DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment galene and twk-22

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001361830.1	Gene:	twk-22 / 181703	WormBaseID:	WBGene00006675	Length:	749	Species:	Caenorhabditis elegans

Alignment Length:	715	Identity:	150/715 - (20%)
Similarity:	245/715 - (34%)	Gaps:	269/715 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FSWKVLTCIVSHVLLVLLVVSY-CVGGAYLFQHLE---RPHELEVKRDIQNLRVNLTENIWLLSD 90
            |.:|:|.  :.::||.|:::.| |:|| |:|..||   :..:|||::     :|.|:|:..|..:
Worm   167 FLYKLLG--IQYMLLALMILGYACLGG-YIFLTLEYDQQQLDLEVEK-----QVRLSESTLLAEN 223

  Fly    91 DAVVLRESDW---MANVSKHL-----ANFEKQILTA--IKADGWDGDEDLRKSQWTFAGSLFYSI 145
            ....|::  |   .:|.::.|     |..|:.|...  |:.:||         :|.|..|:|:|.
Worm   224 LLKYLKQ--WNCGQSNENRCLELITKAFIERSIKVERDIRGEGW---------RWDFWNSVFFSA 277

  Fly   146 IVITTIGYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGDVMATSFRFLYW--------RICC 202
            .:.||||||:::.:|:.|:|.||.|.::||||||..|...|:      ..:.|        |.|.
Worm   278 TIFTTIGYGNLACKTNLGRVATIIYGLIGIPLMLFVLKIFGE------HSIKWAQKVRYSIRRCV 336

  Fly   203 YVCTRTAKRPRNARSRQRSMRSQRHARSQPPPSFRRSMKMTQRSGNDSGLGPSMGHAYSDP---- 263
            ..|.|.:|..|                    .|...|:...:....:||:........:.|
Worm   337 KRCFRRSKLKR--------------------ASTIESVASDEMPCEESGISEDEEQITTFPVKWA 381

  Fly   264 --------------------------------DLRTMGRG------------------------- 271
                                            .|.|:|.|
Worm   382 LFIVFFFMVVCSLIVSFWEKWDFLTAFYFFFVSLSTIGFGDVIPEHPRTACALFVLYFVGLALFS 446

  Fly   272 -------------------YDDREFGHRSSGGGRNRRQQQQQHLHHDPRQRHTIYGD---GYETQ 314
                               ..|:|:       ..|::|....||     :..||..:   |.|..
Worm   447 MVYAILQERVENQYMWALELIDQEY-------QENQKQDPDDHL-----EIPTILPENAAGMEGW 499

  Fly   315 TLNRSNRYSSRQRQRDRMRDRHTVERERYSRSHLDAGSIEDFGDMQPPAKRAASVRSVRSPHNQE 379
            | |...:..|:...|.|.::              .|.|:|:..| :|.::|..||.|
Worm   500 T-NTIGKMVSQNPVRWRAKN--------------SAYSMENMPD-RPISERRFSVLS-------- 540

  Fly   380 SSKASRELHRLHSAPGRSRAKSVDPRHVSS---HYEDVDEDVVRKTPIIPNRYALDDFGGNRRQA 441
                          ||  .|....|..:.:   |...|.:.::.::..|.||      .|.:|.:
Worm   541 --------------PG--EAPQAPPPVLGTFMLHSLSVKKKLLARSESILNR------TGTKRPS 583

  Fly   442 A--PRSQSMPRSA---------HQRQRQKDRERERSPQPPPQSSYRQQHDRRAGSLGRQSSRYGN 495
            .  |.::.:..||         |..:..:.:|..|..:|   |:.|........|.|.:|.. |.
Worm   584 TLFPSNEMLSTSASSSRGSPWPHAAEMNRPKEATRLGEP---SALRVSAPNLTISGGNRSPS-GG 644

  Fly   496 HL----ELPDYDAPPPGRDHRR--------DRRGHSQGRYEDYVEESFDEGSLYGDNNYEDYPPE 548
            .|    |..|.|. ...:.|||        |....:.|..|. :::..||..|...:......|.
Worm   645 ALSVITEASDEDT-RHFKKHRRPLAKTVSTDGTVSNHGSAES-LDQVMDELQLESHDQAVTPKPY 707

  Fly   549 RHHSRSREPKRNRRRE-----RAERLPPSPRIMSPMGFPVQRQIRRRPSYDYDDDDSMYGDEYGD 608
            |..:.|   .|.|:|:     |||::|.||..:                  .:::|.   ||.||
Worm   708 RDPTTS---TRFRKRDETVVSRAEKMPLSPNEV------------------LEEEDE---DENGD 748

Fly 609 608
Worm 749 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	25/54 (46%)
		NESP55	341..586	CDD:115071	58/275 (21%)
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
twk-22	NP_001361830.1	Ion_trans_2	259..319	CDD:369572	27/68 (40%)
twk-22	NP_001361830.1	Ion_trans_2	381..457	CDD:369572	4/75 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920