DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment galene and twk-17

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001024464.1	Gene:	twk-17 / 181024	WormBaseID:	WBGene00006671	Length:	576	Species:	Caenorhabditis elegans

Alignment Length:	480	Identity:	118/480 - (24%)
Similarity:	189/480 - (39%)	Gaps:	136/480 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 KVLTCIVSHVLLVLLVVSYCVGGAYLFQHLERPHELEVKR-----------DIQNLRVNLTENIW 86
            |:|..::.||.|.:|::||...||.:|..||..||||.::           .|.|..:.||.|
Worm   135 KLLKILLPHVGLNVLLLSYIAMGATVFIWLEADHELEGRKAKVKHVFDIYSQIMNETIALTNN-- 197

  Fly    87 LLSDDA-VVLRESDWMANVSKHLANFEK-----QILTAIKADGWDGDEDLRKSQWTFAGSLFYSI 145
             .||.| :|.|....:.::|:.....:|     |:        |.|::|...::||||.:..|::
Worm   198 -QSDQATIVSRMRPLLESLSRAHEYDDKFTDTNQL--------WTGEQDGMTTRWTFAAATLYAL 253

  Fly   146 IVITTIGYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGD-----VMATSFRFL-YWRICCYV 204
            .|||:.||.|::|.||.|::.|:|:.::|||||.|..::||.     |:.|..:.| .|::...:
Worm   254 TVITSTGYDHVTPATDPGRIFTVFFGLIGIPLMFITAADIGKFLSEIVIRTYAKLLAMWKMIANL 318

  Fly   205 --CTRT----------------AKRPRNARSRQRSMRSQRHARSQ-PPPSFRRSMKMTQRSG--- 247
              ..||                ..:.|||.|...........|.| |..|:     .|...|
Worm   319 VELVRTHLFDTDVDSIDSMELKKSKKRNASSLDDEECEDEEDRLQLPIASY-----FTLIIGYCC 378

  Fly   248 ------NDSGLGP--SMGHA--YSDPDLRTMGRGYDDREFGHRSSGGGRNRRQQQQQHLHHDPRQ 302
                  |....||  |..|.  :|...:.|:|.|               |.|  .|||.:.....
Worm   379 VGSLLFNTFEKGPVWSFIHGVFFSFNTITTIGLG---------------NIR--VQQHYYLALAV 426

  Fly   303 RHTIYGDGYETQTLNRSN----------RYSSRQRQ-------------RDRMRDRHTVERERYS 344
            .:.|.|....|.:|:..:          .|..|:.:             |:.||....:::.|.|
Worm   427 SYVIIGLAVITASLDLCSSTLKRTFTKLHYFGRKIRGARRGFANMSDDIREAMRIIAALKKTRPS 491

  Fly   345 RSHLDAGSIEDFGDMQPPAKRAASVRSVRSPHNQESSKASRELHRLHSAPGRSRAKSVDPR---- 405
            :..:....::.|.::|....|...|     |:|         :|.|     |....:|.|:
Worm   492 KDRITLEDLKRFLEVQEHLLRQPYV-----PYN---------VHLL-----RWIEDNVGPQMKNE 537

  Fly   406 -HVSSHYEDVDEDVV-RKTPIIPNR 428
             .::..|....:||. .|||:.|:|
Worm   538 FSLAEQYAQYMDDVSGGKTPMSPSR 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	25/59 (42%)
		NESP55	341..586	CDD:115071	21/94 (22%)
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
twk-17	NP_001024464.1	Ion_trans_2	<242..299	CDD:285168	25/56 (45%)
twk-17	NP_001024464.1	Ion_trans_2	371..449	CDD:285168	20/94 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010