Protein Alignment galene and twk-22

DIOPT Version :10

• Sequence 1: NP_612084.1
• Gene: galene / 38133
• FlyBaseID: FBgn0035192
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001361830.1
• Gene: twk-22 / 181703
• WormBaseID: WBGene00006675
• Length: 749
• Species: Caenorhabditis elegans
• Alignment Length: 710
• Identity: 151/710 - (21%)
• Similarity: 246/710 - (34%)
• Gaps: 259/710 - (36%)

  Fly    30 FSWKVLTCIVSHVLLVLLVVSY-CVGGAYLFQHLE---RPHELEVKRDIQNLRVNLTENIWLLSD 90
            |.:|:|.  :.::||.|:::.| |:|| |:|..||   :..:|||::     :|.|:|:..|..:
 Worm   167 FLYKLLG--IQYMLLALMILGYACLGG-YIFLTLEYDQQQLDLEVEK-----QVRLSESTLLAEN 223

  Fly    91 DAVVLRESDW---MANVSKHL-----ANFEKQILTA--IKADGWDGDEDLRKSQWTFAGSLFYSI 145
            ....|::  |   .:|.::.|     |..|:.|...  |:.:||         :|.|..|:|:|.
 Worm   224 LLKYLKQ--WNCGQSNENRCLELITKAFIERSIKVERDIRGEGW---------RWDFWNSVFFSA 277

  Fly   146 IVITTIGYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGD---VMATSFRFLYWRICCYVCTR 207
            .:.||||||:::.:|:.|:|.||.|.::||||||..|...|:   ..|...|:.. |.|...|.|
 Worm   278 TIFTTIGYGNLACKTNLGRVATIIYGLIGIPLMLFVLKIFGEHSIKWAQKVRYSI-RRCVKRCFR 341

  Fly   208 TAKRPRNARSRQRSMRSQRHARSQPPPSFRRSMKMTQRSGNDSGLGPSMGHAYSDP--------- 263
            .:|..|                    .|...|:...:....:||:........:.|
 Worm   342 RSKLKR--------------------ASTIESVASDEMPCEESGISEDEEQITTFPVKWALFIVF 386

  Fly   264 ---------------------------DLRTMGRG------------------------------ 271
                                       .|.|:|.|
 Worm   387 FFMVVCSLIVSFWEKWDFLTAFYFFFVSLSTIGFGDVIPEHPRTACALFVLYFVGLALFSMVYAI 451

  Fly   272 --------------YDDREFGHRSSGGGRNRRQQQQQHLHHDPRQRHTIYGD---GYETQTLNRS 319
                          ..|:|:       ..|::|....||     :..||..:   |.|..| |..
 Worm   452 LQERVENQYMWALELIDQEY-------QENQKQDPDDHL-----EIPTILPENAAGMEGWT-NTI 503

  Fly   320 NRYSSRQRQRDRMRDRHTVERERYSRSHLDAGSIEDFGDMQPPAKRAASVRSVRSPHNQESSKAS 384
            .:..|:...|.|.::              .|.|:|:..| :|.::|..||.|
 Worm   504 GKMVSQNPVRWRAKN--------------SAYSMENMPD-RPISERRFSVLS------------- 540

  Fly   385 RELHRLHSAPGRSRAKSVDPRHVSS---HYEDVDEDVVRKTPIIPNRYALDDFGGNRRQAA--PR 444
                     ||  .|....|..:.:   |...|.:.::.::..|.||      .|.:|.:.  |.
 Worm   541 ---------PG--EAPQAPPPVLGTFMLHSLSVKKKLLARSESILNR------TGTKRPSTLFPS 588

  Fly   445 SQSMPRSA---------HQRQRQKDRERERSPQPPPQSSYRQQHDRRAGSLGRQSSRYGNHL--- 497
            ::.:..||         |..:..:.:|..|..:|   |:.|........|.|.:|.. |..|
 Worm   589 NEMLSTSASSSRGSPWPHAAEMNRPKEATRLGEP---SALRVSAPNLTISGGNRSPS-GGALSVI 649

  Fly   498 -ELPDYDAPPPGRDHRR--------DRRGHSQGRYEDYVEESFDEGSLYGDNNYEDYPPERHHSR 553
             |..|.|. ...:.|||        |....:.|..|. :::..||..|...:......|.|..:.
 Worm   650 TEASDEDT-RHFKKHRRPLAKTVSTDGTVSNHGSAES-LDQVMDELQLESHDQAVTPKPYRDPTT 712

  Fly   554 SREPKRNRRRE-----RAERLPPSPRIMSPMGFPVQRQIRRRPSYDYDDDDSMYGDEYGD 608
            |   .|.|:|:     |||::|.||..:                  .:::|.   ||.||
 Worm   713 S---TRFRKRDETVVSRAEKMPLSPNEV------------------LEEEDE---DENGD 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	115..189	CDD:462301	29/78 (37%)
		Ion_trans_2	626..706	CDD:462301
twk-22	NP_001361830.1	Ion_trans_2	<262..319	CDD:462301	26/65 (40%)
		Ion_trans_2	380..458	CDD:462301	4/77 (5%)