Protein Alignment galene and twk-28

DIOPT Version :10

• Sequence 1: NP_612084.1
• Gene: galene / 38133
• FlyBaseID: FBgn0035192
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_508732.3
• Gene: twk-28 / 183714
• WormBaseID: WBGene00006680
• Length: 523
• Species: Caenorhabditis elegans
• Alignment Length: 706
• Identity: 117/706 - (16%)
• Similarity: 195/706 - (27%)
• Gaps: 412/706 - (58%)

  Fly    38 IVSHVLLVLLVVSYCVGGAYLFQHLERPHELEVKR----DIQNLRVNLTENIWLLSDDA--VVLR 96
            |:.||.||:|:..|.:.||:||::||.|.|||.:.    .|..||....::||.::.|:  .:.|
 Worm    59 ILPHVGLVILLFLYLIAGAFLFRYLEAPKELETRNHELTTILGLRDEFQDHIWNITQDSDNRISR 123

  Fly    97 ESDWMAN--------------------VSKHLANFEKQILTAIKADGWDGDEDLRKSQWTFAGSL 141
            |:....|                    .:|||.|..::            ||.|    |||..|:
 Worm   124 EAFNAINQEYFEQLVKNMFQAYRNQFITAKHLLNKTRE------------DEVL----WTFPNSM 172

  Fly   142 FYSIIVITTIGYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGDVMATSFRFLYWRICCYVCT 206
            |::..||||||||::.|.|..|:|..|.:|::||||:|:.:::||..::....:||
 Worm   173 FFAATVITTIGYGNLVPITVTGRVACIIFALLGIPLLLVTIADIGKFLSEFLSYLY--------- 228

  Fly   207 RTAKRPRNARSRQRSMRSQRHARSQPPPSFRRSMKMTQRSGNDSGLGPSMGHAYSDPDLRTMGRG 271
                  |:.|..:|.:|             |:|.|:|.:
 Worm   229 ------RSYRGFKRKLR-------------RQSKKITSQ-------------------------- 248

  Fly   272 YDDREFGHRSSGGGRNRRQQQQQHLHHDPRQRHTIYGDGYETQTLNRSNRYSSRQRQRDRMRDRH 336
                                                   |.:|:.:||:
 Worm   249 ---------------------------------------YRSQSQSRSS---------------- 258

  Fly   337 TVERERYSRSHLDAGSIEDFGDMQPPAKRAASVRSVRSPHNQESSKASRELHRLHSAPGRSRAKS 401
                                                                   |..|.|:|.|
 Worm   259 -------------------------------------------------------SVMGSSKAGS 268

  Fly   402 VDPRHVSSHYEDVDEDVVRKTPIIPNRYALDDFGGNRRQAAPRSQSMPRSAHQRQRQKDRERERS 466
            ::
 Worm   269 MN--------------------------------------------------------------- 270

  Fly   467 PQPPPQSSYRQQHDRRAGSLGRQSSRYGNHLELPDYDAPPPGRDHRRDRRGHSQGRYEDYVEESF 531
                       .||
 Worm   271 -----------LHD--------------------------------------------------- 273

  Fly   532 DEGSLYGDNNYEDYPPERHHSRSREPKRNRRRERAERLPPSPRIMSPMGFPVQRQIRRRPSYDYD 596
                                                                         .|.|
 Worm   274 -------------------------------------------------------------IDSD 277

  Fly   597 DDDSMYGDEYGDYGDLLPKDRPVPIWLCVFLVVSYILGGAVLFAYWENWSFLDSAYFCFITLTTI 661
            .:||. |||.           .:|:::.:.::::|...|..||..||:..:.::.||||||:.|:
 Worm   278 SEDSA-GDEL-----------RIPVFMVLLVLLAYTAIGGFLFQSWEHLEYFEAFYFCFITMATV 330

  Fly   662 GFGDFVPAKGVKDESEQSIAYCSL-YLLFGIALLAMSFNLVQEEFIANVKEVARRL 716
            ||||.||       :||...:.:: |::||::|..|..:|...|:|..:..:..::
 Worm   331 GFGDIVP-------NEQVYVFFTMAYIIFGLSLATMCIDLAGTEYIRKIHYLGTKM 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	115..189	CDD:462301	29/73 (40%)
		Ion_trans_2	626..706	CDD:462301	28/80 (35%)
twk-28	NP_508732.3	Ion_trans_2	<161..222	CDD:462301	29/76 (38%)
		Ion_trans_2	292..370	CDD:462301	28/84 (33%)