DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment galene and kcnq2a

DIOPT Version :9

Sequence 1:	NP_612084.1	Gene:	galene / 38133	FlyBaseID:	FBgn0035192	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001108379.1	Gene:	kcnq2a / 100141342	ZFINID:	ZDB-GENE-080220-37	Length:	349	Species:	Danio rerio

Alignment Length:	173	Identity:	35/173 - (20%)
Similarity:	75/173 - (43%)	Gaps:	15/173 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RGRCVAAICFSWKVLTCIVSHVLL---VLLVVSYCVGGAYLFQHLERPHELEVKRDIQNLRVNLT 82
            |||    :.|:.|.. ||:..::|   |.::.:...|..:....:.....|::   ::.||::..
Zfish   158 RGR----LRFARKPF-CIIDIMVLFASVSVLAAGSQGNVFATSAIRSLRFLQI---LRMLRMDRR 214

  Fly    83 ENIWLLSDDAVVLRESDWMANVSKHLANFEKQILTAIKADGWDGDEDLRKSQWTFAGSLFYSIIV 147
            ...|.|....|.....:.   ::.....|...||.:......:.|::....: |:|.:|::.::.
Zfish   215 GGTWKLLGSVVYAHSKEL---ITAWYIGFLCLILASFLVYSVEKDDNAEMFE-TYADALWWGLVT 275

  Fly   148 ITTIGYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGDVMA 190
            :||||||...|.|..|::....::::|:....:....:|...|
Zfish   276 LTTIGYGDKFPVTWNGRLIAATFSLIGVAFFALPAGILGSGFA 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galene	NP_612084.1	Ion_trans_2	<134..189	CDD:285168	14/54 (26%)
		NESP55	341..586	CDD:115071
		Ion_trans	<621..709	CDD:278921
		Ion_trans_2	626..706	CDD:285168
kcnq2a	NP_001108379.1	Ion_trans	119..325	CDD:278921	35/173 (20%)
kcnq2a	NP_001108379.1	Ion_trans_2	240..315	CDD:285168	17/75 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D774951at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010