DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment galene and twk-49

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001022268.1	Gene:	twk-49 / 187626	WormBaseID:	WBGene00019904	Length:	337	Species:	Caenorhabditis elegans

Alignment Length:	234	Identity:	59/234 - (25%)
Similarity:	91/234 - (38%)	Gaps:	54/234 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RAQSLPAHMLEPAKPQRGRCVAAI---CFS-WKVLTCIVSHVLLVLLVVSYCVGGAYLFQHLER- 64
            |..:....|||..|....|..:|.   ||. |       |.|||:||...:.:.||..|...||
Worm    15 RLDTFNQDMLERVKASTSRISSATRSPCFQRW-------SPVLLILLTTVFILFGATCFYLFERD 72

  Fly    65 PHELEVKRDIQNLRV--------------NLTENIWLLSDDAVVLRESDWMANVSKHLANFEKQI 115
            |||:.|::...||.|              |.|.|:.::.|.....|....:.   :.|..:|.:
Worm    73 PHEMTVRKWYMNLAVERRQFARTISSRIFNDTRNLLIIIDREQTERVQQLLV---ESLKRYEDK- 133

  Fly   116 LTAIKADGWDGDEDLRKSQWTFAGSLFYSIIVITTIGYGHISPRTDWGKVTTIFYAIVGIPLMLI 180
            ||.:...         :.:|::..|..::..::.|||.|...|.|...::..:||.::||||...
Worm   134 LTIVPPS---------RREWSWISSFNFAYSLLLTIGGGFKVPATVGSQIFAVFYCLIGIPLFYS 189

  Fly   181 CLSNIGDVMATSFRFLYWRICCYVCTRTAKRPRNARSRQ 219
            .|.               .|.|.:.:...|.|...|||:
Worm   190 TLI---------------LIVCRLVSPVLKWPSLTRSRR 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	15/54 (28%)
		NESP55	341..586	CDD:115071
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
twk-49	NP_001022268.1	Ion_trans_2	<144..191	CDD:369572	14/46 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010