DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment galene and Kcnk4

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_006526779.1	Gene:	Kcnk4 / 16528	MGIID:	1298234	Length:	444	Species:	Mus musculus

Alignment Length:	517	Identity:	115/517 - (22%)
Similarity:	175/517 - (33%)	Gaps:	154/517 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RRAQSLPAHMLEP-------AKPQRGRCVAAICFSWKVLTCIVSHVLLVLLVVSYCVGGAYLFQH 61
            ||..:.|..:..|       |.|..||.:.:        |.:::.:.||||   |.|.||.:||.
Mouse    19 RRLTTAPQELPAPSSQAGSGAGPASGRTMRS--------TTLLALLALVLL---YLVSGALVFQA 72

  Fly    62 LERPHELEVKRDIQNLRVNLTENIWLLSDDAVVLRESDWMANVSKHLANFEKQILTAI-----KA 121
            ||:|||.:.::.:.:.|..      .|.|...|.::|         |.:|.|.::.|:     ..
Mouse    73 LEQPHEQQAQKKMDHGRDQ------FLRDHPCVSQKS---------LEDFIKLLVEALGGGANPE 122

  Fly   122 DGWDGDEDLRKSQWTFAGSLFYSIIVITTIGYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIG 186
            ..|....: ..|.|....:.|:|..:|||||||:|...||.|::..||||:|||||..:.|:.:|
Mouse   123 TSWTNSSN-HSSAWNLGSAFFFSGTIITTIGYGNIVLHTDAGRLFCIFYALVGIPLFGMLLAGVG 186

  Fly   187 DVMATSFR---------FLYWRICCYVCTRTAKRPRNARSRQRSMRSQRHARSQPPPSFRRSMKM 242
            |.:.:|.|         ||.|.:                                ||...||:
Mouse   187 DRLGSSLRRGIGHIEAIFLKWHV--------------------------------PPGLVRSL-- 217

  Fly   243 TQRSGNDSG------------LGPSMGHAYSDP------------DLRTMGRGYDDREFGHRSSG 283
                   |.            |.|:...:|.:.            .|.|:|       ||....|
Mouse   218 -------SAVLFLLIGCLLFVLTPTFVFSYMESWSKLEAIYFVIVTLTTVG-------FGDYVPG 268

  Fly   284 GGRNRRQQQQQHLHHDPRQRHTIYGDGYETQTLNRSNRYSSRQRQRDRMRDRHTVERERYSRSHL 348
            .|..:.....|.|    .....::|..|....|.....:.....:|.|........:.......:
Mouse   269 DGTGQNSPAYQPL----VWFWILFGLAYFASVLTTIGNWLRAVSRRTRAEMGGLTAQAASWTGTV 329

  Fly   349 DAGSIEDFGDMQPPAKRAASV--------RSVRSPHNQESSKASRELHRLHSAPGRSRAKSVDPR 405
            .|...:..|...||.::...:        .:|..|..:..|.|..|.....|.|   .|.::|
Mouse   330 TARVTQRTGPSAPPPEKEQPLLPSSLPAPPAVVEPAGRPGSPAPAEKVETPSPP---TASALD-- 389

  Fly   406 HVSSHYEDVDEDVVRKTPIIPNRYALDDFGGNRRQAAPRSQSMPRSAHQRQRQKDRERERSP 467
            :.|.:...:||.              .|....|..|.||:   ||...:....|...|.|.|
Mouse   390 YPSENLAFIDES--------------SDTQSERGCALPRA---PRGRRRPNPSKKPSRPRGP 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	26/54 (48%)
		NESP55	341..586	CDD:115071	27/135 (20%)
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
Kcnk4	XP_006526779.1	Ion_trans_2	<135..189	CDD:369572	26/53 (49%)
		Ion_trans_2	227..305	CDD:369572	15/88 (17%)
		SucB_Actino	<327..>398	CDD:200219	14/75 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9871
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	130	1.000	Inparanoid score	I4619
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.960