKFLSECTIWLY------------KHMRKGSARLDSAWK 241

  Fly   219 -----QRSMRSQRHARSQPPPSFRRSMKMTQRSGND----------------------------- 249
                 :.|:.....:.|:...|....|.|.:...::
Worm   242 RFRGLEDSISDDLESASKNQDSSILDMDMDEIDKSEVPVLMVFTIILLYIAFGGILFSILEDWSY 306

  Fly   250 ---------------------------------SGLGPSM-------------------GHAYSD 262
                                             .|:|.|:                   |..:..
Worm   307 MDAFYYSFISLTTIGFGDIVPENHDYIAIMLIYLGVGLSVTTMCIDLAGIQYIQKIHYFGRKFQG 371

  Fly   263 PDL-------------RTMGRGYDD-REFGHRSSGGGRNRRQQQQQHLHHDPRQRHTIYGDGYET 313
            .||             ..||:|.:. |::.|......|.:.|.||:....||   .:|...|::.
Worm   372 TDLLQYLKKKRMLERRLAMGQGEEILRKYVHAVEKFEREQEQLQQKMEEEDP---PSIESKGFDN 433

  Fly   314 QTLNRSNRYSSRQRQRDRMRDRHTVERERYSRSHLDAGSIEDFGDMQPPAKRAASVRSVRSPHNQ 378
            ..:...:..|:.|.   |..|       .|....|.:.:|......||.....:|.||......|
Worm   434 SMMRIDDSLSAFQL---RFYD-------TYDEEDLFSPTIHSVRSFQPSVWSHSSARSQSFCRFQ 488

  Fly   379 ESSKASRELHRLHSAPGRSR--AKSVDPR-HVS----SHYEDVDEDVVR------KTPIIPNRYA 430
            .:..||.:    .|.|..|.  :.|.:|. |:.    .:|......|:.      .:|.|.:..:
Worm   489 RNRGASWD----ESGPSLSEHCSLSTEPSVHIRQAYWDNYHSPTPSVISFLHRHLYSPSIASSIS 549

  Fly   431 LD-DFGGNRRQAAPRSQSMPRSAHQRQRQKDRERERSPQPPPQ---SSYRQQHDRRAGSLGRQSS 491
            .| |......::|.||.|.|..             ..|.|||.   ||.|:....|.||..|...
Worm   550 FDYDCLAKDAKSARRSNSCPPI-------------EIPSPPPSNSVSSPRRPLSARTGSTIRTKH 601

  Fly   492 RYGNHLELPDYDAPP 506
            ...:.   |.|.|.|
Worm   602 AIASE---PIYTAAP 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	18/54 (33%)
		NESP55	341..586	CDD:115071	43/183 (23%)
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
twk-2	NP_001350984.1	Ion_trans_2	<164..220	CDD:311712	18/55 (33%)
twk-2	NP_001350984.1	Ion_trans_2	285..360	CDD:311712	3/74 (4%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920