Protein Alignment galene and twk-11

DIOPT Version :10

• Sequence 1: NP_612084.1
• Gene: galene / 38133
• FlyBaseID: FBgn0035192
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_504783.2
• Gene: twk-11 / 179088
• WormBaseID: WBGene00006666
• Length: 1720
• Species: Caenorhabditis elegans
• Alignment Length: 718
• Identity: 120/718 - (16%)
• Similarity: 197/718 - (27%)
• Gaps: 395/718 - (55%)

  Fly     5 RAQSLPAHMLEPAKPQRGRCVAAICFSWKVLTCIVSHVLLVLLVVSYCVGGAYLFQHLERPHELE 69
            |..||.|.:.|.|...:.:......|....:..::|...|::::..|...||::|.:||.|.:||
 Worm    39 RPTSLVASIKESAISSKRKLKYYCSFICTPIKKLLSTFKLLIIIGLYSFIGAHIFMYLEVPTDLE 103

  Fly    70 VKRD------------IQNLRVNLTENIWLLSDDAVVLRESDWMANVSKH-LANFEKQILTAIKA 121
            .:.|            :.|||....:|    .:|    ||..|     || :..||:.|
 Worm   104 AREDGFHQRKIAREVMVLNLRAIFYDN----RED----REERW-----KHAILKFEEDI------ 149

  Fly   122 DGWDG-DEDLRKSQWTFAGSLFYSIIVITTIGYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNI 185
                | :|.:.::.|||..|..|:..:.||||||:|:.:|..|::.|:.||.||||:||:.|:::
 Worm   150 ----GLEEPVIETVWTFWMSFLYAGTIFTTIGYGNIACKTRAGQIATMVYAFVGIPIMLVMLTSL 210

  Fly   186 GDVMATSFRFLYWRICCYVCTRTAKRPRNARSRQRSMRSQRHARSQPPPSFRRSMKMTQRSGNDS 250
            .:.:      |.|                                         :|:.....:|.
 Worm   211 NNFL------LKW-----------------------------------------IKLITNGVSDM 228

  Fly   251 GL--GPSMGHAYSDPDLRTMGRGYDDREFGHRSSGGGRNRRQQQQQHLHHDPRQRHTIYGDGYET 313
            .|  |..:|....                          |:.:.|:.|
 Worm   229 TLYIGVRLGITVI--------------------------RQDEVQKRL----------------- 250

  Fly   314 QTLNRSNRYSSRQRQRDRMRDRHTVERERYSRSHLDAGSIEDFGDMQPPAKRAASVRSVRSPHNQ 378
                   ||:...:         |::|.:.|:                              |..
 Worm   251 -------RYTKLAK---------TMKRWKLSK------------------------------HGA 269

  Fly   379 ESSKA--SRELHRLHSAPGRSRAKSVDPRHVSSHYEDVDEDVVRKTPIIPNRYALDDFGGNRRQA 441
            .||.|  :.|.:||:|.|                     ||
 Worm   270 PSSIAISNSEENRLNSTP---------------------ED------------------------ 289

  Fly   442 APRSQSMPRSAHQRQRQKDRERERSPQPPPQSSYRQQHDRRAGSLGRQSSRYGNHLELPDYDAPP 506
                              |.|.|...|.||
 Worm   290 ------------------DEEEEEIHQDPP----------------------------------- 301

  Fly   507 PGRDHRRDRRGHSQGRYEDYVEESFDEGSLYGDNNYEDYPPERHHSRSREPKRNRRRERAERLPP 571
                                                                             
 Worm   302 ----------------------------------------------------------------- 301

  Fly   572 SPRIMSPMGFPVQRQIRRRPSYDYDDDDSMYGDEYGDYGDLLPKDRPVPIWLCVFLVVSYILGGA 636
               ::|.:                                              ...|::|:..|
 Worm   302 ---VLSTL----------------------------------------------IATVAWIILSA 317

  Fly   637 VLFAYWENWSFLDSAYFCFITLTTIGFGDFVPAKGVKDESEQSIAYCSLYLLFGIALLAMSFNLV 701
            .:|..:|:|:|..|.|||||:|||||.||..||     ..|..||...: ::.|:::|.:..:::
 Worm   318 AVFCLFEDWTFFTSFYFCFISLTTIGLGDVTPA-----NPEYMIATFGV-VIVGLSMLTVCIDVL 376

  Fly   702 QEE 704
            ||:
 Worm   377 QEK 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	115..189	CDD:462301	27/74 (36%)
		Ion_trans_2	626..706	CDD:462301	29/79 (37%)
twk-11	NP_504783.2	Ion_trans_2	<160..216	CDD:462301	24/61 (39%)
		Ion_trans_2	307..382	CDD:462301	29/79 (37%)