DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment galene and twk-26

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_508522.2	Gene:	twk-26 / 180592	WormBaseID:	WBGene00006679	Length:	519	Species:	Caenorhabditis elegans

Alignment Length:	502	Identity:	111/502 - (22%)
Similarity:	185/502 - (36%)	Gaps:	144/502 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VSHVLLVLLVVSYCVGGAYLFQHLERPHELEVKRDIQNLRVNLTENIWLLSDDAVVLRESDWMAN 103
            :.||.|:.|:|.|...|.::|:.||.|.|||          :|.|.|.|:  ..::..|:..:.|
Worm    84 IRHVTLIALLVGYVFLGGFMFEKLESPRELE----------DLKETIVLM--QGIIDEETTDIIN 136

  Fly   104 VS---------KHLANFEKQIL-TAIKADG------WDGDEDL-RKSQWTFAGSLFYSIIVITTI 151
            |:         ..||...|:.. |.::|:|      |...|:| ....|.|:.:.|||:.:.:||
Worm   137 VTLSTNGTDRVNKLAKLIKRYYKTMLEAEGRFHGSVWHKAENLDMHLMWYFSSATFYSMTLFSTI 201

  Fly   152 GYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGD----VMATSFRFLYWRICCYVCTRTAKRP 212
            |||.||.:|.||:..::.||.:|:|:||:.|.:||:    ::...:.||..:.     .:..|:|
Worm   202 GYGTISCQTVWGRTLSMIYASIGLPIMLVVLGDIGEWFQKILTNGYIFLLLKY-----KKLRKQP 261

  Fly   213 RNARSRQRSMRSQRHARSQPPPSF-------------RRSMKM-TQRSGNDSGLGPSMGHAYSDP 263
            .|.:..:..:           |.:             ..::|| ....||..|:|......::..
Worm   262 VNRKKNEILL-----------PMWLALFLVLAYILICTLTIKMFDHNEGNKPGIGFFDAFYFTFI 315

  Fly   264 DLRTMGRGYDDREFGHRSSGGGRNRRQQQQQHLHHDP--------------RQRHTIYGDGYETQ 314
            .|.|:|.|                  .....::.:.|              ....:||...|:.
Worm   316 SLTTIGLG------------------DVMPYNIQYSPFLAAAFLLGLALISIVNTSIYAQLYQM- 361

  Fly   315 TLNRSNRYSSRQRQRDRMRDRHTVERERYSRSHLDAGSIEDFGDMQP-------------PAKRA 366
               ..|..:|.:.|.||:          :|.:|...| .:.|.||:|             |..|.
Worm   362 ---FFNMINSVEDQLDRI----------HSSNHKGPG-YKVFHDMEPVFRMLVCTFPPSHPQTRI 412

  Fly   367 ASVRSVRSPHNQESSKASRELHRLHSAPGRSRAKSVDPRHVSSH-----------YEDVDEDV-- 418
            .....||....::..| .||.:.......|:|.:|..|.|...|           .|..:||:
Worm   413 KFAAVVRDSFRRDKEK-KRESNTSDQIKLRTRTESDIPAHDGFHLWMTKRAKKRQMEQENEDLHA 476

  Fly   419 -VRKTPIIPNRYALDDFGGNRRQAAPRSQSMPRSAHQRQRQKDRERE 464
             .|:.|      .|..|||.......|.:|......:...::..|.:
Worm   477 ARRRAP------TLGAFGGFDMNLFKRGRSNTSPFEKNDSEETEESD 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	24/58 (41%)
		NESP55	341..586	CDD:115071	32/151 (21%)
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
twk-26	NP_508522.2	Ion_trans_2	<185..241	CDD:285168	24/55 (44%)
twk-26	NP_508522.2	Ion_trans_2	278..>327	CDD:285168	10/66 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920