Protein Alignment galene and twk-8

DIOPT Version :10

• Sequence 1: NP_612084.1
• Gene: galene / 38133
• FlyBaseID: FBgn0035192
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001023596.1
• Gene: twk-8 / 177727
• WormBaseID: WBGene00006663
• Length: 769
• Species: Caenorhabditis elegans
• Alignment Length: 690
• Identity: 102/690 - (14%)
• Similarity: 183/690 - (26%)
• Gaps: 393/690 - (56%)

  Fly    39 VSHVLLVLLVVSYCVGGAYLFQHLE--------RPHELEVKRDIQNLRVNLTENIWLLSDDAVVL 95
            :.::..::.::.|.:.||.:|..||        ...:.:.||:.:.|.:.:.|    |..|....
 Worm    87 IKYLFPLIFIMFYMLIGAIIFYLLESGTAEDAANEEDYKYKRERRLLLLRMEE----LVQDTASR 147

  Fly    96 RESDWMANVSKHLANFEKQILTAIKADGWDGDEDLRKSQWTFAGSLFYSIIVITTIGYGHISPRT 160
            |.:.....:.:.:.|:|:::..|:|          .:|||||..:::::..:.||||||.|:..|
 Worm   148 RRAYRKKALEEAIDNYEQKLDFAVK----------NESQWTFMSAMYFAGTLFTTIGYGDIACIT 202

  Fly   161 DWGKVTTIFYAIVGIPLMLICLSNIGDVMATSFRFLYWRICCYVCTRTAKRPRNARSRQRSMRSQ 225
            ..|::.|:.|:.||||.|||.|:::|       :|||
 Worm   203 SAGRIATVIYSCVGIPFMLITLNDLG-------KFLY---------------------------- 232

  Fly   226 RHARSQPPPSFRRSMKMTQRSGNDSGLGPSMGHAYSDPDLRTMGRGYDD--------REFGHRSS 282
                                 .|.:|                ..:|::|        |....|.:
 Worm   233 ---------------------NNING----------------CVKGFEDFTTYLGAFRLCNRRGN 260

  Fly   283 GGGRNRRQQQQQHLHHDPRQRHTIYGDGYETQTLNRSNRYSSRQRQRDRMRDRHTVERERYSRSH 347
            |.                      :..|.|..|
 Worm   261 GN----------------------FQKGDELVT-------------------------------- 271

  Fly   348 LDAGSIEDFGDMQPPAKRAASVRSVRSPHNQESSKASRELHRLHSAPGRSRAKSVDPRHVSSHYE 412
            |:||:.   |....|                       |:..|.|..|..|.:        |.||
 Worm   272 LEAGTT---GTTDAP-----------------------EVSSLASELGSERNE--------SDYE 302

  Fly   413 DVDEDVVRKTPIIPNRYALDDFGGNRRQAAPRSQSMPRSAHQRQRQKDRERERSPQPPPQSSYRQ 477
            |::::                          ..:||||
 Worm   303 DIEDE--------------------------EERSMPR--------------------------- 314

  Fly   478 QHDRRAGSLGRQSSRYGNHLELPDYDAPPPGRDHRRDRRGHSQGRYEDYVEESFDEGSLYGDNNY 542
                                                                             
 Worm   315 ----------------------------------------------------------------- 314

  Fly   543 EDYPPERHHSRSREPKRNRRRERAERLPPSPRIMSPMGFPVQRQIRRRPSYDYDDDDSMYGDEYG 607
                                                                             
 Worm   315 ----------------------------------------------------------------- 314

  Fly   608 DYGDLLPKDRPVPIWLCVFLVVSYILGGAVLFAYWENWSFLDSAYFCFITLTTIGFGDFVPAKGV 672
                       :.:.:.:.:.|.:|...:.||..||:||:..|.||.||:|:|||.||      |
 Worm   315 -----------MSVKVALGITVGWIFFCSALFKLWEDWSYGQSCYFMFISLSTIGLGD------V 362

  Fly   673 KDESEQSIAYCSLYLLFGIALLAMSFNLVQ---EEFIANV 709
            ..:....:..|.::::.|::|::|:.|::|   |:|..|:
 Worm   363 SVQRRDMMVLCFVFVIVGLSLVSMTINVIQVALEDFYVNL 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	115..189	CDD:462301	27/73 (37%)
		Ion_trans_2	626..706	CDD:462301	27/82 (33%)
twk-8	NP_001023596.1	Ion_trans_2	169..233	CDD:462301	30/129 (23%)
		Ion_trans_2	323..397	CDD:462301	26/79 (33%)